Author: M. Kalimi
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110847388
Category : Science
Languages : en
Pages : 460

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Book Description
No detailed description available for "The Biologic Role of Dehydroepiandrosterone (DHEA)".

Author: Nuel Nenji
Publisher: Independently Published
ISBN:
Category : Health & Fitness
Languages : en
Pages : 0

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Book Description
Both the adrenal glands, which are situated on top of each kidney, are responsible for the production of the steroid hormone known as dehydroepiandrosterone (DHEA). It has a role in the creation of other hormones, such as testosterone and estrogen, by acting as a precursor. As people get older, their levels of DHEA tend to steadily decrease after reaching their peak in early adulthood. Over the years, DHEA has garnered attention in a variety of fields, including the control of mood, the process of aging, and overall health and wellness. On the other hand, some individuals take DHEA supplements in an effort to improve their athletic performance or to address concerns that are associated with aging. On the other hand, the scientific evidence that supports the usefulness and safety of DHEA supplementation is not absolutely conclusive, and the effects that occur over a longer period of time are not completely known. It is essential to keep in mind that DHEA is regarded as a prohibited substance in certain countries; hence, the inclusion of this ingredient in dietary supplements must to be addressed with caution. When contemplating the use of any hormonal supplement, it is recommended to first consult with a qualified medical practitioner in order to evaluate the potential risks and benefits of the supplement based on the specific health requirements and conditions of the individual.

Author: Gerald Litwack
Publisher: Academic Press
ISBN: 0128143622
Category : Science
Languages : en
Pages : 462

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Book Description
Dehydroepiandrosterone, Volume 108, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics such as Dehydroepiandrosterone Research: Past, Current and Future, Astrocyte Neuroprotection and Dehydroepiandrosterone, Mutation of HSD3B2 Gene and Fate of Dehydroepiandrosterone, Autophagy and Autophagic Cell Death: Uncovering New Mechanisms Whereby Dehydroepiandrosterone Promotes Beneficial Effects on Human Health, Dehydroepiandrosterone and Cardiovascular Disease, Dehydroepiandrosterone and Experimental Osteoarthritis, The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle, Mechanism of Action of Dehydroepiandrosterone, and more. Focuses on the newest aspects of hormone action in connection with diseases Lays the groundwork for the focus of new chemotherapeutic targets Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways

Author: Mohammed Kalimi
Publisher: Walter de Gruyter
ISBN: 3110811162
Category : Science
Languages : en
Pages : 441

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Book Description

Author: George M. Kapalka
Publisher: Academic Press
ISBN: 008095801X
Category : Psychology
Languages : en
Pages : 440

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Book Description
This volume assists practicing mental health professionals in expanding their knowledge about nutritional and herbal interventions that can be attempted as alternatives to prescription medications. Designed to provide guidance for non-medical caregivers treating children and adolescents who present with emotional and/or behavioral difficulties such as such as depression, anxiety, ADHD, sleep difficulties, impulsivity, distractibility, and other psychological and psychiatric disorders, the volume provides a comprehensive discussion of naturopathic solutions based on existing research. In areas where research is not extensive, conclusions are provided about potentially beneficial effects based on the specific pharmacologic action of the compounds. Dosage for specific age groups, schedules of administration, dietary considerations (i.e., whether or not to take the supplement with food), monitoring for response and adverse effects, signs of dangerous reactions, and the need to control interactions with other compounds (i.e., prescription medications) are thoroughly reviewed with regard to each supplement discussed in the book. Reviews specific psychological disorders (i.e. ADHD, depression, mania, anxiety, sleep difficulties, tic behaviors and autism) and the available data about their treatment with the use of nutritional and herbal supplements Provides rationale for the use of every specific compound with detailed recommendations tailored for each age group with regard to the dosage, frequency of administration, possible dangers and monitoring for side effects Discusses claims of efficacy used to market various products and ground those claims within fully vetted scientific research Discusses neurobiology, pharmacodynamics and pharmokinetics in detailed but accessible language *Non-medical clinicians with limited knowledge of medicine and pharmacology come away with understanding of key issues involved in Fully covers assessment, diagnosis & treatment of children and adolescents, focusing on evidence-based practices *Consolidates broadly distributed literature into single source and specifically relates evidence-based tools to practical treatment, saving clinicians time in obtaining and translating information and improving the level of care they can provide Detailed how-to explanation of practical evidence-based treatment techniques *Gives reader firm grasp of how to more effectively treat patients Material related to diversity (including race, ethnicity, gender and social class) integrated into each chapter *Prepares readers for treating the wide range of youth they will encounter in practice

Author: Robert Morfin
Publisher: CRC Press
ISBN: 0203301218
Category : Medical
Languages : en
Pages : 250

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Book Description
DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro

Author: George Fink
Publisher: Academic Press
ISBN: 0123750970
Category : Medical
Languages : en
Pages : 895

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Book Description
Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.

Author: Qianxing Mo
Publisher:
ISBN:
Category : Central nervous system
Languages : en
Pages : 316

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Book Description
Dehydroepiandrosterone (DHEA) is a multi-functional neurosteroid that has been implicated in a variety of biological effects in humans and other mammals. The mechanism of action of DHEA has not been fully elucidated, although it is under investigation as a replacement therapy for humans with DHEA Insufficiency based on reports suggesting beneficial effects ranging from anti-depression to neuroprotection. Controversy remains about the relative contribution of DHEA and its metabolites in its biological effects. This dissertation focuses on a comparative study of the genomic effects of DHEA and its metabolites in vitro, and identification of genes regulated by DHEA in vivo. The results indicated that DHEA, androstenediol and androstenedione produced typical genomic effects, including promoting AR-GFP intracellular trafficking and formation of nuclear clusters in COS-7 cells, and conferred AR transcriptional activity in a dose-dependent manner in transiently transfected CV-1 cells. In contrast, DHEAS, 7alpha-OH-DHEA, 7beta-OH-DHEA, and 7-oxo-DHEA were essentially without androgenic activity. The results confirmed that DHEA is intrinsically androgenic and demonstrated significant differences in androgenic activity among DHEA and its metabolites. In the hypothalamus, DHEA, like the strongest androgen DHT, significantly up-regulated the expression of two important neuropeptides: hypocretin (Orexin) and pro-melanin concentrating hormone precursor (Prepro-MCH), and delta type protein kinase C (PKCdelta), and down-regulated the expression of deleted in bladder cancer chromosome region candidate 1 (DBCCR1) and chitinase 3-like 3 (Chi3l3). Interestingly, DHT down-regulated the expression of PKCS in the hippocampus. The differential expression of Prepro-MCH, orexin, and PKCdelta was further confirmed by real-time RT-PCR. MCH and orexin are involved in the regulation of appetite and energy homeostasis, and PKCdelta and DBCC1 are involved in regulation of cell growth, proliferation or survival. More importantly, the functions of these genes may explain the multiple effects of DHEA in humans and rodents. The findings may be of clinical significance and provide a new level of detail concerning the mechanism of action of DHEA in the central nervous system.

Author: Ray Sahelian
Publisher: Avery
ISBN: 9780895297747
Category : Adrenocortical hormones
Languages : en
Pages : 176

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Book Description
Natural Hormone, Disease, Mood and energy, and more.

Author: Ronald R. Watson
Publisher: CRC Press
ISBN: 9789057024559
Category : Medical
Languages : en
Pages : 164

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Book Description