The Biology of the Mycobacteria: Physiology, identification, and classification PDF Download

Author: Colin Ratledge
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 568

View

Book Description

Author: C. Ratledge
Publisher: John Wiley & Sons
ISBN: 1444311441
Category : Science
Languages : en
Pages : 416

View

Book Description
Tuberculosis continues to kills more people than any other single infective agent. The resurgence of the disease in many countries has produced a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis. This book provides an up-to-date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature, such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but also will find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis. Comprehensively covers recent advances in the molecular biology of the mycobacteria. First book to be published on this subject since the publishing of the complete genome for the tubercle bacillus (M. tuberculosis). Coincides with a worldwide resurgence of tuberculosis.

Author: Graham F. Hatfull
Publisher: John Wiley & Sons
ISBN: 1555818846
Category : Science
Languages : en
Pages : 832

View

Book Description
A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Author: Colin Ratledge
Publisher:
ISBN:
Category : Mycobacteria
Languages : en
Pages : 648

View

Book Description

Author: Pattisapu R.J. Gangadharam
Publisher: Springer Science & Business Media
ISBN: 9780412054518
Category : Science
Languages : en
Pages : 420

View

Book Description
Mycobacteria is divided into two volumes. The first volume deals with the basic biology of mycobacteria. With its emphasis on the state of the art outlook, this volume includes taxonomy and molecular biology of mycobacteria, modern approaches for detection of mycobacteria, and immunology and immunization against tuberculosis. The second volume covers drug trestments for mycobacteria anad tuberculosis. It outlines trends of discovery and development of chemotherapy, starting from the mid-50's to present day uses of chemotherapy in treating AIDS, drug-resistant tuberculosis, and other non-tuberculosis mycobacterial diseases.

Author: Zeeshan Fatima
Publisher: Academic Press
ISBN: 0323919448
Category : Science
Languages : en
Pages : 316

View

Book Description
Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome. Covers major biochemical aspects of mycobacterial lipids, nomenclature, structure and classification, and metabolic pathways Focuses on recent trends and state-of-the-art technology, used in mycobacterial lipids study Brings together the functional aspects of mycobacterial lipidome, involvement of lipids in cellular network and signaling, its involvement in virulence and resistance, and host factor manipulations Highlights the discovery of lipid biomarkers, for diagnostic and therapeutic interventions, using mycobacterial lipidomic studies Presents lipids at the interface of various other biomolecules with integrative omics aspects

Author: Mamadou Daffé
Publisher:
ISBN: 9781555814687
Category : Bacterial cell walls
Languages : en
Pages : 0

View

Book Description
Explains the unique characteristics that cause this large group of bacteria responsible for tuberculosis and leprosy to function differently; serves as a valuable reference for those working in the areas of biochemistry, genetics, genomics, and immunology.

Author: Seyed Ehtesham Hasnain
Publisher: Springer Nature
ISBN: 9813294132
Category : Medical
Languages : en
Pages : 524

View

Book Description
This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.

Author: Colin Ratledge
Publisher:
ISBN:
Category : Mycobacterial diseases
Languages : en
Pages : 621

View

Book Description

Author: Tanya Parish
Publisher: Taylor & Francis
ISBN: 9781904933144
Category : Medical
Languages : en
Pages : 351

View

Book Description
Millions of people die each year from tuberculosis and millions more are infected. The emergence of drug-resistant forms of Mycobacteriumcombined with the paucity of new drugs makes the study of the molecular biology of this organism especially urgent. In this book expert researchers critically review the current and most recent advances in this vitally important subject. The focus is on the topical and most relevant aspects of mycobacterial molecular biology and the book aims to give readers an insight into the current understanding of the subject and the future direction of research. Chapters include sections on future trends, web resources and useful reference sections. Among the topics covered are DNA replication, cell division, regulatory systems, protein export, drug resistance, vaccine technology, and much, much more. Essential reading for scientists and researchers working on mycobacteria and a recommended text for all microbiology laboratories.