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Author: Guy R. Newell Publisher: Springer Science & Business Media ISBN: 1461534682 Category : Medical Languages : en Pages : 169
Book Description
The papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, "The Biology and Prevention of Aerodigestive Tract Cancers," sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcinogenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phenomena described as "field cancerization. " This process contributes to the development of both synchronous and metachronous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcinogen esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagnosed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.
Author: Guy R. Newell Publisher: Springer Science & Business Media ISBN: 1461534682 Category : Medical Languages : en Pages : 169
Book Description
The papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, "The Biology and Prevention of Aerodigestive Tract Cancers," sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcinogenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phenomena described as "field cancerization. " This process contributes to the development of both synchronous and metachronous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcinogen esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagnosed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.
Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Peter Thomson Publisher: Cambridge Scholars Publishing ISBN: 1527523195 Category : Medical Languages : en Pages : 291
Book Description
This is a concise, informed and practical manual detailing the cause, prevention and interventional treatment of oral cancer – the deadliest of oral diseases. In the 21st century, oral cancer remains a lethal and deforming disease exhibiting rising incidence of epidemic proportions, particularly in younger patients, and is of global significance with over 300,000 new cases presenting each year. Despite advances in diagnosis and management, half of all patients die within five years. Even following successful initial treatment, long-term prognosis is compromised by the presentation of advanced tumours and development of widespread, multi-focal disease throughout the mouth and upper aero-digestive tract. The transformation of normal mouth lining into ‘potentially malignant’ and subsequently malignant tissue is a complex, multistep and multifactorial process in which accumulated genetic alterations, often instigated by overuse of tobacco and alcohol, disrupt the normal functioning of oral epithelial cells. Unfortunately, there is considerable public ignorance regarding oral cancer, and it is imperative for disease prevention to raise awareness of the causes and symptoms of the disease, especially in those populations most ‘at-risk’ of cancer. This book provides pragmatic strategies to improve both prevention and treatment intervention. Spanning nearly 40 years of clinical investigation, it reviews the biological basis of oral cancer, outlines primary, secondary and tertiary preventive strategies and describe a pragmatic treatment intervention protocol that specifically utilizes the ‘potentially malignant window’ to identify malignant disease at the earliest possible stage and intervention to ‘stop the oral cancer clock’ and halt the progression of this deadliest of oral diseases.
Author: Publisher: Academic Press ISBN: 0080581307 Category : Medical Languages : en Pages : 734
Book Description
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. Contains cutting-edge information on focused topics written by expert scientists Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines Attempts molecular pathophysiology which links basic science and the clinic Presents critical assessment of controversial topics
Author: Barbara Driscoll Publisher: Springer Science & Business Media ISBN: 1592593240 Category : Medical Languages : en Pages : 805
Book Description
This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer—both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.
Author: Maria A. Livrea Publisher: Birkhäuser ISBN: 3034884540 Category : Medical Languages : en Pages : 301
Book Description
Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.
Author: Guy R. Newell
Author: Guy R. Newell
Author: University of Texas M.D. Anderson Cancer Center
Author: United States. Public Health Service. Office of the Surgeon General
Author: Peter Thomson
Author: Ronald L. Gordner
Author: 
Author: 
Author: 
Author: Barbara Driscoll
Author: Maria A. Livrea