Author: Anabela Raymundo
Publisher: Springer Nature
ISBN: 3031672178
Category :
Languages : en
Pages : 200

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Book Description

Author: H. Goslinga
Publisher: Springer Science & Business Media
ISBN: 3642692605
Category : Medical
Languages : en
Pages : 214

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Book Description
The hemodynamic significance of the flow properties of blood was put into perspective only during the past decade. Advances in modern technologies today allow the quantitative analy sis of the fluidity of blood and its components under conditions approximating the flow in vivo, particularly those in the microcirculation. The hematocrit is the most important of the determinants of blood fluidity (reciprocal value of blood viscosity); acute increases in the hematocrit exert deleterious effects on circulation and oxygen transport owing to impaired fluidity of blood. High viscosity of plasma due to hyper- or dysproteinemias initiates the microcirculatory dysfunctions in hyperviscosity syndromes. Furthermore, the fluidity or deformability of red cells might be critically diminished and therefore cause redistribution of blood elements and adversely affect the resistance to flow within the microvessels. In low flow states blood fluidity most likely becomes the key determinant for microvessel perfu sion, overriding the neural and local metabolic control mechanisms operative at physiological conditions to adjust blood supply to tissue demand. Microcirculatory disturbances are there fore encountered whenever driving pressures are reduced, as in shock or hypotension, and distal to stenoses of macrovessels, but also in hemoconcentration due to plasma volume con traction, polycythemia, leukemia, and dysproteinemia. Based on experimental studies exploring the possibilities and limitations, with regard to improving the fluidity of blood by reducing the hematocrit, the concept of intentional hemo dilution has been introduced to clinical medicine.

Author: M. Bessis
Publisher: Springer Science & Business Media
ISBN: 3642670598
Category : Science
Languages : en
Pages : 418

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Book Description
Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2].

Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712

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Book Description
First multi-year cumulation covers six years: 1965-70.

Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :

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Book Description
First multi-year cumulation covers six years: 1965-70.

Author: Leopold Dintenfass
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 420

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Book Description

Author: L. Dintenfass
Publisher: Springer Science & Business Media
ISBN: 9780852004135
Category : Medical
Languages : en
Pages : 502

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Book Description

Author: S. Chien
Publisher: Springer Science & Business Media
ISBN: 9400942850
Category : Medical
Languages : en
Pages : 556

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Book Description
The task the editors have set themselves is to survey the field of clinical hemorheology from basic principles to up-to-date research. It is only in a new science like this that it is possible to span the whole field in a book of this size. Hemorheology, as a new approach to the study and management of a wide range of circulatory diseases, is now beginning to appear with increasing frequency in general as well as specialized medical journals. Hemorheology is also just beginning to creep into the undergraduate medical curriculum. Therefore, the majority of graduate doctors are unequipped to assess the place of hemorheology in the overall framework of circulatory physiology and pathology or to assess its relevance to their everyday practice. It is hoped that this book will fill this gap. The approach of the book is interdisciplinary. The first part deals with basic principles of blood flow, circulation and hemorheology. It has been written with the general doctor in mind, who has no special knowledge of hemodynamics and rheological concepts, terminology or methodology. To maintain the emphasis on practical clinical applications, all the chapters in the second part of the book have been written by clinical specialists practicing in the individual areas of disease. The book is so designed that clinicians may be able to read the relevant chapters in the second part of the book in isolation, using the basic science aspects contained in the first part of the book as reference chapters.

Author: Daniel Hershey
Publisher: Springer Science & Business Media
ISBN: 1468418572
Category : Medical
Languages : en
Pages : 384

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Book Description
Under the broad heading of blood oxygenation there may be specific areas of study, such as the kinetics of the oxygen hemoglobin reaction, diffusion of gases through the red cell, blood preservation, blood chemistry, oxygen electrode design and the design and evaluation of artificial blood oxygenators. ~lood oxygenation is of interest to many disciplines including physicians, chemists, physicists, biologists, physiologists and engineers. The International Symposium on Blood Oxygenation was or ganized in order to bring together the people working in the various areas of blood oxygenation. This multidiscipline meet ing was held at the University of Cincinnati on December 1, 2 and 3 of 1969. It was jOintly sponsored by the U. S. Army Medi cal Research and Development Command and the University of Cin cinnati. Participants came from Australia, England, Israel, Italy, Japan and the United States. There were 122 persons registered for the Symposium. From the nature of the discussion during the meeting, it seemed apparent that the participants were benefiting from the contacts with colleagues in other disciplines. The result was a significant contribution to the present fund of knowledge of blood oxygenation and an enhancement of the future work.

Author: Y. C. Fung
Publisher: Springer Science & Business Media
ISBN: 1475722575
Category : Medical
Languages : en
Pages : 585

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Book Description
The objective of this book remains the same as that stated in the first edition: to present a comprehensive perspective of biomechanics from the stand point of bioengineering, physiology, and medical science, and to develop mechanics through a sequence of problems and examples. My three-volume set of Bio mechanics has been completed. They are entitled: Biomechanics: Mechanical Properties of Living Tissues; Biodynamics: Circulation; and Biomechanics: Motion, Flow, Stress, and Growth; and this is the first volume. The mechanics prerequisite for all three volumes remains at the level of my book A First Course in Continuum Mechanics (3rd edition, Prentice-Hall, Inc. , 1993). In the decade of the 1980s the field of Biomechanics expanded tremen dously. New advances have been made in all fronts. Those that affect the basic understanding of the mechanical properties of living tissues are described in detail in this revision. The references are brought up to date.