Stochastic Cellular Systems PDF Download

Author: R. L. Dobrushin
Publisher: Manchester University Press
ISBN: 9780719022067
Category : Cellular automata
Languages : en
Pages : 568

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Author: Paul C. Bressloff
Publisher: Springer Nature
ISBN: 3030725154
Category : Mathematics
Languages : en
Pages : 773

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Book Description
This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Author: Frederik Graw
Publisher: Springer
ISBN: 3319458337
Category : Technology & Engineering
Languages : en
Pages : 167

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Book Description
This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.

Author: Marianne Stefanini
Publisher:
ISBN:
Category : Biological systems
Languages : en
Pages : 324

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Author: Mukhtar Ullah
Publisher: Springer Science & Business Media
ISBN: 1461404789
Category : Mathematics
Languages : en
Pages : 319

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Book Description
This textbook focuses on stochastic analysis in systems biology containing both the theory and application. While the authors provide a review of probability and random variables, subsequent notions of biochemical reaction systems and the relevant concepts of probability theory are introduced side by side. This leads to an intuitive and easy-to-follow presentation of stochastic framework for modeling subcellular biochemical systems. In particular, the authors make an effort to show how the notion of propensity, the chemical master equation and the stochastic simulation algorithm arise as consequences of the Markov property. The text contains many illustrations, examples and exercises to illustrate the ideas and methods that are introduced. Matlab code is also provided where appropriate. Additionally, the cell cycle is introduced as a more complex case study. Senior undergraduate and graduate students in mathematics and physics as well as researchers working in the area of systems biology, bioinformatics and related areas will find this text useful.

Author: Hong Qian
Publisher: Springer Nature
ISBN: 3030862526
Category : Mathematics
Languages : en
Pages : 364

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Book Description
This book provides an introduction to the analysis of stochastic dynamic models in biology and medicine. The main aim is to offer a coherent set of probabilistic techniques and mathematical tools which can be used for the simulation and analysis of various biological phenomena. These tools are illustrated on a number of examples. For each example, the biological background is described, and mathematical models are developed following a unified set of principles. These models are then analyzed and, finally, the biological implications of the mathematical results are interpreted. The biological topics covered include gene expression, biochemistry, cellular regulation, and cancer biology. The book will be accessible to graduate students who have a strong background in differential equations, the theory of nonlinear dynamical systems, Markovian stochastic processes, and both discrete and continuous state spaces, and who are familiar with the basic concepts of probability theory.

Author: Martin Haenggi
Publisher: Cambridge University Press
ISBN: 1107014697
Category : Computers
Languages : en
Pages : 301

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Book Description
Analyse wireless network performance and improve design choices for future architectures and protocols with this rigorous introduction to stochastic geometry.

Author: David Holcman
Publisher: Springer
ISBN: 3319626272
Category : Mathematics
Languages : en
Pages : 377

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Book Description
This book focuses on the modeling and mathematical analysis of stochastic dynamical systems along with their simulations. The collected chapters will review fundamental and current topics and approaches to dynamical systems in cellular biology. This text aims to develop improved mathematical and computational methods with which to study biological processes. At the scale of a single cell, stochasticity becomes important due to low copy numbers of biological molecules, such as mRNA and proteins that take part in biochemical reactions driving cellular processes. When trying to describe such biological processes, the traditional deterministic models are often inadequate, precisely because of these low copy numbers. This book presents stochastic models, which are necessary to account for small particle numbers and extrinsic noise sources. The complexity of these models depend upon whether the biochemical reactions are diffusion-limited or reaction-limited. In the former case, one needs to adopt the framework of stochastic reaction-diffusion models, while in the latter, one can describe the processes by adopting the framework of Markov jump processes and stochastic differential equations. Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology will appeal to graduate students and researchers in the fields of applied mathematics, biophysics, and cellular biology.

Author: Bartłomiej Błaszczyszyn
Publisher: Cambridge University Press
ISBN: 1107162580
Category : Mathematics
Languages : en
Pages : 207

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Book Description
Achieve faster and more efficient network design and optimization with this comprehensive guide. Some of the most prominent researchers in the field explain the very latest analytic techniques and results from stochastic geometry for modelling the signal-to-interference-plus-noise ratio (SINR) distribution in heterogeneous cellular networks. This book will help readers to understand the effects of combining different system deployment parameters on key performance indicators such as coverage and capacity, enabling the efficient allocation of simulation resources. In addition to covering results for network models based on the Poisson point process, this book presents recent results for when non-Poisson base station configurations appear Poisson, due to random propagation effects such as fading and shadowing, as well as non-Poisson models for base station configurations, with a focus on determinantal point processes and tractable approximation methods. Theoretical results are illustrated with practical Long-Term Evolution (LTE) applications and compared with real-world deployment results.

Author: Armin Zimmermann
Publisher: Springer Science & Business Media
ISBN: 3540741739
Category : Computers
Languages : en
Pages : 393

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Book Description
Stochastic discrete-event systems (SDES) capture the randomness in choices due to activity delays and the probabilities of decisions. This book delivers a comprehensive overview on modeling with a quantitative evaluation of SDES. It presents an abstract model class for SDES as a pivotal unifying result and details important model classes. The book also includes nontrivial examples to explain real-world applications of SDES.