Author: Eugen Scholz Publisher: Springer Science & Business Media ISBN: 3642699898 Category : Science Languages : en Pages : 142
Book Description
The Karl Fischer titration is used in many different ways following its publication in 1935 and further applications are continually being explored. At the present time we are experiencing another phase of expansion, as shown by the development of new titration equipment and new reagents. KF equipment increasingly incorporates microprocessors which enable the course of a titration to be programmed thus sim plifying the titration. Coulometric titrators allow water determinations in the micro gram-range: the KF titration has become a micro-method. The new pyridine-free re agents make its application significantly more pleasant and open up further possibili ties on account of their accuracy. To make the approach to Karl Fischer titrations easier, we have summarized the present knowledge in this monograph and we have complemented it with our own studies and practical experience. As this book should remain "readable", we have tried to keep the fundamentals to a minimum. Historical developments are only mentioned if they seem to be necessary for understanding the KF reaction. The ap plications are described more fully. Specific details which may interest a particular reader can be found in the original publications cited. The referenced literature is in chronological order as the year of publication may also prove informative. Thus, [6902] for example denotes 69 for 1969 being the year of publication and 02 is a non-recurring progressive number. The referenced litera ture includes summaries which we hope will be of help to find the "right" publica tion easily.
Author: Christopher M. Riley Publisher: Elsevier ISBN: 0080530354 Category : Science Languages : en Pages : 363
Book Description
The need to validate an analytical or bioanalytical method is encountered by analysts in the pharmaceutical industry on an almost daily basis, because adequately validated methods are a necessity for approvable regulatory filings. What constitutes a validated method, however, is subject to analyst interpretation because there is no universally accepted industry practice for assay validation. This book is intended to serve as a guide to the analyst in terms of the issues and parameters that must be considered in the development and validation of analytical methods. In addition to the critical issues surrounding method validation, this book also deals with other related factors such as method development, data acquisition, automation, cleaning validation and regulatory considerations. The book is divided into three parts. Part One, comprising two chapters, looks at some of the basic concepts of method validation. Chapter 1 discusses the general concept of validation and its role in the process of transferring methods from laboratory to laboratory. Chapter 2 looks at some of the critical parameters included in a validation program and the various statistical treatments given to these parameters.Part Two (Chapters 3, 4 and 5) of the book focuses on the regulatory perspective of analytical validation. Chapter 3 discusses in some detail how validation is treated by various regulatory agencies around the world, including the United States, Canada, the European Community, Australia and Japan. This chapter also discusses the International Conference on Harmonization (ICH) treatment of assay validation. Chapters 4 and 5 cover the issues and various perspectives of the recent United States vs. Barr Laboratories Inc. case involving the retesting of samples. Part Three (Chapters 6 - 12) covers the development and validation of various analytical components of the pharmaceutical product development process. This part of the book contains specific chapters dedicated to bulk drug substances and finished products, dissolution studies, robotics and automated workstations, biotechnology products, biological samples, analytical methods for cleaning procedures and computer systems and computer-aided validation. Each chapter goes into some detail describing the critical development and related validation considerations for each topic.This book is not intended to be a practical description of the analytical validation process, but more of a guide to the critical parameters and considerations that must be attended to in a pharmaceutical development program. Despite the existence of numerous guidelines including the recent attempts by the ICH to be implemented in 1998, the practical part of assay validation will always remain, to a certain extent, a matter of the personal preference of the analyst or company. Nevertheless, this book brings together the perspectives of several experts having extensive experience in different capacities in the pharmaceutical industry in an attempt to bring some consistency to analytical method development and validation.
