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Author: Gilberto Igrejas Publisher: Frontiers Media SA ISBN: 2889633802 Category : Languages : en Pages : 718
Book Description
In January of 2015, under the 1st International Caparica Conference in Antibiotic Resistance, a Research Topic entitled: “Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to overcome”, was published (http://journal.frontiersin.org/researchtopic/3763/surveying-antimicrobial-resistanceapproaches- issues-and-challenges-to-overcome). The problem of antimicrobial resistance (AMR), caused by excessive and inappropriate use of antibiotics, is a public health issue that concerns us all. The introduction of penicillin in the 1940s, the start of the antibiotics era, has been recognized as one of the greatest advances in therapeutic medicine. However, according to the World Health Organization (WHO), AMR infections are now an increasing worldwide public health threat and a post-antibiotic era is imminent, where common infections and minor injuries could be fatal. AMR is a typical ‘One Health’ problem, in which livestock animals and the environment constitute AMR reservoirs and transmission routes to and from the human population. Without effective antimicrobials to counter and prevent infections, other major achievements in modern medicine, such as organ transplantation, cancer chemotherapy and major surgery, risk being compromised. AMR infections in animals have negative outcomes on animal health, welfare, biosecurity and production. In 2006, the ban of growth promoting antibiotics highlighted antibiotic use in animal production as a risk factor in the development of antibiotic resistant bacteria. Bacteria can be transferred to humans via several routes; consumption of animal products, exposure through contact with animals, and the contamination of ground and surface waters by animal waste products. Therefore, it is of utmost importance that antimicrobial use in animals is reduced to a minimum, without compromising animal health and welfare. Mechanisms of bacterial antibiotic resistance are classified according to the types of antibiotic molecules or their targets in the cell. Environmental antibiotic-resistance genes are spread then acquired by clinically relevant microorganisms. Many resistance genes are conveyed into pathogen genomes via mobile genetic elements such as plasmids, transposons or integrons, increasing the propagation of potential resistant pathogens. Substantial progress has already been made in elucidating the basic regulatory networks that endow bacteria with their extraordinary capacity to adapt to a diversity of lifestyles and external stress factors. So how will we face bacteria in the future?
Author: Gilberto Igrejas Publisher: Frontiers Media SA ISBN: 2889633802 Category : Languages : en Pages : 718
Book Description
In January of 2015, under the 1st International Caparica Conference in Antibiotic Resistance, a Research Topic entitled: “Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to overcome”, was published (http://journal.frontiersin.org/researchtopic/3763/surveying-antimicrobial-resistanceapproaches- issues-and-challenges-to-overcome). The problem of antimicrobial resistance (AMR), caused by excessive and inappropriate use of antibiotics, is a public health issue that concerns us all. The introduction of penicillin in the 1940s, the start of the antibiotics era, has been recognized as one of the greatest advances in therapeutic medicine. However, according to the World Health Organization (WHO), AMR infections are now an increasing worldwide public health threat and a post-antibiotic era is imminent, where common infections and minor injuries could be fatal. AMR is a typical ‘One Health’ problem, in which livestock animals and the environment constitute AMR reservoirs and transmission routes to and from the human population. Without effective antimicrobials to counter and prevent infections, other major achievements in modern medicine, such as organ transplantation, cancer chemotherapy and major surgery, risk being compromised. AMR infections in animals have negative outcomes on animal health, welfare, biosecurity and production. In 2006, the ban of growth promoting antibiotics highlighted antibiotic use in animal production as a risk factor in the development of antibiotic resistant bacteria. Bacteria can be transferred to humans via several routes; consumption of animal products, exposure through contact with animals, and the contamination of ground and surface waters by animal waste products. Therefore, it is of utmost importance that antimicrobial use in animals is reduced to a minimum, without compromising animal health and welfare. Mechanisms of bacterial antibiotic resistance are classified according to the types of antibiotic molecules or their targets in the cell. Environmental antibiotic-resistance genes are spread then acquired by clinically relevant microorganisms. Many resistance genes are conveyed into pathogen genomes via mobile genetic elements such as plasmids, transposons or integrons, increasing the propagation of potential resistant pathogens. Substantial progress has already been made in elucidating the basic regulatory networks that endow bacteria with their extraordinary capacity to adapt to a diversity of lifestyles and external stress factors. So how will we face bacteria in the future?
Author: Gilberto Igrejas Publisher: Frontiers Media SA ISBN: 2889451410 Category : Languages : en Pages : 421
Book Description
Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017
Author: Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The "One Health" concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The "One Health" concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017.
Author: Donna U. Vogt Publisher: ISBN: Category : Medical Languages : en Pages : 100
Book Description
Antimicrobials -- a set of agents which includes antibiotics, synthetic anti-effective drugs, antibacterial agents, and disinfectants -- had had significant beneficial effects on public health, medicine, animal husbandry, agriculture, and food processing. By making many diseases and infections, which were once difficult to treat and often lethal, readily curable, antibiotics have revolutionised human and veterinary medicine. In agricultural use, besides treating specific infections in animals, antibiotics are also given to farm animals to speed their growth, to promote the efficient use of the feed, and to be sprayed on crops as pesticides. The widespread use of antimicrobials, however, is causing some to lose their ability to control disease. The Food and Drug Administration (FDA) approves antimicrobials for human and veterinary use if the manufacturer of the antimicrobial has met all FDA's safety and efficacy requirements. FDA's approval system is not designed to respond to the development of resistant strains, subsequent to approval of the product for human drugs. However, the federal government does run several surveillance programs designed to estimate the scope of the resistance problem, supports research directed at discovering new antibiotics or strategies to circumvent resistance, and promotes voluntary activities on the part of practitioners, consumers, and agricultural producers to reduce the risk. Legislative concerns regarding policies to control antimicrobial resistance focus on whether policy actions should seek to influence the root causes of the problem, encourage new treatments, or address its symptoms. Defining appropriate policy responses is particularly difficult given the complexity of the microbial resistance problem, the lack of data to assess the problems, and the disagreement over the seriousness of the extent of the health threat to resistance. Use of antimicrobials in human medicine, for example, is thought to be the primary source of resistance and some wonder whether the government should regulate such uses. Included in the debate are the uses of antibiotics in the agricultural sector. The conflict there is over how much antibiotic use, both for treating disease and promoting growth, in food-producing animals contributes to resistant strains of bacteria. FDA has proposed a framework in its animal drug approval system to ensure some tracking of resistance development if it takes place.
