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Author: Jürg P. Seiler Publisher: Springer Science & Business Media ISBN: 3642606822 Category : Medical Languages : en Pages : 396
Book Description
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Author: Jürg P. Seiler Publisher: Springer Science & Business Media ISBN: 3642606822 Category : Medical Languages : en Pages : 396
Book Description
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Author: Patrick M. Dansette Publisher: Springer Science & Business Media ISBN: 1461506670 Category : Science Languages : en Pages : 716
Book Description
This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Author: John Timbrell Publisher: Oxford University Press, USA ISBN: 0192804952 Category : Language Arts & Disciplines Languages : en Pages : 362
Book Description
Using reported disasters and everyday examples, this book examines both natural and man-made chemicals that we are exposed to. Illuminating the world of toxicology, it explains how they are toxic and the different reactions that individuals have to them. It also aims to debunk the popular belief that 'Natural is good, Man-made is bad'.
Author: Donald G. Barceloux Publisher: John Wiley & Sons ISBN: 047172761X Category : Science Languages : en Pages : 1196
Book Description
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. Medical Toxicology of Natural Substances finally gives you an easily accessible resource for vital toxicological information on foods, plants, and animals in key areas in the natural environment.
Author: Tony Burns Publisher: John Wiley & Sons ISBN: 1405141042 Category : Medical Languages : en Pages : 4193
Book Description
The late Arthur Rook established the Textbook of Dermatologyas the most comprehensive work of reference available to thedermatologist and it enjoys instant name recognition. Eachsubsequent edition has been expanded as the subject has developedand the book remains the ultimate source of clinical informationfor the trainee and practising dermatologist alike. Rook's Textbook of Dermatology covers all aspects of skindisease from basic science through pathology and epidemiology toclinical practice. Long recognized for its unparalleled coverage ofdiagnosis, this clinical classic earned its reputation as adefinitive source of information. New features of this Seventh Edition include: Two new Editors, Neil Cox and Christopher Griffiths, join theteam Every chapter is updated and several are completely rewrittenfrom scratch Completely new chapter on AIDS and the Skin Traditional emphasis on diagnosis preserved More coverage of treatment in each of the disease-specificchapters
Author: D Schrenk Publisher: Woodhead Publishing ISBN: 0081006756 Category : Technology & Engineering Languages : en Pages : 620
Book Description
Chemical Contaminants and Residues in Food, Second Edition is an invaluable tool for all industrial and academic researchers involved with food safety, from industry professionals responsible for producing safe food, to chemical analysts involved in testing the final products. This updated edition is expanded to cover the latest research and emerging issues, and has additional information useful for food safety testing. Written by an international team of expert contributors, this edition explores the entire food chain, acting as a roadmap for further research. - Includes expanded coverage on risk assessment and testing technologies - Presents fully updated chapters to provide the most up-to-date information in research on food chemical safety - Provides new information on hot topic areas, such as food additives, mycotoxins, nanomaterials and food contact materials
Author: Lyubomir A. Dourmishev Publisher: Springer Science & Business Media ISBN: 3540793135 Category : Medical Languages : en Pages : 344
Book Description
Although dermatomyositis is a rare connective tissue disease, many physicians are confronted with the diagnosis and treatment of patients affected by this condition. Based on the vast personal experience of the authors, who have diagnosed, treated, and managed many dermatomyositis patients, this clinical guide provides dermatologists, rheumatologists, pediatricians, neurologists, and general practitioners with the keys to interpreting the clinical symptoms of dermatomyositis. Also included are algorithms to help the reader to make the correct diagnosis, as well as guidance on new diagnostic methods and treatment schemes.
Author: Jürg P. Seiler
Author: Jürg P. Seiler
Author: Patrick M. Dansette
Author: John Timbrell
Author: 
Author: Donald G. Barceloux
Author: 
Author: Tony Burns
Author: D Schrenk
Author: 
Author: Lyubomir A. Dourmishev