Author: Vishal Anil VermaPublisher:
ISBN:
Category :
Languages : en
Pages : 374
Book Description
The Design, Synthesis, and Evaluation of Novel Bryostatin Analogs
The Design, Synthesis, and Biological Evaluation of Structurally Simplified Bryostatin and Laulimalide Analogues
Author: Michael Kenneth HilinskiPublisher:
ISBN:
Category :
Languages : en
Pages : 682
Book Description
The Design, Synthesis and Biological Evaluation of the First Totally Synthetic Bryostatin Analogues
Author: Blaise LippaOutstanding Marine Molecules
Author: Stephane La BarrePublisher: John Wiley & Sons
ISBN: 3527681531
Category : Science
Languages : en
Pages : 1009
Book Description
Using a number of outstanding examples, this text introduces readers to the immense variety of marine natural compounds, the methodologies to characterize them and the approaches to explore their industrial potential. Care is also taken to discuss the function and ecological context of the compounds. Carefully produced and easy to read, this book serves students and professionals wishing to familiarize themselves with the field, and is ideally suited as a course book for both industry to academia.
Natural Products in Medicinal Chemistry
Author: Stephen HanessianPublisher: John Wiley & Sons
ISBN: 3527676562
Category : Medical
Languages : en
Pages : 658
Book Description
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
I. Design, Synthesis, and Biological Evaluation of New Analogs of Bryostatin ; II. Investigations Into the Mode of Action of Apoptolidin A
Author: Jeremy L. BaryzaThe Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters
Author: Kanaka PattabiramanAnticancer Agents from Natural Products, Second Edition
Author: Gordon M. CraggPublisher: CRC Press
ISBN: 1439813825
Category : Science
Languages : en
Pages : 786
Book Description
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Practical Medicinal Chemistry with Macrocycles
Author: Eric MarsaultPublisher: John Wiley & Sons
ISBN: 1119092566
Category : Science
Languages : en
Pages : 617
Book Description
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Studies in Natural Products Chemistry
Author: Atta-ur RahmanPublisher: Elsevier
ISBN: 0444637567
Category : Science
Languages : en
Pages : 436
Book Description
Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores