Synthesis and Characterization of Fluorescence Lifetime Probe Library Constructed Using Quantum Dots and Organic Dyes in a Multicomponent Silica Shell PDF Download
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Author: Ashwin Melkote Kainkaryam Publisher: ISBN: 9781369851830 Category : Languages : en Pages : 53
Book Description
In the recent years, significant emphasis is dedicated towards the application of nanomaterials for targeted deliveries. Using the diverse optic properties of quantum dots and fluorescent dyes and the versatile advantages of silica shell such as being biocompatible, their ease of synthesis and their drug loading platforms, they are used in biomedical and biological applications. This project explains the synthesis and characterization of multiplexed nanoprobes which are used for cancer detection studies. The nanoprobes were synthesized with various sizes and aspect ratios, involving various fluorescent dyes with a wide range of lifetime., and with varied loading concentrations of dyes and quantum dots as cores to sandwiching dyes between a shell and a core.
Author: Ashwin Melkote Kainkaryam Publisher: ISBN: 9781369851830 Category : Languages : en Pages : 53
Book Description
In the recent years, significant emphasis is dedicated towards the application of nanomaterials for targeted deliveries. Using the diverse optic properties of quantum dots and fluorescent dyes and the versatile advantages of silica shell such as being biocompatible, their ease of synthesis and their drug loading platforms, they are used in biomedical and biological applications. This project explains the synthesis and characterization of multiplexed nanoprobes which are used for cancer detection studies. The nanoprobes were synthesized with various sizes and aspect ratios, involving various fluorescent dyes with a wide range of lifetime., and with varied loading concentrations of dyes and quantum dots as cores to sandwiching dyes between a shell and a core.
Author: Thomas Michael Barnard Publisher: ISBN: Category : Languages : en Pages : 90
Book Description
Quantum dots are semiconductor crystals less than ̃10 nm in diameter. At this size, regime quantum confinement effects become significant. With cadmium selenide for example, a strong fluorescence becomes evident in the visible range once the spheres approach this scale. This fluorescence emission wavelength can be tuned from blue-green to red by merely changing the diameter of the sphere. The fluorescent properties of CdSe quantum dots have been exploited in numerous applications such as microscopic biological imaging, where the quantum dots perform better than traditional organic dyes. We have synthesized a new hybrid material that combines the remarkable fluorescent attributes of quantum dots with the long-excited state lifetimes of lanthanide complexes. In this new material, the lanthanide that is attached to the quantum dot can absorb light from a very short laser pulse (̃ 5 nanoseconds) and stay excited for a long period of time (microseconds to milliseconds). Eventually the excitation energy from the lanthanide is transferred to the quantum dot causing the quantum dot to fluoresce, effectively lengthening the lifetime of the quantum dot by several orders of magnitude. Furthermore, the lifetime is a function of the separation between the lanthanide and the quantum dot. By adjusting the separation between them, the fluorescent lifetimes of the quantum dots could be tuned. One potential application for this new tunable material would be for making nanoscale barcodes.
Author: Susantha Ganegamage Publisher: ISBN: Category : Diagnostic imaging Languages : en Pages : 0
Book Description
Chapter 3 of this dissertation explores a hypothesis that leverages the seesaw photophysical model for N-aryl (2,3- and 1,8-) naphthalimides. The Heagy group initially developed this model to understand the dual fluorescence effect concerning the electron donor or electron-withdrawing substituents. This study envisions the design and synthesis of novel dual fluorescence molecules for a new class of N-aryl-phenanthridinone dyes. The applied photophysical model further investigates these dyes with a substitution pattern opposite naphthalimide systems. Interestingly, predictive computational modeling shows that the substituent pattern, used previously for 2,3-naphthalimides, relies on these groups getting placed on rings in opposite positions for N-aryl-phenanthridinones. Chapter 4, provides an overall conclusion of the and future directions for both parts of the research. In chapter 5, a complete description of experimental data is provided for the characterization of all the dye systems presented. This data includes a detailed synthesis procedure, characterization, purity analysis by HPLC, absorptivity calculation, fluorescence lifetime measurements, quantum yield determination, biological evaluation and fluorescence titration.
Author: Shuvasree Ray Publisher: ISBN: Category : Languages : en Pages :
Book Description
Fluorescent labeling of biological materials using small organic dyes is widely employed in the life sciences and have been used in a variety of applications that include diagnostics and imaging. Quantum dots have the potential to overcome problems encountered by organic molecules and have been exploited for applications in biological imaging and in single particle tracking studies. The dithiolane ring can be exploited to attach a diversity of organic compounds to CdSe-ZnS core-shell nanoparticles. The introduction of spectroscopic labels as trans-azobenzene chromophores offers the opportunity to quantify the average number of dithiolane anchoring groups attached to each quantum dot. The transition from monomeric ligands with a single dithiolane anchor to polymeric ligands with multiple dithiolane anchoring groups can be exploited to raise the number of chromophoric labels adsorbed on each quantum dot. Systems showing FRET have been developed on the basis of supramolecular association of BODIPY based dyes or quantum dots as donors and organic chromophores as acceptors. Amino - terminated dyes and quantum dots associate with the chromophores through an ammonium moiety on addition of acid, thereby bringing them closer. Addition of base increases back the fluorescence intensity of the donor completely because of the dissociation. However a similar system with quantum dots as donor, show a very small restoration of fluorescence possibly due to non-specific interaction. In the next project, introduction of spectroscopic labels, in the form of BODIPY dye within the ligands offered the opportunity to quantify the average number of dithiolane anchoring groups attached to each quantum dot. Both fluorescence resonance energy transfer and electron transfer mechanisms are responsible for the quenching of quantum dot fluorescence and unfortunately does not make the system suitable for pH sensing. In the final project, BODIPY-oxazine based fluorophore - photochrome dyad has been assembled by a connecting triazole ring, such that the emission of the former can be modulated by the electronic and structural changes caused by the photoinduced transformations of the later. Further experiments need to be conducted on the fluorophore - photochrome dyads to switch the luminescence of the former with optical inputs.
