Author: Richard Carroll ReemPublisher:
ISBN:
Category :
Languages : en
Pages : 728
Book Description
Spectroscopic Studies of the Binuclear Iron Active Site in Hemerythrin
Author: Richard Carroll ReemPublisher:
ISBN:
Category :
Languages : en
Pages : 728
Book Description
Spectroscopic Studies of Mixed-valent Binuclear Non-heme Iron Active Sites
Author: James Malcolm McCormickPublisher:
ISBN:
Category :
Languages : en
Pages : 536
Book Description
Spectroscopic and Theoretical Elucidation of Structural Contributions to Reactivity in Binuclear Non-heme Iron Enzymes
Author: Jennifer Kathleen SchwartzPublisher:
ISBN:
Category :
Languages : en
Pages : 568
Book Description
Spectroscopic and Theroretical Definition of Binuclear Non-heme Iron Active Sites
Author: Yi-Shan YangSpectroscopic and Structural Studeis [sic] of Core Variation in Binuclear Iron Families
![Spectroscopic and Structural Studeis [sic] of Core Variation in Binuclear Iron Families PDF](https://books.google.com/books/content/images/frontcover/3UsxAQAAIAAJ?fife=w80-h100)
Author: Pin-Pin WeiSpectroscopic Characterization of Binuclear Non-heme Iron and MN/FE Active Sites
Author: Yeonju KwakPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Binuclear non-heme iron enzymes catalyze various reactions including H-atom abstraction, desaturation, hydroxylation, and electrophilic aromatic substitution through O2 activation. In addition, they protect cells from oxidative stress and regulate iron levels in the cell. These enzymes utilize two irons and have common structural motif of 2-His / 4-carboxylate. Despite the enzymes' structural similarities, subtle changes at their active sites allow these enzymes to have different reactivities. Understanding the active site structures of these enzymes and the key mechanistic features related to these structures can provide a basis for potential applications: they could be drug inhibition targets to treat cancer, diabetes, and pathogenic diseases; they could work as biocatalysts; and they could carry out bioremediation reactions. In this dissertation, studies that examine three binuclear non-heme iron and Mn/Fe enzyme active sites (class Ic ribonucleotide reductase, ferritin variants, and bacterioferritin) and peroxo-bridged biferric model complexes are described. A combined spectroscopic methodology of nuclear resonance vibrational spectroscopy (NRVS), circular dichroism (CD), magnetic circular dichroism (MCD), and variable temperature, variable field (VTVH) MCD is used to probe geometric and electronic structures of Mn and Fe centers in protein active site and in model complexes.
Blood and Tissue Oxygen Carriers
Author: Charlotte P. MangumPublisher: Springer Science & Business Media
ISBN: 3642764185
Category : Medical
Languages : en
Pages : 468
Book Description
Investigations of the oxygen carriers range from the characterization of natural populations to measurements of tenths of nanometer distances between atoms. The scope is so great that few biologists and biochemists can fully comprehend the primary literature in its entirety. In addition, the findings of the past two or three decades have advanced the field so rapidly that a truly current account is not readily accessible to a general audience. In recognition of the problem a symposium was held and its proceedings published in the American Zoologist in 1980. Although it included several research reports, most of the contributions were intended to summarize then state-of-the-art information on molecular structure and respiratory function at a level that could be understood by biologists and biochemists who are not experts on our subject. Judging from the reprint requests with which the authors were inundated, the assessment of need had been accurate. I believe that the need for an update, which is wholly focused on communication to the general audience, is even greater in 1992. I therefore asked the authors of this volume to address individuals who might otherwise turn in vain to an advanced textbook of physiology or biochemistry. I have, of course, requested a more comprehensive coverage than would be possible in a general text, but one that is not more parochial. Just as textbooks differ vastly in the level at which their subject matter is presented, so the level of non-expertise was conceived differently by the contributors to this volume.
Author: Pierre Kennepohl
Author: Mark A. Pavlosky
Author: Jing Zhou