The Biochemistry of Myasthenia Gravis and Muscular Dystrophy PDF Download

Author: George G. Lunt
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 396

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Author: Deborah Cavel-Greant
Publisher: Calgary : D. Cavel-Greant
ISBN:
Category : Myasthenia gravis
Languages : en
Pages : 216

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Author: Lewis P. Rowland
Publisher:
ISBN:
Category :
Languages : en
Pages : 5

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Author: Premkumar Christadoss
Publisher: Springer Science & Business Media
ISBN: 940114060X
Category : Medical
Languages : en
Pages : 220

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Book Description
Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.

Author: Mark A. Agius
Publisher:
ISBN:
Category : Myasthenia gravis
Languages : en
Pages : 584

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Book Description
Myasthenia gravis is the best-understood autoimmune disorder and its intense investigation has provided insights into the pathogenesis of autoimmune disease in general and the basic mechanisms of synaptic transmission. The papers in this volume report research findings on the mechanisms of disease, diagnosis and treatment of myasthenia gravis and related diseases. Other papers examine the advances in knowledge about the physiology, biochemistry, genetics, and the structure of the neuromuscular junction as well as advances in the immunology of pre-and post-synaptic disorders of the junction. Papers also discuss the clinical management of myasthenia gravis and related disorders.

Author: National Institute of Neurological and Communicative Disorders and Stroke
Publisher:
ISBN:
Category : Muscular dystrophy
Languages : en
Pages : 16

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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Feza Deymeer
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805570562
Category : Medical
Languages : en
Pages : 205

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Book Description
This book reviews the electrophysiological, genetic and immunological bases of some of the major neuromuscular diseases and evaluates their importance pertaining to the clinical management of the patients. Included are up-to-date topics such as gene therapy, myoblast transfer and new drug trials. Written by experts in their own fields, this volume will not only be of great value to neurologists and neuroscientists, but also to geneticists, immunologists and physiologists.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Nicholas J. Silvestri
Publisher: Karger Medical and Scientific Publishers
ISBN: 1910797537
Category : Medical
Languages : en
Pages : 49

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Book Description
An in-depth look at a rare disease Myasthenia gravis (MG) is a rare autoimmune disorder of the neuromuscular junction, characterized by muscle fatigability. Patients often initially present with ocular symptoms, but in most cases the disease spreads beyond the eye muscles to more generalized involvement of bulbar, facial, neck, proximal limb and respiratory muscles. With adequate treatment, most patients with MG are able to live productive lives with few or no symptoms, but a distinct subset of patients do not respond to conventional treatment. With new treatment options on the horizon, it is important that these patients are identified. 'Fast Facts: Recognizing Refractory Myasthenia Gravis' takes an in-depth look at: • the immune-mediated nature of MG • classification of MG by disease type and severity, and antibody status • clinical presentation and diagnostic work-up • conventional management options • how patients with treatment-refractory MG present • the assessment tools that can be used to identify non-responders. This informative resource will be of value to neurologists, neurology trainees and ophthalmologists caring for patients with this rare disease, as well as patients with MG who wish to have a deeper dialog with their doctor or patient group. Contents: • Definition and epidemiology • Pathophysiology and classification • Diagnosis and management: an overview • Assessment of disease severity and treatment response