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Author: Wu-Min Deng Publisher: Springer Nature ISBN: 3030236293 Category : Medical Languages : en Pages : 251
Book Description
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Author: Wu-Min Deng Publisher: Springer Nature ISBN: 3030236293 Category : Medical Languages : en Pages : 251
Book Description
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Author: Masamitsu Yamaguchi Publisher: Springer ISBN: 9811305293 Category : Medical Languages : en Pages : 314
Book Description
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Author: Farzana Khan Perveen Publisher: BoD – Books on Demand ISBN: 9535138537 Category : Technology & Engineering Languages : en Pages : 270
Book Description
This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Author: John Rozehnal Publisher: ISBN: Category : Languages : en Pages : 42
Book Description
Introduction: The selection of appropriate anticancer drugs in patients is a great challenge in cancer treatment. As medicine seeks to understand the difference between the “average” tumor and a tumor in an individual patient, there is great uncertainty regarding the effect of particular genes and drugs that target them. Transgenic Drosophila melanogaster has been proposed as a rapid and efficient system in which to generate a reliable model of an individual tumor and phenotypic screen for effective drugs. Such screens can potentially lead to the identification of a molecule that modifies a cancer phenotype by acting on a previously undescribed target or by acting simultaneously on more than one target.Methods: 97 Patients were assessed for genomic and clinical data. 12 patients had tumor genetics analyzed and models created that comprised driver mutations. 3 models were attempted in Drosophila and tested against 19 anticancer drugs.Results: 1 of 3 models was technically successful and advanced to drug screening. 5 drugs (gemcitabine, trametinib, crizotinib, doxorubicin, docetaxel) were predicted by the model to be effective against that particular cancer. However, neither of the two drugs used in the corresponding patient were predicted to be successful.Conclusions: While this project was unable to concretely validate the Drosophila modeling approach by accurately predicting treatment outcomes. I was able to develop and advance methods to predict the effects of a gene within a tumor and to develop one complete Drosophila model that responded to anticancer drugs in a dose-dependent manner. Further research is needed to assess the predictive value of these models.
Author: Robert C. Bast, Jr. Publisher: John Wiley & Sons ISBN: 111900084X Category : Medical Languages : en Pages : 2004
Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Stephanie Elizabeth Mohr Publisher: Harvard University Press ISBN: 0674984730 Category : Science Languages : en Pages : 273
Book Description
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.
Author: Stephen J. Simpson Publisher: Princeton University Press ISBN: 0691145652 Category : Medical Languages : en Pages : 260
Book Description
Nutrition has long been considered more the domain of medicine and agriculture than of the biological sciences, yet it touches and shapes all aspects of the natural world. The need for nutrients determines whether wild animals thrive, how populations evolve and decline, and how ecological communities are structured. 'The Nature of Nutrition' addresses nutrition's enormously complex role in biology, both at the level of individual organisms and in their broader ecological interactions.
Author: Publisher: ISBN: Category : Languages : en Pages : 44
Book Description
Chronic inflammation is a fundamental condition underlying many human disease pathologies including diabetes, cancer, and neurodegeneration. Indeed, one of the most commonly-used anti-inflammatory drugs, aspirin, has been shown to be effective in the treatment of many cancers. To understand the mechanistic linkages between inflammation and cancer, we used Drosophila models in which hyperactive immune signaling causes overproliferation of the hematopoietic system leading to the production of inflammatory blood tumors. In mutant animals, hematopoietic cells divide uncontrollably and exhibit pre-mature differentiation giving rise to large sticky cells. Some mutant cells infiltrate and adhere to cells of the fat body. The fat body is a large organ in fly larvae and akin to the mammalian liver. In wild type larvae, hematopoietic cells exhibit limited rounds of division, and circulating cells in the hemolymph do not stick to fat body. Our hypothesis was that if the biochemistry and genetic circuitry underlying inflammation biology in flies is conserved, then aspirin administration should have the same therapeutic effects on tumor growth and infiltration in fly mutants as it does in humans. Here we show that sublethal levels of systemically-administered aspirin improve viability of mutants and reduce the size and abundance of blood tumors. The accompanying infiltration of blood cells on larval fat body cells of mutants is also reduced. These results support our hypothesis and suggest that the mechanisms underlying aspirin’s effects in flies may be similar with those in mammals. These studies underscore the value of the Drosophila model system and present exciting possibilities for uncovering shared mechanisms.
Author: Wu-Min Deng
Author: Wu-Min Deng
Author: Masamitsu Yamaguchi
Author: Takeshi Shimizu
Author: Farzana Khan Perveen
Author: John Rozehnal
Author: Robert C. Bast, Jr.
Author: Stephanie Elizabeth Mohr
Author: Bruce Alberts
Author: Stephen J. Simpson
Author: