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Author: Publisher: Academic Press ISBN: 9780128163634 Category : Science Languages : en Pages : 0
Book Description
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
Author: Publisher: Academic Press ISBN: 9780128163634 Category : Science Languages : en Pages : 0
Book Description
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
Author: Denis Lynn Publisher: Springer Science & Business Media ISBN: 1402082398 Category : Science Languages : en Pages : 627
Book Description
distances between groups of ciliates were as vast as significant hurdles to obtain copyright permissions the genetic distances between plants and animals for the over 1,000 required illustrations, and I put – THE major eukaryotic kingdoms at that time! the publication schedule ahead of this element. I continued to collaborate with Mitch, and in There are a number of significant illustrated guides 1991 my first “molecular” Magisterial student, to genera and species that have recently been pub- Spencer Greenwood, published an article estab- lished. References are made to these throughout lishing 1990 or thereabouts as the beginning of the book as sources that readers can consult for this the “Age of Refinement” – the period when gene aspect of ciliate diversity. A future project that I am sequencing techniques would deepen our under- contemplating is an illustrated guide to all the valid standing of the major lines of evolution within ciliate genera.
Author: Publisher: Academic Press ISBN: 0080573622 Category : Science Languages : en Pages : 604
Book Description
Tetrahymena thermophila is emerging as a powerful experimental system for functional genetics. The ciliated protozoan offers numerous advantages, not the least of which is the ability to eliminate any specific gene of interest and then to evaluate the effect of that mutation on the living cell. Past investigations with T. thermophila have yielded several key discoveries, including dynein, catalytic RNA, and telomerase. This volume is a comprehensive resource for using Tetrahymena in the laboratory and is aimed at persons already experienced, as well as newcomers to the organism. It covers both the biological background and essential protocols for investigators rapidly turning to Tetrahymena as the experimental system of choice. Key Features * Contains both theoretical and practical issues in 30 chapters contributed by the world authorities on Tetrahymena * Indispensible for both the novice and the experienced researcher * Overviews the history, cell biology, and genetics of the organism * Describes essential protocols on the growth of cells, genetic techniques, and how to look at the cells with the microscope * Illustrates how the methods can be applied to solve various cell biological problems * Reviews recently developed strategies for altering gene expression
Author: Joseph G. Gall Publisher: ISBN: Category : Science Languages : en Pages : 444
Book Description
The Molecular Biology of Ciliated Protozoa covers topics that are unique to ciliates, including major molecular progress, genetics, life history, and development of ciliates. Organized into 11 chapters, it focuses on the importance of ciliated protozoa as experimental organisms. The introductory chapter traces the ups and downs of ciliate biology, emphasizing the prominent role of the ciliates in early studies of cell structure, reproduction, and heredity. The book goes on to discuss ciliate genetics and conjugation, providing the basic biological framework for molecular studies of ciliate. Ch ...
Author: Kathleen Collins Publisher: Academic Press ISBN: 0123859670 Category : Science Languages : en Pages : 467
Book Description
This new volume of Methods in Cell Biology looks at Tetrahymena thermophila, a model organism in experimental biology. Covering sections on Systems perspectives and Operating principles, chapters are written by experts in the field. With cutting edge material, this comprehensive collection is intended to guide researchers of Tetrahymena thermophila for years to come. Covers sections on systems perspectives and operating principles Chapters are written by experts in the field Cutting-edge material, making this a truly comprehensive collection
Author: Sean R. Gallagher Publisher: John Wiley & Sons ISBN: 047094241X Category : Science Languages : en Pages : 679
Book Description
The latest title from the acclaimed Current Protocols series, Current Protocols Essential Laboratory Techniques, 2e provides the new researcher with the skills and understanding of the fundamental laboratory procedures necessary to run successful experiments, solve problems, and become a productive member of the modern life science laboratory. From covering the basic skills such as measurement, preparation of reagents and use of basic instrumentation to the more advanced techniques such as blotting, chromatography and real-time PCR, this book will serve as a practical reference manual for any life science researcher. Written by a combination of distinguished investigators and outstanding faculty, Current Protocols Essential Laboratory Techniques, 2e is the cornerstone on which the beginning scientist can develop the skills for a successful research career.
Author: Guenther Witzany Publisher: Springer ISBN: 3319322117 Category : Science Languages : en Pages : 375
Book Description
This is the first coherent description of all levels of communication of ciliates. Ciliates are highly sensitive organisms that actively compete for environmental resources. They assess their surroundings, estimate how much energy they need for particular goals, and then realise the optimum variant. They take measures to control certain environmental resources. They perceive themselves and can distinguish between ‘self’ and ‘non-self’. They process and evaluate information and then modify their behaviour accordingly. These highly diverse competences show us that this is possible owing to sign(aling)-mediated communication processes within ciliates (intra-organismic), between the same, related and different ciliate species (inter-organismic), and between ciliates and non-ciliate organisms (trans-organismic). This is crucial in coordinating growth and development, shape and dynamics. This book further serves as a learning tool for research aspects in biocommunication in ciliates. It will guide scientists in further investigations on ciliate behavior, how they mediate signaling processes between themselves and the environment.
Author: Jan Sapp Publisher: Oxford University Press ISBN: 0195364686 Category : Science Languages : en Pages : 283
Book Description
The scope and significance of cytoplasmic inheritance has been the subject of one of the longest controversies in the history of genetics. In the first major book on the history of this subject, Jan Sapp analyses the persistent attempts of investigators of non-Mendelian inheritance to establish their claims in the face of strong resistance from nucleo-centric geneticists and classical neo-Darwinians. A new perspective on the history of genetics is offered as he explores the conflicts which have shaped theoretical thinking about heredity and evolution throughout the century: materialism vs. vitalism, reductionism vs. holism, preformation vs. epigenesis, neo-Darwinism vs. new-Lamarckism, and gradualism vs. saltationism. In so doing, Sapp highlights competitive struggles for power among individuals and disciplinary groups. He accepts that political interests and general social contexts may directly affect scientific ideas, but develops the stronger thesis that social interests inside science itself are always involved in the content of scientific knowledge. He goes on to show that there are no neutral judges in scientific controversies and investigates the social strategies and methodological rhetoric used by scientists when they defend or oppose a particular theory. At the same time, Sapp illustrates the social constraints that ensure the high cost and risk of entertaining unorthodox theories in the sciences.
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Author: Denis Lynn
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Author: Joseph G. Gall
Author: Kathleen Collins
Author: August Weismann
Author: Sean R. Gallagher
Author: Guenther Witzany
Author: Jan Sapp
Author: Antonio M. Solé-Cava