Author: L. J. Cole
Publisher:
ISBN:
Category : Hematopoietic system
Languages : en
Pages : 24
Book Description
THE CAPACITY OF INTRAVENOUSLY INJECTED CELLS FROM PERITONEAL FLUID, PERIPHERAL BLOOD, LYMPH NODES, THYMUS AND BONE MARROW OF MICE TO RESTORE HEMATOPOIESIS IN LETHALLY X-irradiated (880 rad) isogenic recipients, was investigated. Thirtyday survival, and visible colony formation in the spleen were employed as he criteria. Administration of 6 million or 11 million peritoneal cells, and 6,400,000 or 15 million peripheral leukocytes afforded protection against mortality, and elicited colonies in the spleen; comparable effects were observe after injection of 110,000 marrow cells. The injection of 34 million adult lymph node cells or of 9 million thymus cells from newborn mice had no effect on mortality, nor did they elicit spleen colony formation. A corelation appears to exist between the capacity of isogenic cells to restore hemopoiesis in lethally irradiated mice and their ability to elicit visible colony formation in the spleen. The evidence suggests that normal peritoneal cell populations and peripheral blood leukocytes contain hemopoietic stem-cell elements, with a frequency 30 to 50 times lower than among bone marrow cells. No evidence was adduced to support the concept that normal lymphoid tissue lymphocytes give rise to hemopoietic cell lines. (Author).
Spleen Colony Formation and Hemopoietic Restoration in Lethally X-irradiated Mice After Injection of Isogenic Peritoneal Cells
Nuclear Science Abstracts
U.S. Government Research Reports
Radiation Research
Radiology
Biological Abstracts
Author: Jacob Richard Schramm
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 1052
Book Description
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 1052
Book Description
Physical Factors and Modification of Radiation Injury
Bibliography of Scientific and Industrial Reports
Keywords Index to U.S. Government Technical Reports
Author:
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 1160
Book Description
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 1160
Book Description
Keywords Index to U.S. Government Technical Reports (permuted Title Index).
Author: United States. Department of Commerce. Office of Technical Services
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 836
Book Description
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 836
Book Description