Statistical Methods for Dynamic Disease Screening and Spatio-Temporal Disease Surveillance PDF Download

Author: Peihua Qiu
Publisher: CRC Press
ISBN: 1040026729
Category : Mathematics
Languages : en
Pages : 346

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Book Description
Disease screening and disease surveillance (DSDS) constitute two critical areas in public health, each presenting distinctive challenges primarily due to their sequential decision-making nature and complex data structures. Statistical Methods for Dynamic Disease Screening and Spatio-Temporal Disease Surveillance explores numerous recent analytic methodologies that enhance traditional techniques. The author, a prominent researcher specializing in innovative sequential decision-making techniques, demonstrates how these novel methods effectively address the challenges of DSDS. After a concise introduction that lays the groundwork for comprehending the challenges inherent in DSDS, the book delves into fundamental statistical concepts and methods relevant to DSDS. This includes exploration of statistical process control (SPC) charts specifically crafted for sequential decision-making purposes. The subsequent chapters systematically outline recent advancements in dynamic screening system (DySS) methods, fine-tuned for effective disease screening. Additionally, the text covers both traditional and contemporary analytic methods for disease surveillance. It further introduces two recently developed R packages designed for implementing DySS methods and spatio-temporal disease surveillance techniques pioneered by the author's research team. Features • Presents Recent Analytic Methods for DSDS: The book introduces analytic methods for DSDS based on SPC charts. These methods effectively utilize all historical data, accommodating the complex data structure inherent in sequential decision-making processes. • Introduces Recent R Packages: Two recent R packages, DySS and SpTe2M, are introduced. The book not only presents these packages but also demonstrates key DSDS methods using them. • Examines Recent Research Results: The text delves into the latest research findings across various domains, including dynamic disease screening, nonparametric spatio-temporal data modeling and monitoring, and spatio-temporal disease surveillance. • Accessible Description of Methods: Major methods are described in a manner accessible to individuals without advanced knowledge in mathematics and statistics. The goal is to facilitate a clear understanding of ideas and easy implementation. • Real-Data Examples: To aid comprehension, the book provides several real-data examples illustrating key concepts and methods. • Hands-on Exercises: Each chapter includes exercises to encourage hands-on practice, allowing readers to engage directly with the presented methods.

Author: Yinglin Xia
Publisher: CRC Press
ISBN: 1040045669
Category : Mathematics
Languages : en
Pages : 457

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Book Description
This unique book officially defines microbiome statistics as a specific new field of statistics and addresses the statistical analysis of correlation, association, interaction, and composition in microbiome research. It also defines the study of the microbiome as a hypothesis-driven experimental science and describes two microbiome research themes and six unique characteristics of microbiome data, as well as investigating challenges for statistical analysis of microbiome data using the standard statistical methods. This book is useful for researchers of biostatistics, ecology, and data analysts. Presents a thorough overview of statistical methods in microbiome statistics of parametric and nonparametric correlation, association, interaction, and composition adopted from classical statistics and ecology and specifically designed for microbiome research. Performs step-by-step statistical analysis of correlation, association, interaction, and composition in microbiome data. Discusses the issues of statistical analysis of microbiome data: high dimensionality, compositionality, sparsity, overdispersion, zero-inflation, and heterogeneity. Investigates statistical methods on multiple comparisons and multiple hypothesis testing and applications to microbiome data. Introduces a series of exploratory tools to visualize composition and correlation of microbial taxa by barplot, heatmap, and correlation plot. Employs the Kruskal–Wallis rank-sum test to perform model selection for further multi-omics data integration. Offers R code and the datasets from the authors’ real microbiome research and publicly available data for the analysis used. Remarks on the advantages and disadvantages of each of the methods used.

