The Acoustic Startle Response, Prepulse Inhibition, and Hearing-loss-induced Plasticity PDF Download

Author: Stephanie K. Carlson
Publisher:
ISBN:
Category : Deafness
Languages : en
Pages : 266

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Author: Jennifer R. O'Steen
Publisher:
ISBN:
Category : Auditory pathways
Languages : en
Pages :

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ABSTRACT: In addition to genetic influences, peripheral hearing loss and central auditory processing factors must be taken into consideration.

Author: Patrick R. Hof
Publisher: Elsevier
ISBN: 008052558X
Category : Medical
Languages : en
Pages : 989

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Book Description
Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. - Organized by function, making it easy to find and understand the material - Addresses impairments both associated with diseases and not associated with diseases - Written by leading researchers in the field - Most comprehensive source of information on the neurobiology of aging

Author: Ted Abel
Publisher: Academic Press
ISBN: 0128018771
Category : Psychology
Languages : en
Pages : 470

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The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. - Provides a comprehensive overview of neurobiological aspects of schizophrenia - Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels - Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance - Elucidates connections between the various systems depicted, when possible

Author: Edward D. Levin
Publisher: CRC Press
ISBN: 1420004336
Category : Medical
Languages : en
Pages : 395

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The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Author: Christoph E. Schreiner
Publisher: Springer Science & Business Media
ISBN: 9780387220383
Category : Medical
Languages : en
Pages : 732

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Book Description
The inferior colliculus is essential for hearing. Connecting the auditory brain stem to sensory, motor, and limbic systems, the inferior colliculus is a critical midbrain station for auditory processing. Winer and Schreiner's The Inferior Colliculus is the first critical, comprehensive reference presenting the current knowledge of the inferior colliculus from a variety of perspectives, including anatomical, physiological, developmental, neurochemical, biophysical, neuroethological and clinical vantage points. Written by leading researchers in the field, the book is an ideal introduction to the inferior colliculus and central auditory processing for clinicians, otolaryngologists, graduate and postgraduate research workers in the auditory and other sensory-motor systems. About the Editors: Jeffery A. Winer is Professor of Neurobiology in the Department of Molecular and Cell Biology at the University of California at Berkeley. Christoph E. Schreiner is Professor and Vice-Chair in the Department of Otolaryngology and Member of the Coleman Memorial Laboratory and the W. M. Keck Center for Integrative Neurosciences at the University of California School of Medicine at San Francisco.

Author: James F. Willott, PhD
Publisher: Springer Publishing Company
ISBN: 0826117171
Category : Medical
Languages : en
Pages : 389

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Neurogerontology tells the story of how the aging brain affects all aspects of cognition and physical performance. It comprehensively links the principles and substance of neuroscience with gerontology and psychology. Written largely from a behavioral neuroscience perspective, Neurogerontology explores the functional relationships between the central nervous system and psychological phenomena of aging, including perception, arousal, learning, cognition, and motor behavior. Willot emphasizes healthy aging, but dementia and other pathological conditions are discussed when relevant. This evidence-based approach to the neuroscience of aging makes this a valuable reference for professionals, as well as an informative textbook for students in gerontology courses.

Author: Robert C. Eaton
Publisher: Springer Science & Business Media
ISBN: 9780306415562
Category : Medical
Languages : en
Pages : 408

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In the past fifteen years there has been considerable interest in neural circuits that initiate behavior patterns. For many types of behaviors, this involves decision-making circuits whose primary elements are neither purely sensory nor motor, but represent a higher order of neural pro cessing. Of the large number of studies on such systems, analyses of startle circuits compose a major portion, and have been carried out on systems found throughout the animal kingdom. Startle has been an im portant model because of the reliability of the behavioral act for laboratory study and the accessibility of the underlying neural circuitry. However, probably because of the breadth of the subject, this material has never been reviewed in a comprehensive way that presents the elements com mon to startle circuits in the different animal systems in which they occur. This book presents a diversity of approaches based on a broad back ground of animal groups ranging from the earliest nervous systems in cnidarians to the most recently evolved and advanced in mammals. The behaviors themselves are all short latency, fast motor acts, when consid ered on the time scale of the organism, and involve avoidance or evasion, although in some cases we do not yet completely understand their natural role. These behaviors occur in response to stimuli that have sudden or unexpected onset.

Author:
Publisher:
ISBN:
Category : Prosthesis
Languages : en
Pages : 758

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Author: Robert A. McArthur
Publisher: Academic Press
ISBN: 0080920411
Category : Science
Languages : en
Pages : 1367

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Book Description
Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for understanding fundamental neurobiology of CNS disorders and the application of this knowledge to CNS drug discovery, and clinical investigators involved in clinical trials, drug development and eventual registration of novel pharmaceuticals. Each volume of the Animal and Translational Models for CNS Drug Discovery series is dedicated to the development and use of animal models in key therapeutic areas in psychiatric, neurologic and reward deficit disorders. Each volume has introductory chapters expressing the view of the role and relevance of animal models for CNS drug discovery and development from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in relevant therapeutic areas and discusses the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. - Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process - Critical evaluation of animal and translational models improving transition from drug discovery and clinical development - Emphasizes what results mean to the overall drug discovery process - Explores issues in clinical trial design and conductance in each therapeutic area - Each volume is available for purchase individually.