OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay PDF Download

Author: OECD
Publisher: OECD Publishing
ISBN: 9264076247
Category :
Languages : en
Pages : 33

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This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...

Author: Yun-Bo Shi
Publisher: Wiley-Liss
ISBN: 9780471244752
Category : Science
Languages : en
Pages : 292

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Book Description
In an age when advanced molecular and genetic tools allow studies in various systems, amphibian metamorphosis still offers perhaps the most accessible model for the study of postembryonic organogenesis and mechanisms of hormonal regulation during vertebrate development. Amphibian Metamorphosis: From Morphology to Molecular Biology integrates findings from the most recent research with earlier observations, providing molecular and mechanistic insights into the signal transduction pathways underlying tissue-specific transformations during metamorphosis. The author, renowned expert of anuran metamorphosis and Head of the Unit of Molecular Morphogenesis at NICHD/NIH, begins with an overview of metamorphosis in different classes of amphibians and various factors that influence this process. A review of earlier morphological, cellular, and biochemical changes focuses on organs and tissues that have been studied extensively at the molecular level, while discussion of the thyroid hormone signal transduction pathway emphasizes transcriptional regulation mechanisms by thyroid receptors. The book provides a summary and comparison of gene regulation programs induced by thyroid hormone in several organs that undergo distinct metamorphic transformations. Several chapters are devoted to functional and mechanistic implications of the molecular findings on the thyroid hormone response genes in tissue transformation. Special features of this book include: * An emphasis on integrating the morphological approach with molecularand cell biology * A historical perspective on the progression from discovery of the thyroid hormone to present-day research advances * Comparisons of amphibian and insect metamorphosis * Dozens of instructive photographs, several in full color Amphibian Metamorphosis: From Morphology to Molecular Biology is a unique and invaluable resource for professionals and aspiring professionals in develop-mental biology, molecular biology, cell biology, evolutionary biology, and endocrinology.

Author: Maria Oielska
Publisher: CRC Press
ISBN: 1482280132
Category : Nature
Languages : en
Pages : 437

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This book deals with reproduction of Amphibians belonging to three extant orders: Caecilians, Salamanders, Frogs and Toads. Separate chapters have been written for males and females; the chapters describe gonad structure and development, gametogenesis, urogenital connections, and reproductive tracts. The authors have provided a synthesis of the lit

Author: David O. Norris
Publisher: Springer Science & Business Media
ISBN: 1461318696
Category : Science
Languages : en
Pages : 627

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Comparative endocrinology is one of the most rapidly developing subdis ciplines within the field of endocrinology, and it is having a significant impact on research at the molecular, cellular, organisma1 and environmental levels. Much of the current ferment in endocrinology is in reproductive endocrinology. The purpose of this volume on hormones and reproduction in fishes, amphibians and reptiles is to summarize our present understandings and to identify important research problems to be addressed in the area of comparative reproductive endocrinology. It was inspired by the gathering at Copper Mountain, Colorado, of eminent endocrine scientists from around the world on the occasion of the Tenth International Symposium on Comparative Endocrinology in July, 1985. While preparing for that meeting, we decided that a special volume on reproductive endocrinology was needed to summarize what is known and to stimulate research in particular directions. Why do we emphasize fishes, amphibians and reptiles? First, knowledge about the reproductive endocrinology of these ectothermic vertebrates can provide a clearer picture of the evolution of reproductive hormones and their effects on target organs. This comparative approach can lead to new theories about the evolution of reproductive control mechanisms. Second, studies concerning the reproductive endocrinology of "lower" vertebrates can result in development of "model systems" for application to studies of birds and mammals. Indeed, information about the patterns of reproductive control in ectothermic vertebrates can tell us which are evolutionarily stable and which are labile.

Author:
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 1776

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309064198
Category : Science
Languages : en
Pages : 453

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Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Author: Pierre Comizzoli
Publisher: Springer Nature
ISBN: 3030236331
Category : Science
Languages : en
Pages : 558

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This second edition emphasizes the environmental impact on reproduction, with updated chapters throughout as well as complete new chapters on species such as sharks and rays. This is a wide-ranging book that will be of relevance to anyone involved in species conservation, and provides critical perspectives on the real utility of current and emerging reproductive sciences. Understanding reproductive biology is centrally important to the way many of the world’s conservation problems should be tackled. Currently the extinction problem is huge, with up to 30% of the world’s fauna being expected to disappear in the next 50 years. Nevertheless, it has been estimated that the global population of animals in zoos encompasses 12,000 – 15,000 species, and we anticipate that every effort will be made to preserve these species for as long as possible, minimizing inbreeding effects and providing the best welfare standards available. Even if the reproductive biology community cannot solve the global biodiversity crisis for all wild species, we should do our best to maintain important captive populations. Reproductive biology in this context is much more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species that society might target for a variety of reasons, whether nationalistic, cultural or practical, technical developments have to be backed up by thorough biological understanding of the background behind the problems.

Author:
Publisher: Academic Press
ISBN: 0080536352
Category : Science
Languages : en
Pages : 705

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Book Description
Metamorphosis addresses various facets of postembryonic development, particularly signal transduction, morphogenesis, cell-cell interactions, and programmed cell death. A key feature of the book is its exploration of the molecular mechanisms underlying these processes. - Hormonal regulation of development - The mechanisms of hormone action - The steroid/thyroid hormone receptor family - Morphogenesis and programmed cell death

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 826

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Author: P.S.Verma
Publisher: S. Chand Publishing
ISBN: 8121916399
Category : Science
Languages : en
Pages : 1095

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FOR B.Sc & B.Sc.(Hons) CLASSES OF ALL INDIAN UNIVERSITIES AND ALSO AS PER UGC MODEL CURRICULUMN Contents: CONTENTS:Protochordates:Hemicholrdata 1.Urochordata Cephalochordata Vertebrates : Cyclostomata 3. Agnatha, Pisces Amphibia 4. Reptilia 5. Aves Mammalia 7 Comparative Anatomy:lntegumentary System 8 Skeletal System Coelom and Digestive System 10 Respiratory System 11. Circulatory System Nervous System 13. Receptor Organs 14 Endocrine System 15 Urinogenital System 16 Embryology Some Comparative Charts of Protochordates 17 Some Comparative Charts of Vertebrate Animal Types 18 Index.