Author: Avery McIntosh
Publisher: CRC Press
ISBN: 1003855962
Category : Mathematics
Languages : en
Pages : 490

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Book Description
Cell and gene therapies have become the third major drug modality in pharmaceutical medicine of the 21st century after low molecular weight and antibody drugs. The gene therapy (GTx) field is rapidly advancing, and yet there are still fundamental scientific questions that remain to be answered. Development of GTx products poses unique challenges and opportunities for drug developers. However, there is lack of a systematic exposition of the GTx product development and the pivotal role of the biostatistician in this process. Development of Gene Therapies: Strategic, Scientific, and Regulatory, and Access Considerations attempts to summarize the current state-of-the-art strategic, scientific, statistical, and regulatory aspects of GTx development. Intended to provide an exposition to the GTx new product development through peer-reviewed papers written by subject matter experts in this emerging field, this book will be useful for researchers in gene therapy drug development, biostatisticians, regulators, patient advocates, graduate students, and the finance and business development community . Key Features: A collection of papers covering a wide spectrum of topics in gene therapies (GTx), written by leading subject matter experts An exposition of the core principles of GTx product development, emerging business models, industry standards, best practices, and regulatory pathways An exposition of statistical and innovative modeling tools for design and analysis of clinical trials of GTx Insights into commercial models, access hurdles, and health economics of gene therapies Case studies of successful GTx approvals from core team members that developed the first two FDA-approved AAV gene therapies: Luxturna and Zolgensma A discussion of potential benefits and hurdles to be overcome for GTx in coming years from a multi-stakeholder perspective

Author: Yixin Fang
Publisher: CRC Press
ISBN: 1040039677
Category : Mathematics
Languages : en
Pages : 246

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Book Description
Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry. Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs

Author: Peihua Qiu
Publisher: CRC Press
ISBN: 1482220415
Category : Business & Economics
Languages : en
Pages : 520

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Book Description
A major tool for quality control and management, statistical process control (SPC) monitors sequential processes, such as production lines and Internet traffic, to ensure that they work stably and satisfactorily. Along with covering traditional methods, Introduction to Statistical Process Control describes many recent SPC methods that improve upon

Author: Peter F. Thall
Publisher: CRC Press
ISBN: 1040026710
Category : Mathematics
Languages : en
Pages : 711

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Book Description
Bayesian Precision Medicine presents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic variables and predictive biomarkers. The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference. A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multistage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer. Features: Describes the connection between causal analysis and statistical inference Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications Presents adaptive methods for clustering similar patient subgroups to improve efficiency Describes Bayesian nonparametric regression analyses of real-world datasets from oncology Provides pointers to software for implementation Bayesian Precision Medicine is primarily aimed at biostatisticians and medical researchers who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.

Author: Hongjie Liu
Publisher: CRC Press
ISBN: 1040086217
Category : Medical
Languages : en
Pages : 486

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Book Description
Association Models in Epidemiology: Study Designs, Modeling Strategies, and Analytic Methods is written by an epidemiologist for graduate students, researchers, and practitioners who will use regression techniques to analyze data. It focuses on association models rather than prediction models. The book targets students and working professionals who lack bona fide modeling experts but are committed to conducting appropriate regression analyses and generating valid findings from their projects. This book aims to offer detailed strategies to guide them in modeling epidemiologic data. Features Custom-Tailored Models: Discover association models specifically designed for epidemiologic study designs. Epidemiologic Principles in Action: Learn how to apply and translate epidemiologic principles into regression modeling techniques. Model Specification Guidance: Get expert guidance on model specifications to estimate exposure-outcome associations, accurately controlling for confounding bias. Accessible Language: Explore regression intricacies in user-friendly language, accompanied by real-world examples that make learning easier. Step-by-Step Approach: Follow a straightforward step-by-step approach to master strategies and procedures for analysis. Rich in Examples: Benefit from 120 examples, 77 figures, 86 tables, and 174 SAS® outputs with annotations to enhance your understanding. Book website located here. Crafted for two primary audiences, this text benefits graduate epidemiology students seeking to understand how epidemiologic principles inform modeling analyses and public health professionals conducting independent analyses in their work. Therefore, this book serves as a textbook in the classroom and as a reference book in the workplace. A wealth of supporting material is available for download from the book’s CRC Press webpage. Upon completing this text, readers should gain confidence in accurately estimating associations between risk factors and outcomes, controlling confounding bias, and assessing effect modification.

