Author: Roy J. DoylePublisher:
ISBN:
Category : Chirality
Languages : en
Pages : 372
Book Description
Synthesis of Chiral Multidentate Ligands Containing Arsenic and Phosphorus Donor Atoms
Author: Roy J. DoylePublisher:
ISBN:
Category : Chirality
Languages : en
Pages : 372
Book Description
I. The Synthesis of a Series of Ligands Containing Nitrogen and Phosphorus Or Arsenic Donor Atoms Within the Same Moiety
Author: John William CorrPublisher:
ISBN:
Category : Ligands
Languages : en
Pages : 260
Book Description
I. The Synthesis of a Series of Ligands Containing Nitrogen and Phosphorus Or Arsenic Donor Atoms Within the Same Moiety
Author: John William CorrPublisher:
ISBN:
Category : Coordination compounds
Languages : en
Pages : 260
Book Description
Synthesis of Chiral Tridentate Ligands Containing Nitrogen, Phosphorus, and Sulfur Donors
Author: Anthony Robert AmaroPublisher:
ISBN:
Category :
Languages : en
Pages : 424
Book Description
Synthesis and Characterization of Novel Ligands Containing Oxygen and Phosphorus Donor Atoms
Author: Matthew Thomas GreenfieldPublisher:
ISBN:
Category :
Languages : en
Pages : 100
Book Description
Synthesis and Coordinating Properties of Ligands Containing Both Silicon and Phosphorus as Donor Atoms
Author: Chen-yang LiuPublisher:
ISBN:
Category : Ligands
Languages : en
Pages : 356
Book Description
Novel Chiral Wide Bite Angle Ligands for Asymmetric Catalysis
Author: Christine Fee CzaudernaPublisher:
ISBN:
Category : Chirality
Languages : en
Pages : 242
Book Description
Achiral wide bite angle ligands have been shown to be highly active and to induce excellent chemo- and regioselectivities in many homogeneously catalyzed reactions. However, only a few examples of chiral wide bite angle ligands are known so far. A diphenyl ether backbone was selected to allow maximum synthetic versatility and potential for a modular approach to design and synthesize such chiral diphosphorus ligands. Three synthetic strategies have been explored in this thesis: i) introduction of chiral substituents in the ligand backbone, ii) the use of P-stereogenic donor atoms and iii) the synthesis of chiral mixed-donor ligands bearing chiral auxiliary groups on the phosphorus atoms. Functionalization of the 3,3'-positions of 2,2'-bis(diphenylphosphino)diphenyl ether by carboxylic acid or ether auxiliaries was achieved via straightforward four-step routes to generate a library of ligands that were tested in various catalytic reactions. In the Pd-catalyzed asymmetric allylic alkylation of l,3-diphenyl-2-propenyl acetate and cyclohexyl-2-enyl acetate with dimethyl malonate the enantioselectivity was found to depend on the size of the chiral auxiliary introduced within the diphenyl ether backbone and its proximity to the phosphorus donor groups and hence to the active metal centre. Two types of mixed donor bidentate diphosphorus ligands based on the diphenylether backbone have been established, i.e. phosphine-phosphite and phosphine-phosphonite derivatives. A small ligand library bearing different chiral auxiliaries was accomplished via straightforward syntheses that enable derivatization of the respective phosphite and phosphonite moieties in the final step. In the Rh-catalysed hydrogenation of several benchmark substrates high conversion and moderate to high enantioselectivities (up to 97% for dimethyl itaconate) were obtained. The enantioselectivity was influenced by the size of the ortho-substituent on the chiral auxiliary group of the phosphite or phosphonite fragment. Two modular synthetic approaches for the preparation of novel wide bite angle diphosphine ligands containing stereogenic P-atoms have been developed. Both protocols involved diphenylether as backbone and the chiral ephedrine based precursor (2R[subscript(P)],4S[subscript(C)],5R[subscript(C)])-oxazaphospholidine borane as initial auxiliary to induce chirality at phosphorus. Various novel diphosphines were isolated as highly enantioenriched compounds with dr-ratios up to 95:5.
Bulletin of the Chemical Society of Japan
Author: Nihon KagakkaiPublisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 1154
Book Description
Synthesis of New Ligands Based on Camphoric Acid
Author: Magdalena Uzarewicz-BaigPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
This PhD thesis is divided into three chapters: Introduction, Results and Discussion and Experimental Part. First part of chapter one is a review of compounds incorporating diamine moieties. Nowadays, it is one of the most investigated area of studies in several fields. Their uses in medicine and in chemistry will be discussed. However, attention will be refunded mainly on the use of diamines in organic synthesis as chiral auxiliaries, as chiral ligands in asymmetric synthesis or as organocatalysts. Additionally, the selected methods for their preparation will be given. In the second part of chapter one, the research area of the phosphorus-heteroatom heterocyclic compounds will be the main focus. This part of chapter one will present the cyclisation process of chiral diamines around the phosphorus atom. The cyclisation step affords heterocycles containing a trivalent or pentavalent stereogenic phosphorus atom. Finally, the application of these compounds in catalyzed transition metal transformations will be discussed. The investigation, presented in terms of the current thesis in chapter two, covers the preparation of various diamine ligands based on camphoric acid. The chiral diamine ligands with nitrogen atoms containing the same or different substituents will be described and their application in to the nitroaldol reaction presented which provides an easy access to chiral -nitroalcohols in high enantioselectivity up to 84% and excellent yield in up to 93%. The further transformations of the secondary chiral diamines into heterocycles containing phosphorus atom in quantitative yields in up to 97% without any purification and their application as ligands or as versatile chiral shift reagents will be also discussed in the second chapter. Lastly, the third chapter is the collection of experimental procedures and data of the presented work. ; eng
Author: Luca Vaghi