Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Time-of-flight Mass Spectrometry PDF full book. Access full book title Time-of-flight Mass Spectrometry by Robert J. Cotter. Download full books in PDF and EPUB format.
Author: Robert J. Cotter Publisher: ISBN: Category : Science Languages : en Pages : 360
Book Description
This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.
Author: Imma Ferrer Publisher: John Wiley & Sons ISBN: 047042995X Category : Science Languages : en Pages : 281
Book Description
Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants—such as antibiotics, steroids, analgesics—using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.
Author: Robert J. Cotter Publisher: ISBN: Category : Science Languages : en Pages : 360
Book Description
This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.
Author: Edward William Schlag Publisher: Elsevier Science & Technology ISBN: Category : Science Languages : en Pages : 432
Book Description
The resurgence of time-of-flight mass spectrometry (TOF-MS) has had its origin in the simplicity of construction and application of such instruments together with the high transmission and the great increase in resolution that has been achieved. The instrument lends itself naturally to a coupling with pulsed laser sources, though this is not a prerequisite. It also affords a time resolution far beyond that traditionally achieved with mass spectrometric rapid scan techniques - a recent example being the real-time analysis of a multi-component mixture from an automobile exhaust. Furthermore, the mass range appears to be extremely large: mass up to 500 kDa and beyond what is being readily measured in the laboratory today.The present set of contributions attempts to give a survey of current applications from many of the active groups in the field. A variety of new applications are considered which are no doubt just the beginning of large new areas of application. By presenting this work in book form it is hoped that it will be of help to the many groups intending to initiate work in this rapidly expanding new area of mass spectrometry.
Author: Sarah Fearn Publisher: Morgan & Claypool Publishers ISBN: 1681740885 Category : Technology & Engineering Languages : en Pages : 67
Book Description
This book highlights the application of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) for high-resolution surface analysis and characterization of materials. While providing a brief overview of the principles of SIMS, it also provides examples of how dual-beam ToF-SIMS is used to investigate a range of materials systems and properties. Over the years, SIMS instrumentation has dramatically changed since the earliest secondary ion mass spectrometers were first developed. Instruments were once dedicated to either the depth profiling of materials using high-ion-beam currents to analyse near surface to bulk regions of materials (dynamic SIMS), or time-of-flight instruments that produced complex mass spectra of the very outer-most surface of samples, using very low-beam currents (static SIMS). Now, with the development of dual-beam instruments these two very distinct fields now overlap.
Author: D. Price Publisher: Elsevier ISBN: 1483151190 Category : Science Languages : en Pages : 313
Book Description
Time-of-Flight Mass Spectrometry contains the proceedings of the First European Symposium on Time-of-flight Mass Spectrometry held at the University of Salford in the UK on July 3-5, 1967. The papers focus on time-of-flight mass spectrometry and its chemical applications, from flash photolysis and pyrolysis reactions to shock wave reactions and high-temperature studies of inorganic solids. This book is comprised of nine chapters and opens with an introduction to the MA-1 and other time-of-flight mass spectrometers, followed by their applications to studies of chemical reactions such as flash photolysis and pyrolysis reactions, reactions involving shock waves, and high-temperature studies of inorganic solids. Subsequent chapters explore fast recording techniques for time-resolved mass spectrometry; detection of the NH2 free radical and other ammoniacal complexes in the electrical discharge decomposition of ammonia gas; and reactions of ions with molecules in the gas phase and the sputtering of solid surfaces by ion bombardment. The use of a time-of-flight mass spectrometer in experimental investigations of negative ions is also described. This monograph will be a valuable resource for users of a time-of-flight mass spectrometer and allow non-users to become acquainted with its applications and advantages.
Author: Harald Pasch Publisher: Springer Science & Business Media ISBN: 3662050463 Category : Science Languages : en Pages : 312
Book Description
MALDI-TOF mass spectrometry is one of the latest and most fascinating new developments in the analysis of organic compounds. Originally developed for the analysis of biomolecules, it has developed into one of the most powerful techniques for the characterization of synthetic polymers. This book describes the fundamentals of the MALDI process and the technical features of MALDI-TOF instrumentation. It reviews the application of MALDI-TOF for identification, chemical and molar mass analysis of synthetic polymers. With many examples, the monograph examines experimental protocols for the determination of endgroups, the analysis of copolymers and additives, and the coupling of liquid chromatography and MALDI-TOF in detail.
Author: Charles L. Wilkins Publisher: CRC Press ISBN: 1439813256 Category : House & Home Languages : en Pages : 374
Book Description
The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved w
Author: Charlotte H. Clarke Publisher: Humana Press ISBN: 9781617794179 Category : Science Languages : en Pages : 239
Book Description
SELDI is distinct from other TOF-MS technologies in that it couples features of chromatography and mass spectrometry, facilitating analyte enrichment and sample cleanup on an array surface. In the growing field of proteomics, SELDI technology has been widely used for biomarker discovery and characterization in diverse applications including diagnostics, drug development, and basic research. SELDI-based biomarker studies can typically be divided into four phases: discovery, validation, purification and identification, and assay development. SELDI-TOF Mass Spectrometry: Methods and Protocols provides an overview of the current applications of SELDI-TOF MS (surface enhanced laser desorption/ionization time-of-flight mass spectrometry), with an emphasis on study and experimental design, data analysis and interpretation, and assay development. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, SELDI-TOF Mass Spectrometry: Methods and Protocols will provide information on optimizing study design, experimental protocols, and data analysis and interpretation to yield robust biomarkers and biomarker assays, using examples from different disease areas.
Author: Robert J. Cotter
Author: Imma Ferrer
Author: Robert J. Cotter
Author: Edward William Schlag
Author: Sarah Fearn
Author: John David Pinkston
Author: R. J. Lewis
Author: D. Price
Author: Harald Pasch
Author: Charles L. Wilkins
Author: Charlotte H. Clarke