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Author: Firas H. Kobeissy Publisher: CRC Press ISBN: 1466565993 Category : Medical Languages : en Pages : 718
Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: C. Marescaux Publisher: Springer Science & Business Media ISBN: 3709192064 Category : Medical Languages : en Pages : 294
Book Description
Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.
Author: Edward G. Jones Publisher: Springer Science & Business Media ISBN: 1475796161 Category : Medical Languages : en Pages : 455
Book Description
The barrel area is a unique specialization of the cerebral cortex, shared by many species of rodents and some marsupials, in which the somatotopic map of the body surface receives direct morphological expression. Here, the homogeneous sheet of layer IV granule cells seen in most mammals is fractured into large archipelagos, each representing one of the larger subdivisions of the contra lateral half-body. Within these larger domains are smaller aggregates of granule cells that contain the concentrated terminations of thalamocortical fibers bear ing messages emanating from constellations of receptors located in finer subdi visions of a body part. These smaller aggregates are particularly well-defined in the representation of the face, where they form a one-to-one representation of the sinus hairs or vibrissae and where they have been given the name barrels. The first inklings of the unique structure of the parietal cortex of rodents came in the study of Droogleever-Fortuyn (1914), who remarked on the pres ence in it of clouds of granule cells 0. 5-1 mm in diameter, which he thought were in some way associated with concentrations of nerve fibers. Little attention, however, was paid to his observations. Lorente de N 6 (1922) later observed dense focal concentrations of afferent fiber ramifications in Golgi preparations of the mouse cortex, calling them glomeruli, and these can now be seen as the structures that form the hearts of the barrels and around which the granule cells concentrate.
Author: György Buzsáki Publisher: Springer ISBN: 3319288024 Category : Medical Languages : en Pages : 181
Book Description
This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.
Author: George Paxinos Publisher: Academic Press ISBN: 9780125476409 Category : Science Languages : en Pages : 0
Book Description
The Mouse Brain in Stereotaxic Coordinates, Second Edition has been the acknowledged reference in this field since the publication of the first edition, and is now available in a Compact Edition. This will provide a more affordable option for students, as well as researchers needing an additional lab atlas. This version includes the coronal diagrams delineating the entire brain as well as the introductory text from the Deluxe edition. It is an essential reference for anyone studying the mouse brain or related species.
Author: Jerry J. Buccafusco Publisher: CRC Press ISBN: 1420041819 Category : Medical Languages : en Pages : 341
Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic