Author: Neel KamalPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Substitutued 4-OXO-4-Thienyl-2-Butenoic Acid Hydrazides
Author: Neel KamalSynthesis, Characterization and Biological Activity of Transition Metal Complexes of Substituted 2-pyrazolines
Author: Mamta DudejaSynthesis, Characterization and Biological Activity of Transition Metal Complexes of Some Novel Substituted Biguanides
Author: Shashi SinghChemical Abstracts
Author: Transition Metals in Total Synthesis
Author: Peter J. HarringtonPublisher: Wiley-Interscience
ISBN:
Category : Science
Languages : en
Pages : 520
Book Description
Examines the use of transition metal complexes as reagents for the synthesis of complex organic molecules. Presented here are total syntheses whose efficiency depends upon the unique reactivity patterns of organometallic complexes. For each total synthesis, the biological activity of the molecule is presented, followed by discussion of the principles of the organometallic processes involved.
Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of Substituted Benzoyl (N-substituted) Thiosemicarbazones
Author: Sanjay KumarSynthesis, Characterization and Biological Activity of Some Transition Metals with Schiff Based Derived from 2-thiophene Carboxaldehyde and Aminobenzoic Acid
Author: Publisher:
ISBN:
Category : Transition metal compounds
Languages : en
Pages :
Book Description
Synthesis, Characterization, Antitumor and Antimicrobial Activities of Heterocyclic Transition Metal Complexes
Author: Magdalena Karolina BuczkowskaPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Synthesis, Characterization, and Computational Studies of Unsaturated Transition Metal Complexes
Author: Lori Anne WatsonSynthesis, Characterization, and Catalytic and Biological Activities of a Mixed-ligand Cobalt(ii) Bipyridyl/diphenylazodioxide Complex
Author: Kylin Alice EmhoffPublisher:
ISBN:
Category :
Languages : en
Pages : 160
Book Description
Transition metal complexes have immense importance in the pharmaceutical industry. These types of complexes can be useful catalysts in the synthesis of medicinal compounds and can act as anticancer drugs. In these pharmaceutical applications, 1st-row transition metal-containing complexes offer certain advantages compared to their 2nd and 3rd-row transition metal counterparts. Our motivation was to investigate pharmaceutical applications of transition metal complexes containing both a 1st-row transition metal and unusual ligands to expand the knowledge of a class of complexes that could potentially be beneficial in the pharmaceutical industry. A class of rare ligands that piqued our interest was that of the diaryl azodioxides, cis-Ar(O)NN(O)Ar, which belong to the wider class of organic derivatives of nitric oxide (NO). Our synthesis and pharmaceutical applications of the azodioxide complex salt [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 have been able to significantly expand the knowledge of azodioxide complexes by displaying an unusual trigonal prismatic coordination geometry for cobalt(II) with only bidentate ligands, showing evidence of ligand-based redox activity, acting as an active catalyst in allylic amination/C0́2C double-bond transposition reactions, and selectively inducing apoptosis in SK-HEP-1 human liver adenocarcinoma cells. Importantly, catalytic and biological studies of [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 are ongoing, and focused on its potential for use in the pharmaceutical industry as a drug or catalyst for drug synthesis. Future work will involve comparing the catalytic and biological activities of [Co(bpy){Ph(O)NN(O)Ph}2](PF6)2 with other azodioxide complexes prepared by our group to identify structure-activity relationships and inform the design of more efficient catalysts and anti-cancer, pro-apoptotic agents.