Solid-supported Combinatorial and Parallel Synthesis of Small-molecular-weight Compound Libraries PDF Download

Author: D. Obrecht
Publisher: Elsevier
ISBN: 9780080432571
Category : Science
Languages : en
Pages : 366

View

Book Description
This book gives an overview of the current state of the art of combinatorial organic synthesis. While the main focus is on multicomponent and multigeneration strategies using polymeric supports, there is also a Chapter on solution strategies using polymer-grafted reagents which allow minimisation of work-up procedures. Some of the most important strategies and tools are presented and summarised, with an explanation of the pivotal role of organic synthesis in the creation of diversity.

Author: Stephen R. Wilson
Publisher: John Wiley & Sons
ISBN: 9780471126874
Category : Medical
Languages : en
Pages : 288

View

Book Description
The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Author:
Publisher: Elsevier
ISBN: 0080497101
Category : Science
Languages : en
Pages : 607

View

Book Description
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis

Author: Lisa B. English
Publisher: Springer Science & Business Media
ISBN: 1592592856
Category : Science
Languages : en
Pages : 380

View

Book Description
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

Author: Stanislav Miertus
Publisher: CRC Press
ISBN: 0824758374
Category : Medical
Languages : en
Pages : 616

View

Book Description
Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Author: Guillermo A. Morales
Publisher: Academic Press
ISBN: 0121822729
Category : Amino acid sequence
Languages : en
Pages : 608

View

Book Description
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques *Direct sorting split and pool combinatorial synthesis *Linkers and their applications *Microwave assisted synthesis *Oligosaccharide chemistry *Peptide Synthesis and Screening *Polymer assisted approaches *Small molecule and heterocycle synthesis.

Author: Stanislav Miertus
Publisher: CRC Press
ISBN: 9781420000566
Category : Science
Languages : en
Pages : 456

View

Book Description
"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Author: Armen M. Boldi
Publisher: CRC Press
ISBN: 1000612015
Category : Science
Languages : en
Pages : 354

View

Book Description
Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Author: Günther Jung
Publisher: Wiley-VCH Verlag GmbH
ISBN:
Category : Medical
Languages : en
Pages : 648

View

Book Description
This is the most comprehensive and up-to-date source dealing with the latest developments in the field of combinatorial chemistry placing special emphasis on organic chemistry and biochemistry. It covers an interesting variety of synthetic and analytical topics.

Author: Nicholas K. Terrett
Publisher:
ISBN: 9780198502197
Category : Combinatorial chemistry
Languages : en
Pages : 204

View

Book Description
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.