Author: Weizhong Yang
Publisher: Academic Press
ISBN: 0128124830
Category : Technology & Engineering
Languages : en
Pages : 390

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Book Description
Early Warning for Infectious Disease Outbreak: Theory and Practice is divided into three parts, with the first section introducing basic theory and key technologies of early warning and the basic principles of infectious disease surveillance. The second section introduces the technical details in the process of establishment, operation and usage of CIDARS and Pudong Syndromic Surveillance and the Early Warning System of the Shanghai World Expo. The third part explores the study of early warning technology, collecting some useful exploration in the fields of infectious diseases involving sentinel setting, data analysis, influence factors study, calculation and evaluation of early warning models. - Provide insights into the theory and practice of early warning systems that have been evaluated and shown to be effective - Presents a synopsis of current state-of-the-art practices and a starting point for the development and evaluation of new methods - Covers applied research and complete case studies that focus on local, regional, national and international implementation - Includes techniques from other fields, such as intelligence and engineering - Explores future innovations in biosurveillance, including advances in analytical methods, modeling and simulation - Addresses policy and organizational issues related to the construction of biosurveillance systems

Author: Peihua Qiu
Publisher: John Wiley & Sons
ISBN: 0471733164
Category : Mathematics
Languages : en
Pages : 344

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Book Description
The first text to bridge the gap between image processing andjump regression analysis Recent statistical tools developed to estimate jump curves andsurfaces have broad applications, specifically in the area of imageprocessing. Often, significant differences in technicalterminologies make communication between the disciplines of imageprocessing and jump regression analysis difficult. Ineasy-to-understand language, Image Processing and JumpRegression Analysis builds a bridge between the worlds ofcomputer graphics and statistics by addressing both the connectionsand the differences between these two disciplines. The authorprovides a systematic analysis of the methodology behindnonparametric jump regression analysis by outlining procedures thatare easy to use, simple to compute, and have proven statisticaltheory behind them. Key topics include: Conventional smoothing procedures Estimation of jump regression curves Estimation of jump location curves of regression surfaces Jump-preserving surface reconstruction based on localsmoothing Edge detection in image processing Edge-preserving image restoration With mathematical proofs kept to a minimum, this book isuniquely accessible to a broad readership. It may be used as aprimary text in nonparametric regression analysis and imageprocessing as well as a reference guide for academicians andindustry professionals focused on image processing or curve/surfaceestimation.

Author: Noel Cressie
Publisher: John Wiley & Sons
ISBN: 1119243041
Category : Mathematics
Languages : en
Pages : 612

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Book Description
Winner of the 2013 DeGroot Prize. A state-of-the-art presentation of spatio-temporal processes, bridging classic ideas with modern hierarchical statistical modeling concepts and the latest computational methods Noel Cressie and Christopher K. Wikle, are also winners of the 2011 PROSE Award in the Mathematics category, for the book “Statistics for Spatio-Temporal Data” (2011), published by John Wiley and Sons. (The PROSE awards, for Professional and Scholarly Excellence, are given by the Association of American Publishers, the national trade association of the US book publishing industry.) Statistics for Spatio-Temporal Data has now been reprinted with small corrections to the text and the bibliography. The overall content and pagination of the new printing remains the same; the difference comes in the form of corrections to typographical errors, editing of incomplete and missing references, and some updated spatio-temporal interpretations. From understanding environmental processes and climate trends to developing new technologies for mapping public-health data and the spread of invasive-species, there is a high demand for statistical analyses of data that take spatial, temporal, and spatio-temporal information into account. Statistics for Spatio-Temporal Data presents a systematic approach to key quantitative techniques that incorporate the latest advances in statistical computing as well as hierarchical, particularly Bayesian, statistical modeling, with an emphasis on dynamical spatio-temporal models. Cressie and Wikle supply a unique presentation that incorporates ideas from the areas of time series and spatial statistics as well as stochastic processes. Beginning with separate treatments of temporal data and spatial data, the book combines these concepts to discuss spatio-temporal statistical methods for understanding complex processes. Topics of coverage include: Exploratory methods for spatio-temporal data, including visualization, spectral analysis, empirical orthogonal function analysis, and LISAs Spatio-temporal covariance functions, spatio-temporal kriging, and time series of spatial processes Development of hierarchical dynamical spatio-temporal models (DSTMs), with discussion of linear and nonlinear DSTMs and computational algorithms for their implementation Quantifying and exploring spatio-temporal variability in scientific applications, including case studies based on real-world environmental data Throughout the book, interesting applications demonstrate the relevance of the presented concepts. Vivid, full-color graphics emphasize the visual nature of the topic, and a related FTP site contains supplementary material. Statistics for Spatio-Temporal Data is an excellent book for a graduate-level course on spatio-temporal statistics. It is also a valuable reference for researchers and practitioners in the fields of applied mathematics, engineering, and the environmental and health sciences.