Author: Juan Luis Vivero-EscotoPublisher:
ISBN:
Category :
Languages : en
Pages : 162
Book Description
Surface Functionalized Mesoporous Silica Nanoparticles for Intracellular Drug Delivery
Author: Juan Luis Vivero-EscotoPublisher:
ISBN:
Category :
Languages : en
Pages : 162
Book Description
Development and Application of Multi-functionalized Mesoporous Silica Nanomaterials in Intracellular Drug Delivery and Heterogeneous Catalysis
Author: Chih-Hsiang TsaiMesoporous Materials for Drug Delivery and Theranostics
Author: Valentina CaudaPublisher: MDPI
ISBN: 3039439391
Category : Science
Languages : en
Pages : 204
Book Description
Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Functionalized Mesoporous Silica Nanoparticles for Stimuli-responsive and Targeted Drug Delivery
Author: Nikola KneževićFunctionalized Mesoporous Silica Nanoparticles (MSNs) for Applications in Drug Delivery and Catalysis
Author: Wei HuangFunctionalized mesoporous silica nanoparticles for stimuli-responsive and targeted drug delivery
Author: Nikola KnezevicMesoporous Silica Nanoparticles
Author: Sachin Namdeo KothawadePublisher:
ISBN: 9783111338446
Category : Medical
Languages : en
Pages : 0
Book Description
Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.
FASTtrack Pharmaceutics
Author: Yvonne PerriePublisher: Pharmaceutical Press
ISBN: 0857110594
Category : Medical
Languages : en
Pages : 257
Book Description
"Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.
Light and Nanoparticle-based Approaches to the Control of Ion Channels and Drug Delivery
Author: Sébastien FebvayPublisher:
ISBN:
Category :
Languages : en
Pages : 138
Book Description
Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. In the first part of this work, we present a drug delivery method based on light-activated disruption of intracellular vesicles after internalization of bio-functionalized mesoporous silica nanoparticles loaded with cargo. We developed an improved synthesis method to optimize size control of mesoporous silica nanoparticles in the 20-200nm range while preserving porosity. We optimized surface bio-functionalization to obtain a highly stable and targetable nanocarrier, and used an embedded photosensitizer to combine the power of targeted delivery with the spatiotemporal control of light activation. NP-mediated endosomal disruption can be controlled at the single vesicle level. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population. The second part of this thesis investigated the use of both photosensitizer-coupled and magnetic nanoparticles as actuators of ion channels. While direct magnetic actuation was not found to promote activation of the receptors tested, several members of the transient receptor potential superfamily (TRP), notably TRPV3 and TRPA1, were found to be activatable by light in conjunction with photosensitizers, including the endogenously present all-trans retinal. The findings were established using a combination of calcium imaging with both chemical and genetically encoded indicators, in addition to whole cell patch clamping. Spontaneous activation of channels in heterologous expression systems was observed upon illumination at selective wavelengths, establishing an effective actuation method, potentially adding native channels to the current opto-genetic toolbox.
Microbial Interactions at Nanobiotechnology Interfaces
Author: R. Navanietha KrishnarajPublisher: John Wiley & Sons
ISBN: 1119617197
Category : Technology & Engineering
Languages : en
Pages : 420
Book Description
MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.