The Brain of the Common Marmoset (Callithrix jacchus) PDF Download

Author: H. Stephan
Publisher: Springer Science & Business Media
ISBN: 3642674917
Category : Science
Languages : en
Pages : 99

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Author: Robert P. Marini
Publisher: Academic Press
ISBN: 012811830X
Category : Science
Languages : en
Pages : 572

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Book Description
The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. - Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications - Includes contributions from renowned and international authors and editors - Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Author: Joerg Bluemel
Publisher: Academic Press
ISBN: 012417146X
Category : Medical
Languages : en
Pages : 716

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Book Description
The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Author: Craig D. Hardman
Publisher: CRC Press
ISBN: 1439837783
Category : Medical
Languages : en
Pages : 522

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Book Description
Developing better therapies for neurological conditions such as Parkinson’s and Alzheimer’s diseases remains an enduring problem for 21st century medicine. The testing of novel therapies will continue to require a robust experimental animal model. The marmoset is an ideal animal model for modern neurological research because of the species’ convenient body size, ease of handling, and the fundamental similarity of its neuroanatomy to the human brain. The Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset (Callithrix jacchus) is the most detailed atlas of the marmoset brain available. An essential tool for researchers developing more effective therapies for disabling and debilitating neurological disorders, the book contains: Fully delineated, high-quality (400x magnification) images of Nissl-stained, acetylcholinesterase histochemically-stained and parvalbumin, calbindin and neurofilament immunohistochemically-stained coronal and sagittal sections, as well as structural magnetic resonance images (MRI) for direct comparisons Line diagrams with delineations of all cortical and subcortical structures, with grid overlays so the precise position of each structure can be located stereotaxically relative to the interaural line and infraorbital margin Quantitative data regarding volume and cell number of many of the structures delineated in the atlas, regularly updated on an accompanying website Standard nomenclature widely used in the Paxinos group of atlases, allowing users to compare and contrast homologous nuclei in different species using the major available atlases The book combines modern imaging (MRI) with an accurate stereotaxic and chemoarchitectonic section atlas, making the fullest use of available technologies. The companion DVD includes all the images in full color. Designed by publishing neuroanatomists, this book/DVD will be a cornerstone in marmoset brain research for years to come.

Author: George Paxinos
Publisher: Academic Press
ISBN: 9780124158184
Category : Science
Languages : en
Pages : 0

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Book Description
The Marmoset Brain in Stereotaxic Coordinates is the most comprehensive atlas of the brain of this animal available. The atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most-cited book in neuroscience. It represents a collaboration between world leaders in neuroanatomy of the primate cortex and subcortex. It will be an indispensible tool for neuroanatomists, behavioral neuroscientists, and molecular biologists trying to understand the primate brain. ENDORSED BY SOCIETY FOR BRAIN MAPPING AND THERAPEUTICS (SBMT) - SBMT is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping, engineering, stem cell, nanotechnology, imaging and medical device to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. This society promotes the public welfare and improves patient care through the translation of new technologies/therapies into life saving diagnostic and therapeutic procedures. The Society is focused in breaking boundaries of science, technology, medicine, art and healthcare policy. For more information about how to become a member or participate in SBMT programs please visit: www.WorldBrainMapping.org

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309488516
Category : Science
Languages : en
Pages : 123

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Book Description
The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Author: Craig D. Hardman
Publisher: CRC Press
ISBN: 1439837791
Category : Medical
Languages : en
Pages : 515

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Book Description
Developing better therapies for neurological conditions such as Parkinson's and Alzheimer's diseases remains an enduring problem for 21st century medicine. The testing of novel therapies will continue to require a robust experimental animal model. The marmoset is an ideal animal model for modern neurological research because of the species' conveni

Author: Atsushi Iriki
Publisher: Springer
ISBN: 4431566120
Category : Medical
Languages : en
Pages : 396

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Book Description
This book provides accurate, comprehensive, and convenient reference for usages of the “freely rotatable three dimensional combined Nissl-stained and MRI digital data of the marmoset brain”. The key features of the original 3D digital data and of this atlas are: 1. The original digital datasets are freely rotatable in three dimensions, thus expected to be useful for any disciplines and anatomical interest, using any coordinate system, 2. Combined Nissl stained and MRI images are obtained from the same marmoset, to allow cross-modality matched references for multiple usages, 3. 86 Horizontal Series of Images with Neurosurgical Plane (based on the actual data), with more accuracy and resolution (Chapter 2) than the web-based digital images, 4. 32 Coronal Series of Images with Neurosurgical Plane (reproduced from the brain model) (Chapter 3), 5. 10 Parasagittal Series of Images with Neurosurgical Plane (reproduced from the brain model) (Chapter 4), 6. 3 Omnidirectionally Sliceable Planes (reproduced from the brain model) (Chapter 5), 7. In order to provide higher resolution structures to match systematic accuracy for supplementation of the digital data on the website, additional information are included. They are: 1) Nomenclature, 2) List of Brain Structures in Hierarchical Order, 3) Index of Abbreviations, together with 143 useful Bibliographic References list as of 2016, 8. Horsley-Clarke’s stereotaxic coordinates were adopted in the present atlas.

Author: Rudolf Jaenisch
Publisher:
ISBN: 9781013268564
Category : Medical
Languages : en
Pages : 128

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Book Description
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author: Charles Watson
Publisher: Academic Press
ISBN: 0080921388
Category : Medical
Languages : en
Pages : 408

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Book Description
Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN). - The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements - The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals - The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN) - All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply