Author: Asad HashmiPublisher:
ISBN:
Category : Ligands
Languages : en
Pages : 0
Book Description
Synthesis and characterization of bismetalated platinum complexes containing benzothiophene functionalized ligands
Author: Asad HashmiSynthesis and characterization of platinum(II) complexes from quinoline or pyridine functionalized benzothiophene ligands
Author: Leila DumanSynthesis, characterization, and photophysical properties of platinum complexes with benzothiophene ligands
Author: Michael WeinsteinPublisher:
ISBN:
Category : Catalysis
Languages : en
Pages : 0
Book Description
Synthesis and characterization of platinum(II) complexes with thiophene-based ligands
Author: Julienne SarabiaPublisher:
ISBN:
Category : Ligands
Languages : en
Pages : 0
Book Description
Synthesis and Characterization of Platinum (II) Complexes with Sulfur- and Nitrogen- Containing Ligands
Author: Jun WenSynthesis, Characterization, and Photophysical Properties of Cyclometalated N-Heterocyclic Carbene Platinum(II) Complexes
Author: Francesco MastrocinquePublisher:
ISBN:
Category : Carbenes
Languages : en
Pages : 0
Book Description
Thiophene and benzothiophene ligands containing N-heterocyclic carbene (NHC) moieties were used to synthesize five and six-membered Pt(II) metallacycles. Ligand scaffolding was synthesized using two methods. The five-membered metallacycles were produced using a coupling reaction, utilizing Cu2O as the inorganic catalyst. The six-membered metallacycles were synthesized using a nucleophilic substitution reaction. The ligands were then metalated using chelate-assisted C-H activation. The synthesis, characterization, and photophysical properties of these NHC-functionalized, cyclometalated products are reported.
Rational Design, Synthesis and Characterization of Amide Functionalized Pyridine and Benzimidazole Transition Metal Complexes
Author: Samuel S. K. AsemPublisher:
ISBN:
Category : Benzimidazoles
Languages : en
Pages : 576
Book Description
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and benzimidazole ligands. These heterocycles, amide functionalized at position 2 with aryl and alkyl pendants, rapidly change their mode of coordination depending on the pH of the medium. These ligands, synthesized using condensation chemistry, also coordinate to Co(II), Ni(H), Cu(lI), and Zn(1I) generally as anionic bis-chelates through the benzimidazole nitrogen and the carbonyl oxygen, creating a four-coordinate complex with the exception of an unusual trigonal bipyramidal Zn(H) complex. I H NMR temperature studies reveal that these ligands interconvert between imide and amide isomers and that electron withdrawing pendants favor amide isomers. Crystal structures of Co(II) and Ni(1I) complexes of N-( I-methylbenzimidazol-2-yl)cyclohexanecarboxamide, for example, show two ligands bind per metal ion when reacted with acetate and nitrate salts. The bischelates of these Ni(1I) complexes also show expansions of their coordination spheres from four to five-coordinate. Furthermore, these Ni(II) bis-chelated complexes possess square planar or distorted 4-coordinate geometries. The synthesis and properties of several new Pt (II) complexes containing these ligands will be presented. A second generation and novel complex class containing metal-binding, linker and recognition domains is reported. Both classes of Pt complexes were obtained using a synthetic methodology which favors the cis isomers. The second generation complex crystallizes in the monoclinic space group P2dn with lattice dimensions a = 17.7393(5) A, b = 11.4632(3) A, c = 19.3959(5) A and ~ = 99.794(3)°. These complexes have been characterized using physical methods that include X-ray crystallography, IH &13C NMR, Mass spectrometry, UV and IR spectroscopies. Complexes similar in structure to cisplatin and carboplatin show varying cytotoxic properties toward different cancer cell lines. Additionally, some of these new Pt complexes show comparable and promising cytotoxicity against prostate cancer cell lines.
The Synthesis and Characterization of Platinum Complexes Containing Thiolate and Catenated Polysulfur Ligands
Author: Rabin Diwan LaiPublisher:
ISBN:
Category : Ligands
Languages : en
Pages : 346
Book Description
"The first platinadisulfanes, complexes of the type cis-(PPh(,3))(,2)Pt(Npht)(SSR''), where R'' = ('n)Pr, ('i)Pr, CH(,2)Ph, 4-C(,6)H(,4)Me and Npht, were synthesized in good yield by the oxidative addition of R''SSNpht to (PPh(,3))(,2)Pt(C(,2)H(,4)). Similarly, addition of R''SNpht gave cis-(PPh(,3))(,2)Pt(Npht)(SR'')." --
Synthesis and Characterization of Platinum(II) Complexes with Adamantantanamine Derivatives and Related Ligands
Author: Monique DoyonPublisher:
ISBN:
Category :
Languages : en
Pages : 356
Book Description
"New platinum(II) complexes of the type (Pt(A$ sp prime$)Cl$ sb3 rbrack sp-$, Pt(A)(A$ sp prime$)Cl$ sb2$ and Pt(A)(A$ sp prime$)I$ sb2$, where A = methylamine, ethylamine, cyclobutylamine and cyclopentylamine and A$ sp prime$ = 1-adamantanamine, 2-adamantanamine and 1-methyladamantanamine have been synthesized. The structure of (2-adamH) (Pt(EtNH$ sb2$)Cl$ sb3$) complex has been determined by X-ray diffraction." --
Synthesis and Characterisation of Ortho-metallated Platinum Complexes Containing Tertiary Phosphine and Arsine Donor Ligands
Author: Steven H. PrivérPublisher:
ISBN:
Category : Complex compounds
Languages : en
Pages : 424
Book Description