Author: R. W. Sabnis Publisher: John Wiley & Sons ISBN: 1118028694 Category : Science Languages : en Pages : 468
Book Description
A COMPLETE, UP-TO-DATE RESOURCE OF INFORMATION ON MORE THAN 150 FLUORESCENT DYES AND PROBES Handbook of Fluorescent Dyes and Probes is the most comprehensive volume available on the subject, covering all the available dyes and probes known to date in the literature for uses in various fields. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, color, material, physical and related allied fields. The ease of use of the handbook is further enhanced by various appendixes provided at the end of the book to conveniently and easily locate the dye as per the reader's need. This is the first book to give the CAS registry numbers, chemical structure, Chemical Abstract (CA) index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pKa, absorption maxima, emission maxima, molar extinction coefficient, and quantum yield of fluorescent dyes and probes, as well as to provide access to synthetic procedures (lab scale and industrial scale) of dyes and probes in a single source. This user-friendly handbook also features references on safety, toxicity and adverse effects of dyes and probes on humans, animals and the environment, including: acute/chronic toxicity aquatic toxicity carcinogenicity cytotoxicity ecotoxicity genotoxocity hematotoxicity hepatotoxicity immunotoxicity marine toxicity microbial toxicity mutagenicity nephrotoxicity neurotoxicity nucleic acid damage oral toxicity phototoxicity phytotoxicity reproductive toxicity skin toxicity Containing imaging/labeling applications, biological/medical applications and industrial applications, Handbook of Fluorescent Dyes and Probes is a convenient, vital resource for industrial and academic researchers, and a valuable desktop reference for medical professionals, lab supervisors, scientists, chemists, biologists, engineers, physicists, intellectual property professionals, students, and professors. Includes all fluorescent dyes & probes known to date and provides a complete, up-to-date library of information in one reference/handbook Includes more than 300 fluorescent dyes & probes organized alphabetically by the commonly used Chemical Name Provides access to synthesis procedures (lab scale and industrial scale) of fluorescent dyes & probes First book to provide references on safety, toxicity and adverse effects of fluorescent dyes and probes on humans, animals, and the environment User-friendly and convenient resource guide for chemical, biological, medical, and intellectual property professionals in a broad range of disciplines
Author: Jun-Jie Zhu Publisher: Springer Science & Business Media ISBN: 3642449107 Category : Technology & Engineering Languages : en Pages : 96
Book Description
This book provides a broad introduction to all major aspects of quantum dot properties including fluorescence, electrochemical, photochemical and electroluminescence. Such properties have been produced for applications in biosensing, cell tracking, in vivo animal imaging and so on. It focuses on their special applications in DNA biosensing and provides readers with detailed information on the preparation and functionalization of quantum dots and the fabrication of DNA biosensors, using examples to show how these properties can be used in DNA biosensor design and the advantages of quantum dots in DNA biosensing. Further new emerging quantum dots such as metal nanoclusters and graphene dots and their applications in DNA biosensing have also been included.
Author: Puspendu Barik Publisher: Springer Nature ISBN: 9811931445 Category : Technology & Engineering Languages : en Pages : 274
Book Description
This book illustrates various applications of quantum dots (QDs) in the biomedical field and future perspectives. It first introduces the synthesis procedures and fundamental properties of QDs. In addition, the optical detection techniques and toxicologic reviews of QDs are presented. A focus of the book is also on the applications of QDs in cancer therapy, drug delivery, bio-sensing, and targeted molecular therapy. This book is exciting and valuable to a wide variety of readership communities (students, early-stage researchers, and scientists) in the various fields of biology and medicine.
Author: Inamuddin Publisher: Materials Research Forum LLC ISBN: 1644901242 Category : Technology & Engineering Languages : en Pages : 360
Book Description
The book provides a thorough survey of current research in quantum dots synthesis, properties, and applications. The unique properties of these new nanomaterials offer multifunctional applications in such fields as photovoltaics, light-emitting diodes, field-effect transistors, lasers, photodetectors, solar cells, biomedical diagnostics and quantum computing. Keywords: Quantum Dots (QD), Photovoltaics, Light-emitting Diodes, Field-effect Transistors, Lasers, Photodetectors, Solar Cells, Biomedical Diagnostics, Quantum Computing, QD Synthesis, Carbon QDs, Graphene QDs, QD Sensors, Supercapacitors, Magnetic Quantum Dots, Cellular/Molecular Separation, Chromatographic Separation Column, Photostability, Luminescence of Carbon QDs, QD Materials for Water Treatment, Semiconductor Quantum Dots, QD Drug Delivery, Antibacterial Quantum Dots.
Author: Ashwin Melkote Kainkaryam
Author: Ashwin Melkote Kainkaryam
Author: Thomas Michael Barnard
Author: Susantha Ganegamage
Author: Shuvasree Ray
Author: R. W. Sabnis
Author: Jason Michael Horst
Author: Jun-Jie Zhu
Author: Puspendu Barik
Author: Inamuddin
Author: Richard Alan Bley