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Author: George Wypych Publisher: ChemTec Publishing ISBN: 1895198240 Category : Science Languages : en Pages : 1446
Book Description
A comprehensive, extensive textual analysis of the principles of solvent selection and use, the handbook is intended to help formulators select ideal solvents, safety coordinators to protect workers, and legislators and inspectors to define and implement technically correct public safeguards for use, handling, and disposal.
Author: George Wypych Publisher: ChemTec Publishing ISBN: 1895198240 Category : Science Languages : en Pages : 1446
Book Description
A comprehensive, extensive textual analysis of the principles of solvent selection and use, the handbook is intended to help formulators select ideal solvents, safety coordinators to protect workers, and legislators and inspectors to define and implement technically correct public safeguards for use, handling, and disposal.
Author: Ian McN. Smallwood Publisher: CRC Press ISBN: 9780849316029 Category : Solvents Languages : en Pages : 440
Book Description
The pressure is on to cut plant emissions while still maintaining a cost-effective operation. Choosing the best solvent, being aware of potential problems, and the recovery of solvents has never been so important. Traditionally, solvents had been chosen on the basis of whether they can do the job effectively and economically. However, with regulations on exposure to solvent vapors becoming more stringent, selecting the solvent that meets regulatory, efficiency, and economical criteria as early as possible in the process has become paramount. Solvent Recovery Handbook, Second Edition sets out the physical properties of the fifty most commonly used solvents. The book supplies information on their behavior during and after use, health and fire hazards, the photochemical ozone creation potential (POCP), and recovery processes including practical aspects of the design and operation of batch stills. It delivers state-of-the art coverage of every available recovery and disposal technology - including removing solvents from gas, water, and residues, separating used solvents, and drying solvents. What's more, you'll find fact-filled sections on the latest equipment, safe effective operating procedures, choosing solvents with recovery in mind, and much more. Updated and expanded, Ian Smallwood's Solvent Recovery Handbook, Second Edition hands you all the practical tools you need to efficiently and cost-effectively process harmful organic solvents after re-capture.
Author: Patrick Augustijns Publisher: Springer Science & Business Media ISBN: 0387691545 Category : Medical Languages : en Pages : 466
Book Description
Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.
Author: Beverly Nickerson Publisher: Springer Science & Business Media ISBN: 1441996311 Category : Medical Languages : en Pages : 400
Book Description
This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. This book is divided into four parts: • Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. • Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms. • Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods. • Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.
Author: Stephen R. Byrn Publisher: John Wiley & Sons ISBN: 1119264448 Category : Science Languages : en Pages : 432
Book Description
Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time
Author: George Wypych
Author: George Wypych
Author: Ian McN. Smallwood
Author: United States. Patent and Trademark Office
Author: Patrick Augustijns
Author: 
Author: Beverly Nickerson
Author: Stephen R. Byrn
Author: 
Author: 
Author: United States. Patent Office