The Biology of Corneal Grafts and the Healing Processes of Corneal Wounds PDF Download

Author: Peter Vere Rycroft
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Kyoto Cornea Club. Meeting 1997
Publisher: Kugler Publications
ISBN: 9789062991693
Category : Medical
Languages : en
Pages : 152

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Author: Roger W. Beuerman
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 264

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Author: William Marshall Covode
Publisher:
ISBN:
Category :
Languages : en
Pages : 72

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Author: Jonathan H. Lass
Publisher: Springer Science & Business Media
ISBN: 146155389X
Category : Medical
Languages : en
Pages : 605

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Book Description
These Proceedings of the Fourth International Congress on the Cornea continue a tradition of summarizing the state-of-the art basic and clinical research in cornea and ex ternal diseases since the first Congress was held in 1964. Reflecting the emerging impor tance of refractive surgery, two of the twelve sessions of the Congress were devoted to refractive surgery; this is reflected in an emphasis in these Proceedings. In addition, an en tire session was devoted to the molecular and cellular biology of the cornea with impor tant new information on the role of growth factors and cytokine modulation of corneal wound healing. Within these Proceedings an international group of expert researchers and practitioners provide the latest insights into the tear film and ocular surface, corneal trans plantation and eyebanking, the corneal stroma and endothelium, contact lenses, microbial and nonmicrobial keratitis, keratoconus, and world corneal health. Notable subjects covered include the latest understanding of the barrier function of the ocular surface epithelium, corneal hydration control, the molecular mechanisms con trolling gene expression in corneal wound healing, stromal~pithelial interactions in the cornea, the immunology of blepharitis, the effect of contact lenses on the conjunctiva, morphologic and functional evaluation of the human corneal endothelium, long-term fol low-up of penetrating keratoplasty in keratoconus, the Tampa trephine penetrating kerato plasty, and the refractive results of the Nidek EC-5000 excimer laser.

Author:
Publisher:
ISBN: 9789176013854
Category :
Languages : en
Pages : 56

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Author: James Charles Ramier
Publisher:
ISBN:
Category : Biomechanics
Languages : en
Pages : 160

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"The re-establishment of tissue continuity, function, and mechanical proper ties after a through-and-through incision is an important issue in corneal surgery and trauma. Variations in healing can affect vision and patient activity during the recovery period, which may last up to five years. Growth factors introduced into the open wound have the potential to speed up the wound-healing process. The current investigation is concerned with quantitatively characterizing the mechanical properties of corneal tissue and evaluating the effects of epidermal growth factor (EGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF) on accelerating the wound-healing process as compared to a control group treated with phosphate-buffered saline (PBS). A 30 day topical application period was employed to assess the influence of EGF, IGF, and PDGF versus PBS treated corneas following through-and-through incisions. Corneal test specimens were harvested at 3, 10, and 30 days postoperatively and subjected to uniaxial tension loading (perpendicular to the wound) with load and displacement values recorded. Gross strength properties of fracture toughness, peak tangent modulus, and peak stress were calculated and the stiffness characteristics of the test specimens were obtained through curve fitting of the stress - stretch ratio profile. Comparison of strength properties indicated that IGF application enhanced peak stress, tangent modulus, and fracture toughness at 3 and 10 days while EGF application produced dominant responses at 30 days. Stiffness characterization revealed enhanced stiffness with EGF at 3 and 30 days, while PDGF treatment showed dominant stiffness characteristics at 10 days. The results suggest that select growth factors may preferentially augment the time course of corneal wound healing."--Abstract.

Author: Francis W. Price
Publisher: SLACK Incorporated
ISBN: 9781556428814
Category : Cornea
Languages : en
Pages : 228

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"DSEK: What You Need to Know About Endothelial Keratoplasty provides a comprehensive background of EK, where it is today, and where it is headed in the future. Francis W. Price, MD. who was the first to complete DSEK in the United States, along with Marianne Price, PhD, have designed this text to offer a special emphasis on how to perform surgeries along with preventing and managing complications. In addition, a diverse group of contributing authors provides a wide array of insights and tips for better patient outcomes."--BOOK JACKET.

Author: Jang-Hyun Chung
Publisher:
ISBN:
Category : Alkalies
Languages : en
Pages : 44

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Author: Mohammed Ziaei
Publisher:
ISBN:
Category :
Languages : en
Pages : 328

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Corneal disease leads to a significant burden of blindness worldwide and corneal transplantation remains the primary method of visual rehabilitation in this context. Corneal transplantation is the most commonly performed transplantation procedure in New Zealand with approximately 300 cases completed annually. The aim of this research thesis was to provide an overview of conventional corneal transplantation with its associated limitations and provide a review of emerging options which aim to replace corneal transplantation (wound healing modulation & stem cell therapy) and procedures which aim to delay or eliminate the need for a corneal transplant (cornea crosslinking or CXL). Specifically, data analyses were performed to measure the efficacy of various cornea crosslinking protocols in patients with keratoconus and to assess the properties of the corneal epithelium on the tomographic, refractive and wavefront properties of the keratoconic cornea. A literature review of transplantation rejection pharmacotherapy, umbilical stem cell treatment, wound healing modulation and CXL was performed in the context of corneal disease. One hundred and eighty patients with progressive keratoconus undergoing various corneal crosslinking procedures at the University of Auckland were recruited... The results of the inter-related investigations that form this thesis provide new insights into corneal wound healing modulation & stem cell therapy, provide data on the safety and efficacy of novel CXL protocols and provide further evidence on corneal epithelial remodelling and its role on regularising the anterior corneal surface in keratoconus.