Author: Isabelle Pailliart Publisher: John Wiley & Sons ISBN: 1119706718 Category : Health & Fitness Languages : en Pages : 210
Book Description
The third volume in the “Health Information” set, New Territories in Health focuses on the multifaceted spheres of influence or “territories” in the field of health. This book includes nine contributions – based on the analysis of stakeholder logics – that approach the relationships between health and territories. The authors – all specialists – offer original insights, enhanced by in-depth studies, on the multiple forms that this territorialization takes: political and institutional, professional and organizational, public and media.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309060842 Category : Science Languages : en Pages : 128
Book Description
Antibiotic resistance is neither a surprising nor a new phenomenon. It is an increasingly worrisome situation, however, because resistance is growing and accelerating while the world's tools for combating it decrease in power and number. In addition, the cost of the problemâ€"especially of multidrug resistanceâ€"in terms of money, mortality, and disability are also rising. This book summarizes a workshop on antimicrobial resistance held by the Forum on Emerging Infections. The goal of the Forum on Emerging Infections is to provide an opportunity for representatives of academia, industry, government, and professional and interest groups to examine and discuss scientific and policy dilemmas of common interest that are specifically related to research on and the prevention, detection, and management of emerging infections. Organized as a topic-by-topic synthesis of presentations and exchanges during the workshop, the book highlights lessons learned, delineates a range of pivotal issues and the problems they raise, and proposes some simplified ideas about possible responses.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309675332 Category : Medical Languages : en Pages : 179
Book Description
On December 4â€"5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop.
Author: King K. Holmes Publisher: World Bank Publications ISBN: 1464805253 Category : Medical Languages : en Pages : 1027
Book Description
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author: National Research Council Publisher: National Academies Press ISBN: 0309316472 Category : Science Languages : en Pages : 264
Book Description
By 2050 the world's population is projected to grow by one-third, reaching between 9 and 10 billion. With globalization and expected growth in global affluence, a substantial increase in per capita meat, dairy, and fish consumption is also anticipated. The demand for calories from animal products will nearly double, highlighting the critical importance of the world's animal agriculture system. Meeting the nutritional needs of this population and its demand for animal products will require a significant investment of resources as well as policy changes that are supportive of agricultural production. Ensuring sustainable agricultural growth will be essential to addressing this global challenge to food security. Critical Role of Animal Science Research in Food Security and Sustainability identifies areas of research and development, technology, and resource needs for research in the field of animal agriculture, both nationally and internationally. This report assesses the global demand for products of animal origin in 2050 within the framework of ensuring global food security; evaluates how climate change and natural resource constraints may impact the ability to meet future global demand for animal products in sustainable production systems; and identifies factors that may impact the ability of the United States to meet demand for animal products, including the need for trained human capital, product safety and quality, and effective communication and adoption of new knowledge, information, and technologies. The agricultural sector worldwide faces numerous daunting challenges that will require innovations, new technologies, and new ways of approaching agriculture if the food, feed, and fiber needs of the global population are to be met. The recommendations of Critical Role of Animal Science Research in Food Security and Sustainability will inform a new roadmap for animal science research to meet the challenges of sustainable animal production in the 21st century.
Author: Food and Agriculture Organization of the United Nations Publisher: Food & Agriculture Org. ISBN: 9251343403 Category : Science Languages : en Pages : 156
Book Description
Aquaculture sector in Asia-Pacific has grown rapidly during the past four decades and contributed significantly to food security, nutrition, livelihood and overall socioeconomic development in the region. Meanwhile, disease problem has become increasingly challenging in aquaculture. Un-prudent and poorly controlled use of anti-microbial in animal disease control in aquaculture can have significant contribution to AMR risk. Although the control over the use of antimicrobial in aquaculture through some regulatory frameworks has been strengthened over the past decade in the region, it is far from adequate and effective in many Asian countries. In order to support the members to effectively address AMR in aquaculture for public health and sustainability of the sector, FAO and Network of Aquaculture Centres in Asia-Pacific (NACA) jointly organized the regional consultation on AMR associated with aquaculture in Asia-Pacific on 4-6 September 2018. This publication documents the conduct of the regional consultation and its outputs, which identified major issues and gaps in tackling AMR issue in aquaculture and recommended desirable interventions and long-term strategy to effective mitigate AMR risk related to aquaculture in the region. The document also includes the seven country case studies on status of use of antimicrobial in aquaculture and the efforts to manage the risks of antimicrobial resistance, which were presented at the regional consultation.
Author: Gilberto Igrejas
Author: Gilberto Igrejas
Author: Gilberto Igrejas
Author: 
Author: Donna U. Vogt
Author: Isabelle Pailliart
Author: Institute of Medicine
Author: National Academies of Sciences, Engineering, and Medicine
Author: King K. Holmes
Author: National Research Council
Author: Food and Agriculture Organization of the United Nations