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Author: Publisher: Academic Press ISBN: 0128016132 Category : Science Languages : en Pages : 446
Book Description
T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease. Brings together current knowledge from a wide variety of animal species and humans Presents commentary from authoritative experts, and includes many prominent scientists and their research Illuminates the connections between developmental biology, evolution, and human disease Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge
Author: Publisher: Academic Press ISBN: 0128016132 Category : Science Languages : en Pages : 446
Book Description
T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease. Brings together current knowledge from a wide variety of animal species and humans Presents commentary from authoritative experts, and includes many prominent scientists and their research Illuminates the connections between developmental biology, evolution, and human disease Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge
Author: Toshio Nakanishi Publisher: Springer Nature ISBN: 9811511853 Category : Medical Languages : en Pages : 374
Book Description
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Author: Adrienne Alecia Maxwell Publisher: ISBN: Category : Languages : en Pages : 248
Book Description
T-box genes encode a family of transcription factors that contain a conserved DNA-binding domain, the T-box, and have been shown to play a crucial role in various developmental processes. Two zebrafish T-box genes, no tail (ntl) and spadetail (spt), as well as their orthologs in other vertebrates, have been shown to play important roles in the specification and patterning of posterior mesoderm. While wild-type zebrafish embryos develop ~30 somites that will later differentiate into muscle and vertebrae, spt mutants lack the anterior 15-17 trunk somites, and ntl mutants lack a notochord and the posterior 15 tail somites. Interestingly, embryos mutant for both ntl and spt lack all trunk and tail mesoderm, including tissues that form in both single mutants, indicating Ntl and Spt have overlapping functions in specifying these structures. Despite the obvious importance of T-box factors in development, relatively few of their transcriptional targets have been identified and tested to examine their role in mediating posterior mesoderm development. Recently, microarray results published by our lab and others have generated an extensive list of genes up- or down-regulated by Ntl and Spt. For my thesis I have chosen to focus on characterizing the role of several of these potential targets: mesogenin (msgn1), which belongs to the bHLH family of transcription factors; T-box gene 6-like (tbx6l), itself a T-box protein; RNA binding motif protein 38 (rbm38), an RNA-binding protein; and integrin beta 5 (itgb5), an adhesion and signaling molecule. Through characterization of a null mutant, I have shown that msgn1 functions with spt to promote cell migration out of the tailbud, but is not essential for zebrafish development. Additionally, I have shown that depleting tbx6l by morpholino oligonucleotide results in perturbation of dorsal-ventral patterning during gastrulation as well as dose-dependent loss of tail mesoderm. I have also characterized the spatial and temporal expression patterns of rbm38 and itgb5 and shown that both genes are expressed in the presumptive mesoderm and tailbud, where they overlap with ntl and spt expression, consistent with a role in mesodermal development. Characterizing the functions of downstream targets will add to the gene regulatory network for specification of posterior mesoderm and help to detail the molecular mechanism of vertebrate posterior development in general.
Author: Sally A. Moody Publisher: Elsevier ISBN: 0080550711 Category : Science Languages : en Pages : 1094
Book Description
Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology. • Includes new research not previously published in any other book on the molecular genetic processes that regulates development • Chapters present a broad understanding on the application of animal model systems, allowing researchers to better treat clinical disorders and comprehend human development • Relates the application of new technologies to the manipulation of stem cells, causes of human birth defects, and several human disease conditions • Each chapter includes a bulleted summary highlighting clinical aspects of animal models
Author: The Royal Society Publisher: National Academies Press ISBN: 0309671132 Category : Medical Languages : en Pages : 239
Book Description
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author: Rajesh V. Thakker Publisher: Academic Press ISBN: 0128041986 Category : Science Languages : en Pages : 880
Book Description
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Author: Robert J. White Publisher: Springer Science & Business Media ISBN: 3662035189 Category : Science Languages : en Pages : 274
Book Description
This monograph reviews and summarizes the substantial body of work that has been published on the transcription by polymerase III over the past 5 years. Progress in this field has been very rapid since 1993, and this new edition incorporates all the recent developments and offers the reader a highly detailed analysis of the current state of research on this largest and most complex of the eukaryotic RNA polymerases.
Author: Manzoor M. Khan Publisher: Springer Science & Business Media ISBN: 0387779760 Category : Medical Languages : en Pages : 275
Book Description
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
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Author: Charalampos Rallis
Author: Toshio Nakanishi
Author: Adrienne Alecia Maxwell
Author: Sally A. Moody
Author: The Royal Society
Author: Giacomina Brunetti
Author: Rajesh V. Thakker
Author: Robert J. White
Author: Manzoor M. Khan