Smith and Williams' Introduction to the Principles of Drug Design and Action, Third Edition PDF Download
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Author: H. John Smith Publisher: CRC Press ISBN: 9789057020377 Category : Medical Languages : en Pages : 578
Book Description
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Author: H. John Smith Publisher: CRC Press ISBN: 9789057020377 Category : Medical Languages : en Pages : 578
Book Description
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Author: Pharmaceutical Society of Great Britain. Department of Pharmaceutical Sciences Publisher: Rittenhouse Book Distributors ISBN: Category : Medical Languages : en Pages : 808
Author: Raymond C. Rowe Publisher: Amer Pharmacists Assn ISBN: 9781582121352 Category : Medical Languages : en Pages : 888
Book Description
An internationally acclaimed reference work recognized as one of the most authoritative and comprehensive sources of information on excipients used in pharmaceutical formulation with this new edition providing 340 excipient monographs. Incorporates information on the uses, and chemical and physical properties of excipients systematically collated from a variety of international sources including: pharmacopeias, patents, primary and secondary literature, websites, and manufacturers' data; extensive data provided on the applications, licensing, and safety of excipients; comprehensively cross-referenced and indexed, with many additional excipients described as related substances and an international supplier's directory and detailed information on trade names and specific grades or types of excipients commercially available.
Author: Michael J. Telepchak Publisher: Springer Science & Business Media ISBN: 1592592929 Category : Medical Languages : en Pages : 398
Book Description
This complete laboratory reference manual explains the principles behind solid phase extraction (SPE) and provides readily reproducible protocols for solving extraction problems in forensic and clinical chemistry. Numerous actual chromatograms, based on original research and diverse applications, demonstrate the technique and the results that can be achieved. Extensive appendices allow fast access to frequently needed information on reagents, the preparation of solutions and buffers, milliequivalent and millimode calculations, buffers and pKa for SPE, and a complete RapidTrace® technical manual. Each proven protocol is described in step-by-step detail and contains an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and on avoiding known pitfalls.
Author: Øyvind Lie Publisher: Elsevier ISBN: 1845694929 Category : Technology & Engineering Languages : en Pages : 646
Book Description
Global aquaculture production has grown rapidly over the last 50 years. It is generally accepted that there is limited potential to increase traditional fisheries since most fish stocks are well or fully exploited. Consequently increased aquaculture production is required in order to maintain global per capita fish consumption at the present level. Fish farming enables greater control of product quality and safety, and presents the possibility of tailoring products according to consumer demands. This important collection reviews safety and quality issues in farmed fish and presents methods to improve product characteristics.The first part of the book focuses on chemical contaminants, chemical use in aquaculture and farmed fish safety. After an opening chapter discussing the risks and benefits of consumption of farmed fish, subsequent contributions consider environmental contaminants, pesticides, drug use and antibiotic resistance in aquaculture. Part two addresses important quality issues, such as selective breeding to improve flesh quality, the effects of dietary factors including alternative lipids and proteins sources on eating quality, microbial safety of farmed products, parasites, flesh colouration and off-flavours. Welfare issues and the ethical quality of farmed products are also covered. The final part discusses ways of managing of product quality, with chapters on HACCP, monitoring and surveillance, authenticity and product labelling.With its distinguished editor and international team of contributors, Improving farmed fish quality and safety is a standard reference for aquaculture industry professionals and academics in the field. - Reviews safety and quality issues in farmed fish and presents methods to improve product characteristics - Discusses contaminants, persistent organic pollutants and veterinary drug residues and methods for their reduction and control - Addresses important quality issues, genetic control of flesh characteristics and the effects of feed on product nutritional and sensory quality
Author: H. John Smith
Author: H. John Smith
Author: Pharmaceutical Society of Great Britain. Department of Pharmaceutical Sciences
Author: Charles Owens Wilson
Author: Indian Chemical Society
Author: Raymond C. Rowe
Author: Charles Owens Wilson
Author: Michael J. Telepchak
Author: Øyvind Lie
Author: T. C. Daniels
Author: Pandey O.P. & Bajpai D.N. & Giri S.