Stereoselectivity in Modern-use Chiral Pesticides PDF Download

Author: Mae Grace Gareza Nillos, 1974-
Publisher:
ISBN:
Category : Chirality
Languages : en
Pages : 434

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Author: Everhardus Jacobus Ariëns
Publisher: Elsevier Publishing Company
ISBN:
Category : Technology & Engineering
Languages : en
Pages : 564

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Book Description
Recently there has been growing concern about the hazards for man and his environment due to exposure to chemicals. One aspect receiving particular attention is that of the neglect of stereoselectivity in bioactive agents such as pesticides, drugs, etc. Mixtures of stereoisomers often contain 50 percent inactive material in the form of isomeric ballast. This ballast is pure environmental pollutant. Decisions as to whether the use of mixtures of stereoisomers is acceptable are only possible and acceptable if they are based on sound scientific information. It is the purpose of this volume to contribute to, and to disseminate, knowledge in this field. Written for workers in the field of pesticides, the book contains concise and basic information on stereoselectivity as a notable source of problems. Attention is paid to the involvement of stereoselectivity in important classes of pesticides as well as to pheromones and compounds derived from insect hormones with potential use in crop protection. Fundamentals of stereochemistry, stereoselective analytical methods, stereoselective synthesis and stereochemical aspects of the design of new compounds are also discussed.

Author: A. Wayne Garrison
Publisher: OUP USA
ISBN: 9780841226791
Category : Science
Languages : en
Pages : 0

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An examination of chirality as an environmental phenomenon

Author: Erick M. Carreira
Publisher: John Wiley & Sons
ISBN: 9783527324521
Category : Science
Languages : en
Pages : 664

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Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.

Author: Robert S. Atkinson
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 552

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Introduces a new classification for stereoselective reactions based on the number of chiral centres contained in the starting material and the product. Based on stereochemical terms, this classification enables users to apply methods for the synthesis of target molecules.

Author: Hassan Y. Aboul-Enein
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 736

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Book Description
The past fifteen years have seen a revolution in the field of stereochemistry, with breakthrough analytical techniques in enantiomeric separation profoundly affecting drug development and use. This practical reference written by leading researchers focuses on the important roles chirality and stereoisomerism play in drug development efforts--presenting for the first time a comprehensive overview of this rapidly evolving area of pharmacological research. The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops. The introductory chapters outline the pharmacological effects of stereochemistry, cover stereochemistry in drug metabolism, and discuss problems inherent in the duality of enantiomers--chemically identical yet spatially different molecules. Contributions on the specific aspects of chirality and drug activity explore the toxicological effects of stereoselectivity, illustrate how an understanding of the stereochemical composition of certain drugs can help avoid problems, and offer tips on new clinical applications for existing drugs. A full chapter is devoted to research opportunities in the development of new chirally pure drugs. Other practical research topics range from the preparation of chirally pure compounds to the analytical determination of stereochemical composition, to applications of circular dichroism (CD) spectroscopy. Regulatory issues concerning the development and approval of stereoisomeric drugs are discussed in the final chapters. This section offers an international perspective as well as a historical review of the ongoing debate surrounding regulatory guidelines. Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field. Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field. IMPACT OF STEREOCHEMISTRY ON DRUG DEVELOPMENT AND USE Twenty-three expert contributions on the "stereochemical revolution" of the last fifteen years--covering analytical, pharmacological, and regulatory topics--show that "drug development can no longer occur without consideration of drug stereochemistry." "We have...come full circle and stand alongside Pasteur in amazement of nature's duality, symmetry and dissymmetry, and its chemical and pharmacological consequences."--from the Preface

Author: Indra K. Reddy
Publisher: CRC Press
ISBN: 0824751094
Category : Science
Languages : en
Pages : 406

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Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Author: Norio Kurihara
Publisher: John Wiley & Sons
ISBN: 0471981214
Category : Technology & Engineering
Languages : en
Pages : 292

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Book Description
Bisher gab es kein Buch, das sich speziell mit der Chiralität von Agrochemikalien beschäftigte, obwohl dieses Gebiet zunehmende Beachtung in der Industrie findet. Diese Darstellung der Chiralität bei Insektiziden, Fungiziden, Herbiziden und anderen Klassen von Agrochemikalien schließt diese Lücke. Synthese, Analytik, biologische Aktivität, Wirkprinzip, Toxikologie, Metabolismus und Umweltschicksal jeder besprochenen Verbindung werden diskutiert. (8/98)

Author: Edmond Sanganyado
Publisher: CRC Press
ISBN: 1000298884
Category : Science
Languages : en
Pages : 397

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Book Description
Chiral Organic Pollutants introduces readers to the growing challenges of chirality in synthetic chemicals. In this volume, contributors brilliantly summarize the characteristics of chiral pollutants to provide tools and techniques for effectively assessing their environmental and human health risks. Chapters cover recent research on the physicochemical properties, sources, exposure pathways, environmental fate, toxicity, and enantioselective analysis of chiral organic pollutants. Chiral Organic Pollutants also provides comprehensive discussions on the current trends in the synthesis and legislation of chiral chemicals. Key Features: Includes sampling and analytical methods for the enantioselective analysis of a wide array of chiral organic pollutants in food and the environment Summarizes recent research on the sources, fate, transport, and toxicity of chiral organic pollutants in the environment Critically examines the sources and pathways of chiral organic pollutants such as pesticides, pharmaceuticals, and flame retardants in food Includes a comprehensive discussion on current trends in the enantioselective synthesis and chiral switching of pesticides and pharmaceuticals Provides analysis of current national and international regulations of chiral synthetic chemicals The use of chiral synthetic chemicals such as pesticides, pharmaceuticals, personal care products, and halogenated flame retardants has significantly grown in the past 60 years. Hence, understanding the human and environmental health effects of chiral organic pollutants is crucial in the industry, academia, and policymaking. Chiral Organic Pollutants is an excellent textbook and reference for students, scientists, engineers, and policymakers interested in food quality, environmental pollution, chemical analysis, organic synthesis, and toxicology. Also available in the Food Analysis and Properties Series: Analysis of Nanoplastics and Microplastics in Food, edited by Leo. M.L. Nollet and Khwaja Salahuddin Siddiqi (ISBN: 9781138600188) Proteomics for Food Authentication, edited by Leo M.L. Nollet, and Semih Ötleş (ISBN: 9780367205058) Mass Spectrometry Imaging in Food Analysis, edited by Leo M.L. Nollet (ISBN: 9781138370692) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

Author: Ernest L. Eliel
Publisher: Wiley-Interscience
ISBN:
Category : Science
Languages : en
Pages : 712

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Book Description
A Practical Introduction to Stereochemistry Stereoisomers are compounds with the same chemical formula and connectivity but with different arrangements of their atoms in 3-dimensional space. Stereochemistry encompasses the study of stereoisomers and their properties. Despite having an identical chemical formula, stereoisomers can have drastically different biological, medicinal, and chemical properties. Basic Organic Stereochemistry explains in clear, concise terms the concepts and properties of stereoisomers. Ideal both as a text for advanced undergraduate or graduate students and as a handy guide for researchers in industry, this superb text covers: * Polarimetry and optical rotation * Internal coordinates, configuration, and conformation * Nature of stereoisomers * Barriers between stereoisomers and residual stereoisomers * Symmetry operators and symmetry point groups * Properties of stereoisomers and stereoisomer discrimination * Separation of stereoisomers, resolution, and racemization Suitable for students in organic and biological chemistry, Basic Organic Stereochemistry is unparalleled as a convenient text.