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The Design and Analysis of Sequential Clinical Trials

The Design and Analysis of Sequential Clinical Trials PDF Author: John Whitehead
Publisher: John Wiley & Sons
ISBN: 9780471975502
Category : Science
Languages : en
Pages : 342

Book Description
This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
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