The Analysis of Case-control Studies PDF Download

Author: Norman E. Breslow
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 352

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Author: Norman E. Breslow
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 440

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Author: Ole Møller Jensen
Publisher: IARC
ISBN: 9283211952
Category : Medical
Languages : en
Pages : 295

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Book Description
Data obtained by population based cancer registries have a pivotal role in cancer control. Now also available in Spanish and French, this volume, which contains 15 authored chapters and four useful appendices, remains a standard reference for those planning to establish new cancer registries and those keen to adopt recognized methodologies. Information is given on the techniques required to collect, store, analyse and interpret data.

Author: Isabel dos Santos Silva
Publisher: IARC
ISBN: 9789283204053
Category : Medical
Languages : en
Pages : 466

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Book Description
A basic textbook addressed to medical and public health students, clinicians, health professionals, and all others seeking to understand the principles and methods used in cancer epidemiology. Written by a prominent epidemiologist and experienced teacher at the London School of Hygiene and Tropical Medicine, the text aims to help readers become competent in the use of basic epidemiological tools and capable of exercising critical judgment when assessing results reported by others. Throughout the text, a lively writing style and numerous illustrative examples, often using real research data, facilitate an easy understanding of basic concepts and methods. Information ranges from an entertaining account of the origins of epidemiology, through advice on how to overcome some of the limitations of survival analysis, to a checklist of questions to ask when considering sources of bias. Although statistical concepts and formulae are presented, the emphasis is consistently on the interpretation of the data rather than on the actual calculations. The text has 18 chapters. The first six introduce the basic principles of epidemiology and statistics. Chapters 7-13 deal in more depth with each of the study designs and interpretation of their findings. Two chapters, concerned with the problems of confounding and study size, cover more complex statistical concepts and are included for advanced study. A chapter on methodological issues in cancer prevention gives examples of epidemiology's contribution to primary prevention, screening and other activities for early detection, and tertiary prevention. The concluding chapters review the role of cancer registries and discuss practical considerations that should be taken into account in the design, planning, and conduct of any type of epidemiological research.

Author: Xiaochun Li
Publisher: Springer Science & Business Media
ISBN: 0387697659
Category : Medical
Languages : en
Pages : 164

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Book Description
Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

Author: John D. Kalbfleisch
Publisher: John Wiley & Sons
ISBN: 1118031237
Category : Mathematics
Languages : en
Pages : 462

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Book Description
Contains additional discussion and examples on left truncationas well as material on more general censoring and truncationpatterns. Introduces the martingale and counting process formulation swillbe in a new chapter. Develops multivariate failure time data in a separate chapterand extends the material on Markov and semi Markovformulations. Presents new examples and applications of data analysis.

Author: Edward L. Korn
Publisher: John Wiley & Sons
ISBN: 1118030869
Category : Mathematics
Languages : en
Pages : 408

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Book Description
How to apply statistical methods to survey data--a guide toeffective analysis of health surveys. With large health surveys becoming increasingly available forpublic use, researchers with little experience in survey methodsare often faced with analyzing data from surveys to addressscientific and programmatic questions. This practical book providesstatistical techniques for use in survey analysis, making healthsurveys accessible to statisticians, biostatisticians,epidemiologists, and health researchers. The authors clearlyexplain the theory and methods of survey analysis along withreal-world applications. They draw on their work at the NationalInstitutes of Health as well as up-to-date information from acrossthe literature to present: * The sampling background necessary to understand health surveys. * The application of such techniques as t-tests, linear regression,logistic regression, and survival analysis to survey data. * The use of sample weights in survey data analysis. * Dealing with complications in variance estimation in large healthsurveys. * Applications involving cross-sectional, longitudinal, andmultiple cross-sectional surveys, and the use of surveys to performpopulation- based case-control analyses. * Guidance on the correct use of statistical methods found insoftware packages. * Extensive bibliography.

Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 1119429250
Category : Science
Languages : en
Pages : 1740

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Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Author: Barbara Hazard Munro
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781748407
Category : Medical
Languages : en
Pages : 518

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Book Description
Focusing on the statistical methods most frequently used in the health care literature and featuring numerous charts, graphs, and up-to-date examples from the literature, this text provides a thorough foundation for the statistics portion of nursing and all health care research courses. All Fifth Edition chapters include new examples and new computer printouts using the latest software, SPSS for Windows, Version 12. New material on regression diagnostics has been added.

Author: Mitchell Katz
Publisher: Cambridge University Press
ISBN: 1139643738
Category : Medical
Languages : en
Pages : 229

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Book Description
This book takes the reader through the entire research process: choosing a question, designing a study, collecting the data, using univariate, bivariate and multivariable analysis, and publishing the results. It does so by using plain language rather than complex derivations and mathematical formulae. It focuses on the nuts and bolts of performing research by asking and answering the most basic questions about doing research studies. Making good use of numerous tables, graphs and tips, this book helps to demystify the process. A generous number of up-to-date examples from the clinical literature give an illustrated and practical account of how to use multivariable analysis.