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Author: V.M. Monnier Publisher: Birkhäuser ISBN: 303485577X Category : Science Languages : en Pages : 26
Book Description
The present work was done, as concerns the chemical-synthetical part, at the Institute for Organic Chemistry of the University Basel under the supervision of Prof. Dr. M. Brenner, as concerns the biological part, at the Laboratory for Sleep Research of the Physiological Institute of the University under the supervision of Prof. Dr. M. Monnier. I should like to express my gratitude to PD Dr. G.A. Schoenenberger who suggested the subject of this thesis and provided precious advice for its realization. I am very much indebted to Prof. Dr. M. Brenner who directed the synthetic work of the tripeptide. I am also grateful to my father Prof. Dr. M. Monnier and his coworkers L. Dudler and R. Gachter who tested the activity of the synthetical tripeptide. I also thank M. Grogg, Bachem, Liestal, for his help as concerns hydrogenoly sis reactions and E. von Arx for amino acid analysis at the Chromatogra phie-Labor, Pharma-Forschung, CIBA-GEIGY AG, Basel. 7 Abbreviations The abbreviations for amino acid derivatives, protecting groups and further helper groups are employed according to the recommendations of the IUPAC-IUB Commis sion on Biochemical Nomenclature which are reported in Biochem. J. 126, 773-780 (1972). Amino acids without symbol for the direction of rotation have the L-configu ration.
Author: V.M. Monnier Publisher: Birkhäuser ISBN: 303485577X Category : Science Languages : en Pages : 26
Book Description
The present work was done, as concerns the chemical-synthetical part, at the Institute for Organic Chemistry of the University Basel under the supervision of Prof. Dr. M. Brenner, as concerns the biological part, at the Laboratory for Sleep Research of the Physiological Institute of the University under the supervision of Prof. Dr. M. Monnier. I should like to express my gratitude to PD Dr. G.A. Schoenenberger who suggested the subject of this thesis and provided precious advice for its realization. I am very much indebted to Prof. Dr. M. Brenner who directed the synthetic work of the tripeptide. I am also grateful to my father Prof. Dr. M. Monnier and his coworkers L. Dudler and R. Gachter who tested the activity of the synthetical tripeptide. I also thank M. Grogg, Bachem, Liestal, for his help as concerns hydrogenoly sis reactions and E. von Arx for amino acid analysis at the Chromatogra phie-Labor, Pharma-Forschung, CIBA-GEIGY AG, Basel. 7 Abbreviations The abbreviations for amino acid derivatives, protecting groups and further helper groups are employed according to the recommendations of the IUPAC-IUB Commis sion on Biochemical Nomenclature which are reported in Biochem. J. 126, 773-780 (1972). Amino acids without symbol for the direction of rotation have the L-configu ration.
Author: Publisher: Academic Press ISBN: 9780128127940 Category : Science Languages : en Pages : 0
Book Description
Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.
Author: W. Chan Publisher: OUP Oxford ISBN: 0199637245 Category : Science Languages : en Pages : 371
Book Description
Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
Author: J.-M. Ghuysen Publisher: Elsevier ISBN: 0080860877 Category : Science Languages : en Pages : 607
Book Description
Studies of the bacterial cell wall emerged as a new field of research in the early 1950s, and has flourished in a multitude of directions. This excellent book provides an integrated collection of contributions forming a fundamental reference for researchers and of general use to teachers, advanced students in the life sciences, and all scientists in bacterial cell wall research. Chapters include topics such as: Peptidoglycan, an essential constituent of bacterial endospores; Teichoic and teichuronic acids, lipoteichoic acids, lipoglycans, neural complex polysaccharides and several specialized proteins are frequently unique wall-associated components of Gram-positive bacteria; Bacterial cells evolving signal transduction pathways; Underlying mechanisms of bacterial resistance to antibiotics.
Author: Alain Tressaud Publisher: Elsevier ISBN: 0080558119 Category : Medical Languages : en Pages : 821
Book Description
Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics
Author: Jonathan Walton Publisher: Springer ISBN: 3319768220 Category : Science Languages : en Pages : 253
Book Description
Poisonous mushrooms have fascinated scientists and laypersons alike for thousands of years. Almost all mushroom fatalities are due to the genus Amanita, whose poetic common names (death cap, destroying angel) attest to their lethality. In his classic 1986 book, Theodor Wieland covered the state of our knowledge about the chemistry and biochemistry of the toxins of Amanita mushrooms up until that time, with a particular focus on the decades of chemical research by him and the Wieland dynasty (including his father, brother, brother-in-law, and cousin). Wieland’s book is now mainly of historical interest, with its exhaustive overview of the early chemical studies done without benefit of methods taken for granted by modern chemists. This book is a complete top-to-bottom revision of Wieland’s 1986 book. The material covers history, chemistry, and biology with equal thoroughness. It should be of interest to natural products chemists and biologists, professional and amateur mycologists, and toxicologists. The three scientific fields that are most relevant to the book are natural products chemistry, mycology, and fungal molecular genetics. Dr. Walton is an expert in all three. To maximize the broad utility and appeal of the book, care has been taken to define all technical terms specific to a particular discipline, so that, for example, mycologists will be able to understand the relevant chemistry, and chemists will be able to understand the relevant fungal biology.
Author: David O. Norris Publisher: Academic Press ISBN: 0123964652 Category : Science Languages : en Pages : 599
Book Description
Vertebrate Endocrinology represents more than just a treatment of the endocrine system-it integrates hormones with other chemical bioregulatory agents not classically included with the endocrine system. It provides a complete overview of the endocrine system of vertebrates by first emphasizing the mammalian system as the basis of most terminology and understanding of endocrine mechanisms and then applies that to non-mammals. The serious reader will gain both an understanding of the intricate relationships among all of the body systems and their regulation by hormones and other bioregulators, but also a sense of their development through evolutionary time as well as the roles of hormones at different stages of an animal's life cycle. - Includes new full color format includes over 450 full color, completely redrawn image - Features a companion web site hosting all images from the book as PPT slides and .jpeg files - Presents completedly updated and revitalized content with new chapters, such as Endocrine Disrupters and Behavioral Endocrinology - Offers new clinical correlation vignettes throughout
Author: V.M. Monnier
Author: V.M. Monnier
Author: Vincent M. Monnier
Author: Vincent M. Monnier
Author: Vincent M. Monnier
Author: 
Author: W. Chan
Author: J.-M. Ghuysen
Author: Alain Tressaud
Author: Jonathan Walton
Author: David O. Norris