Author: Klaus Grasshoff Publisher: John Wiley & Sons ISBN: 3527613994 Category : Science Languages : de Pages : 632
Book Description
Since the book first appeared in 1976, Methods of Seawater Analysis has found widespread acceptance as a reliable and detailed source of information. Its second extended and revised edition published in 1983 reflected the rapid pace of instrumental and methodological evolution in the preceding years. The development has lost nothing of its momentum, and many methods and procedures still suffering their teething troubles then have now matured into dependable tools for the analyst. This is especially evident for trace and ultra-trace analyses of organic and inorganic seawater constituents which have diversified considerably and now require more space for their description than before. Methods to determine volatile halocarbons, dimethyl sulphide, photosynthetic pigments and natural radioactive tracers have been added as well as applications of X-ray fluorescence spectroscopy and various electrochemical methods for trace metal analysis. Another method not previously described deals with the determination of the partial pressure of carbon dioxide as part of standardised procedures to describe the marine CO2 system.
Author: Publisher: Elsevier ISBN: 0323958222 Category : Technology & Engineering Languages : en Pages : 5674
Book Description
The Encyclopedia of Electrochemical Power Sources, Second Edition, is a comprehensive seven-volume set that serves as a vital interdisciplinary reference for those working with batteries, fuel cells, electrolyzers, supercapacitors, and photo-electrochemical cells. With an increased focus on the environmental and economic impacts of electrochemical power sources, this work not only consolidates extensive coverage of the field but also serves as a gateway to the latest literature for professionals and students alike. The field of electrochemical power sources has experienced significant growth and development since the first edition was published in 2009. This is reflected in the exponential growth of the battery market, the improvement of many conventional systems, and the introduction of new systems and technologies. This completely revised second edition captures these advancements, providing updates on all scientific, technical, and economic developments over the past decade. Thematically arranged, this edition delves into crucial areas such as batteries, fuel cells, electrolyzers, supercapacitors, and photo-electrochemical cells. It explores challenges and advancements in electrode and electrolyte materials, structural design, optimization, application of novel materials, and performance analysis. This comprehensive resource, with its focus on the future of electrochemical power sources, is an essential tool for navigating this rapidly evolving field. - Covers the main types of power sources, including their operating principles, systems, materials, and applications - Serves as a primary source of information for electrochemists, materials scientists, energy technologists, and engineers - Incorporates 365 articles, with timely coverage of environmental and sustainability aspects - Arranged thematically to facilitate easy navigation of topics and easy exploration of the field across its key branches - Follows a consistent structure and features elements such as key objective boxes, summaries, figures, references, and cross-references etc., to help students, faculty, and professionals alike
Author: Daniel C. Harris Publisher: Macmillan Higher Education ISBN: 131904803X Category : Science Languages : en Pages : 998
Book Description
The gold standard in analytical chemistry, Dan Harris’ Quantitative Chemical Analysis provides a sound physical understanding of the principles of analytical chemistry and their applications in the disciplines
Author: Erno Pungor Publisher: CRC Press ISBN: 1000142442 Category : Science Languages : en Pages : 404
Book Description
A Practical Guide to Instrumental Analysis covers basic methods of instrumental analysis, including electroanalytical techniques, optical techniques, atomic spectroscopy, X-ray diffraction, thermoanalytical techniques, separation techniques, and flow analytical techniques. Each chapter provides a brief theoretical introduction followed by basic and special application experiments. This book is ideal for readers who need a knowledge of special techniques in order to use instrumental methods to conduct their own analytical tasks.
Author: S. Suzanne Nielsen Publisher: Springer Science & Business Media ISBN: 1441914633 Category : Technology & Engineering Languages : en Pages : 150
Book Description
This second edition laboratory manual was written to accompany Food Analysis, Fourth Edition, ISBN 978-1-4419-1477-4, by the same author. The 21 laboratory exercises in the manual cover 20 of the 32 chapters in the textbook. Many of the laboratory exercises have multiple sections to cover several methods of analysis for a particular food component of characteristic. Most of the laboratory exercises include the following: introduction, reading assignment, objective, principle of method, chemicals, reagents, precautions and waste disposal, supplies, equipment, procedure, data and calculations, questions, and references. This laboratory manual is ideal for the laboratory portion of undergraduate courses in food analysis.
Author: Eugen Scholz
Author: Christopher M. Riley
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Author: Klaus Grasshoff
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Author: Daniel C. Harris
Author: Erno Pungor
Author: S. Suzanne Nielsen
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