Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis PDF Download

Author: Teresa Torres
Publisher: Product Talk LLC
ISBN: 1736633317
Category : Design
Languages : en
Pages : 201

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Book Description
"If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

Author: Peter T. Hoffman
Publisher: Aspen Publishing
ISBN: 1601564368
Category : Law
Languages : en
Pages : 412

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Book Description
Effective Discovery: Techniques and Strategies That Work is a comprehensive practical guide to "paper" discovery and related undertakings—discovery conferences, plans, reports, and orders; disclosures; interrogatories; requests for production; physical and mental exams; requests for admission; electronic discovery; motions; and subpoenas. This informative and eminently readable text takes litigators through the stages of discovery, addressing: discover objectives, planning, strategies, ethics, and rules; when and how to use discovery devices alone and in combination; how to assess which discovery devices will work best in your circumstances; how to draft discovery designed to get needed information; how to respond when the other side is evading—or refusing—your discovery; proportionality—assessing when enough is enough, too much, or not nearly enough; what judges want and don’t want—and the Laws of Unintended Consequences and What Goes Around, Comes Around. The book is a companion to NITA’s best-selling The Effective Deposition. Together, the two volumes provide an in-depth guide to discovery in all its forms.

Author:
Publisher: World Health Organization
ISBN: 9240026436
Category : Medical
Languages : en
Pages : 88

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Book Description

Author: Rich Horwath
Publisher: Greenleaf Book Group
ISBN: 1608322521
Category : Business & Economics
Languages : en
Pages : 151

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Book Description
Most people have spent their lives randomly bouncing around like bumper cars, never arriving at the life they want. If fact, new research shows that only 15 percent of adults have a plan for their life. But what if there was a way, a proven way, to experience more of what life has to offer?In "Strategy for You," world-renowned strategist Rich Horwath provides a proven plan for building the bridge to an exceptional life. Based on Horwath's ground-breaking work in the field of strategic thinking, the book helps readers apply the time-tested principles of business strategy to their lives. The author incorporates GOST (goals, objectives, strategies, tactics_, SWOT (strengths, weaknesses, opportunities, threats), and other business tools into a five-step plan that enables readers toDISCOVER the purpose in their lives

Author: Manoj C. Desai
Publisher: Royal Society of Chemistry
ISBN: 1849737819
Category : Science
Languages : en
Pages : 544

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Book Description
The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Author: Stefania Mondello
Publisher: Frontiers Media SA
ISBN: 2889193918
Category : Biochemical markers
Languages : en
Pages : 179

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Book Description
Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

Author: David J Hand
Publisher: Springer
ISBN: 3540457283
Category : Computers
Languages : en
Pages : 239

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Book Description
The collation of large electronic databases of scienti?c and commercial infor- tion has led to a dramatic growth of interest in methods for discovering struc- res in such databases. These methods often go under the general name of data mining. One important subdiscipline within data mining is concerned with the identi?cation and detection of anomalous, interesting, unusual, or valuable - cords or groups of records, which we call patterns. Familiar examples are the detection of fraud in credit-card transactions, of particular coincident purchases in supermarket transactions, of important nucleotide sequences in gene sequence analysis, and of characteristic traces in EEG records. Tools for the detection of such patterns have been developed within the data mining community, but also within other research communities, typically without an awareness that the - sic problem was common to many disciplines. This is not unreasonable: each of these disciplines has a large literature of its own, and a literature which is growing rapidly. Keeping up with any one of these is di?cult enough, let alone keeping up with others as well, which may in any case be couched in an - familiar technical language. But, of course, this means that opportunities are being lost, discoveries relating to the common problem made in one area are not transferred to the other area, and breakthroughs and problem solutions are being rediscovered, or not discovered for a long time, meaning that e?ort is being wasted and opportunities may be lost.

Author: Mike S. Lee
Publisher: John Wiley & Sons
ISBN: 0471721026
Category : Science
Languages : en
Pages : 576

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Book Description
New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Author: S. Cyrus Khojasteh
Publisher: Springer Nature
ISBN: 3031106911
Category : Medical
Languages : en
Pages : 241

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Book Description
This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.

Author: Ana Fred
Publisher: Springer
ISBN: 3642371868
Category : Computers
Languages : en
Pages : 481

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Book Description
This book constitutes the thoroughly refereed post-conference proceedings of the Third International Joint Conference on Knowledge Discovery, Knowledge Engineering, and Knowledge Management, IC3K 2011, held in Paris, France, in October 2011. This book includes revised and extended versions of a strict selection of the best papers presented at the conference; 39 revised full papers together with one invited lecture were carefully reviewed and selected from 429 submissions. According to the three covered conferences KDIR 2011, KEOD 2011, and KMIS 2011, the papers are organized in topical sections on knowledge discovery and information retrieval, knowledge engineering and ontology development, and on knowledge management and information sharing.