Special Issue on Inhalation Toxicology PDF Download

Author: Donald E. Gardner
Publisher:
ISBN:
Category : Air
Languages : en
Pages : 250

View

Book Description

Author: Donald E. Gardner
Publisher:
ISBN:
Category :
Languages : en
Pages : 4

View

Book Description

Author: HP Mahy (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :

View

Book Description

Author: R. O. McClellan
Publisher: Hemisphere Pub
ISBN: 9780891168058
Category : Medical
Languages : en
Pages : 560

View

Book Description

Author: Robert Frank
Publisher: ASTM International
ISBN:
Category : Air
Languages : en
Pages : 180

View

Book Description

Author: Mildred S. Christian
Publisher:
ISBN:
Category :
Languages : en
Pages : 109

View

Book Description
The focus of this symposium is the technology of nose exposure to rodents and the various kinds of measurements one can make before, during, and after exposure to obtain information about the dose and effects relative to the exposure. However, certain principles of inhalation exposure are common to all inhalation techniques. This introduction provides some historical perspectives in the development of both inhalation chambers and nose exposure techniques. It discusses the major advances in chamber design and nose exposure technology. The accumulation in and removal of test agents from the system is described. Two critical issues in inhalation studies, aerosol and vapor generation and techniques to measure the concentration of the test agents, are beyond the scope of this symposium and are not covered. Contents of volume 9, number 4 include the following topics: Basic Principles of Inhalation Exposure; Measurement of Respiration and Respiratory Responses During Inhalation Exposures; Whole-Body Plethysmography in Sedentary or Exercise Conditions to Determine Pulmonary Toxicity, Including Hypersensitivity Induced by Airborne Toxicant; Modernization of Nose-Only Smoking Machines for Use in Animal Inhalation Studies; An Exhaled Breath Chamber System for Assessing Rates of Metabolism and Rates of Gastrointestinal Absorption with Volatile Compounds; Large-Scale Assessment of Motor Activity in Rodents: Procedures For Routine Use in Toxicology Studies; Two-Stage Carcinogenesis and the Carcinogenecity of Phorbol Myristate Acetate (PMA).

Author: Philip Chi Lip Kwok
Publisher: CRC Press
ISBN: 131531195X
Category : Medical
Languages : en
Pages : 201

View

Book Description
The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Author: Fred J. Miller
Publisher: CRC Press
ISBN: 9781560323662
Category : Medical
Languages : en
Pages : 469

View

Book Description
The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because of the increased use of animal toxicological data for assessing human health risks from exposure to these compounds. This work addresses nasal dosimetry and toxicity of Inhaled Xenobiotics.; Originally Published As A Special Issue Of The journal "Inhalation Toxicology", the contributions are derived from a Chemical Industry Institute of Toxicology CIIT symposium held in September 1993 in Durham, North Carolina. The overview articles, covering topics like end points and responses of concern in humans, enable the reader to integrate information contained in later articles which treat the overview subjects in greater depth.; Next, mathematical and physical models that can be used to study the deposition of inhaled compounds in the upper respiratory tracts of humans and animals are considered. Approaches for experimental dosimetry studies and a number of dosimetry case studies are presented. The third series of articles examine chemically induced nasal responses in animals and humans. Integrating all the previous information, the final section discusses the use of nasal dosimetry and toxicity data for assessing human health implications and establishing appropriate exposure limits.

Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728

View

Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author: Marc Williams
Publisher: Elsevier
ISBN: 0128004800
Category : Science
Languages : en
Pages : 725

View

Book Description
Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.