The Cox-2 Connection PDF Download

Author: James B. LaValle
Publisher: Inner Traditions / Bear & Co
ISBN: 9780892819843
Category : Family & Relationships
Languages : en
Pages : 178

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Book Description
In this innovative text, James LaValle clearly explains what can cause joint and muscle inflammation, then sets forward mutliple treatments, with step-by-step instructions on how to use these treatments most effectively. Futhermore, he writes about exciting new studies that indicate the possible effectiveness of Cox-2 inhibitors in treating diseases such as cancer and Alzheimer's.

Author: Jamie A. Goode
Publisher: John Wiley & Sons
ISBN: 9780471499596
Category : Science
Languages : en
Pages : 322

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Book Description
Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.

Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 1139491989
Category : Medical
Languages : en
Pages : 551

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Book Description
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.

Author: Jack Cox
Publisher: John Wiley & Sons
ISBN: 111841716X
Category : Computers
Languages : en
Pages : 362

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Book Description
Learn to develop iPhone and iPad applications for networked enterprise environments The iPhone and iPad have made a powerful impact on the business world. Developers creating iOS apps for the enterprise face unique challenges involving networking, system integration, security, and device management. This Wrox guide provides everything you need to know to write iOS apps that integrate with enterprise network resources, providing options for networking iOS devices to enterprise systems and to each other. Offers a complete compendium of methods and techniques for networked communication between iOS applications and other platforms and devices Includes instruction on incorporating synchronous and asynchronous HTTP requests, security, communication issues, and more Covers payload handling, network security, GameKit and Bonjour communications, and low-level network communications Professional iOS Network Programming focuses on the networking aspects of iOS and its relationship to remote data sources, offering a truly unique approach.

Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 850

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Book Description
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author: Christopher Cox
Publisher: John Wiley & Sons
ISBN: 1119602661
Category : Technology & Engineering
Languages : en
Pages : 452

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Book Description
A comprehensive and approachable introduction to 5G Written by a noted expert on the subject, An Introduction to 5G: The New Radio, 5G Network and Beyond offers an introductory system-level guide to 5G. The material covered includes: The use cases and requirements of the 5G system The architecture of the next generation radio access network and the 5G core The principles of radio transmission, millimetre waves and MIMO antennas The architecture and detailed design of the 5G new radio The implementation of HTTP/2 on the service-based interfaces of the 5G core The signalling procedures that govern the end-to-end-operation of the system The new features that are introduced in Releases 16 and 17 An Introduction to 5G is written for engineering professionals in mobile telecommunications, for those in non-technical roles such as management, marketing and intellectual property, and for students. It requires no more than a basic understanding of mobile communications, and includes detailed references to the underlying 3GPP specifications for 5G. The book's approach provides a comprehensive, end-to-end overview of the 5G standard, which enables readers to move on with confidence to the more specialized texts and to the specifications themselves.

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309459575
Category : Medical
Languages : en
Pages : 483

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Book Description
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728

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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author: Amy Cox-Petersen
Publisher: SAGE Publications
ISBN: 1506341772
Category : Education
Languages : en
Pages : 353

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Book Description
Supporting teachers in building partnerships with families and the broader community This comprehensive text helps prepare pre-service and in-service teachers to build and sustain family, school, and community partnerships that are vital to student success. Focusing on grades preK–8, and with a particular emphasis on diverse families and learners, this book helps teachers to overcome barriers, create action plans, and sustain partnerships over time. Key Features Chapters provide a contemporary, culturally relevant approach that guides teachers to devise strategies that celebrate cultural, linguistic, and academic diversity. Case studies present multiple perspectives from teachers, students, and community members. Readers are asked to reflect upon the cases, analyze real-life situations, and apply chapter content to each case. "Notes from the Classroom" include personal observations and strategies from teachers that enhance the reader′s experience. "How To" sections show how to develop an action plan or seek outside funding. Planning sheets are included to provide the sequence of specific steps. Student Study Site Free resources will help you prepare for class and exams! Open-access study materials include chapter-specific interactive self-quizzes, vocabulary e-flashcards, recommended Web sites, and "Learning From SAGE Journal Articles." Visit the Student Study Site at www.sagepub.com/coxpetersen. Instructor Teaching Site Instructors have access to the following password-protected resources: a test bank with sortable questions, PowerPoint slides for each chapter, recommended Web sites, ample syllabi, and teaching tips.

Author: Gary W. Cox
Publisher: Cambridge University Press
ISBN: 9780521585279
Category : Political Science
Languages : en
Pages : 362

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Book Description
Popular elections are at the heart of representative democracy. Thus, understanding the laws and practices that govern such elections is essential to understanding modern democracy. In this book, Cox views electoral laws as posing a variety of coordination problems that political forces must solve. Coordination problems - and with them the necessity of negotiating withdrawals, strategic voting, and other species of strategic coordination - arise in all electoral systems. This book employs a unified game-theoretic model to study strategic coordination worldwide and that relies primarily on constituency-level rather than national aggregate data in testing theoretical propositions about the effects of electoral laws. This book also considers not just what happens when political forces succeed in solving the coordination problems inherent in the electoral system they face but also what happens when they fail.