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Author: Adèle Coriati Publisher: ISBN: Category : Languages : en Pages :
Book Description
Understanding the regulatory mechanisms controlling utrophin A expression at the sarcolemma of dystrophic muscles will facilitate the development of therapeutic strategies to ameliorate the pathophysiological features of Duchenne Muscular Dystrophy (DMD). The main goal of this study was to characterize the regulation of utrophin A IRES activity using a transgenic mouse model expressing the utrophin A 5'UTR bicistronic reporter and to identify trans-acting factors that could mediate IRES activity and endogenous expression of utrophin A. We found that utrophin A IRES activity is specifically expressed in skeletal muscles. Moreover, we identified eEF1A2 as a muscle-specific trans-acting factor that can interact with utrophin A and mediate IRES-dependent translation of utrophin A. Finally, we showed that eEF1A2 mediates endogenous utrophin A expression and localization in skeletal muscle. Identifying pharmacological compounds that would specifically target eEF1A2 and increase endogenous levels of utrophin A expression could serve as a drug-based therapy to treat DMD.
Author: Adèle Coriati Publisher: ISBN: Category : Languages : en Pages :
Book Description
Understanding the regulatory mechanisms controlling utrophin A expression at the sarcolemma of dystrophic muscles will facilitate the development of therapeutic strategies to ameliorate the pathophysiological features of Duchenne Muscular Dystrophy (DMD). The main goal of this study was to characterize the regulation of utrophin A IRES activity using a transgenic mouse model expressing the utrophin A 5'UTR bicistronic reporter and to identify trans-acting factors that could mediate IRES activity and endogenous expression of utrophin A. We found that utrophin A IRES activity is specifically expressed in skeletal muscles. Moreover, we identified eEF1A2 as a muscle-specific trans-acting factor that can interact with utrophin A and mediate IRES-dependent translation of utrophin A. Finally, we showed that eEF1A2 mediates endogenous utrophin A expression and localization in skeletal muscle. Identifying pharmacological compounds that would specifically target eEF1A2 and increase endogenous levels of utrophin A expression could serve as a drug-based therapy to treat DMD.
Author: Gisela Gaina Publisher: BoD – Books on Demand ISBN: 1837681554 Category : Medical Languages : en Pages : 116
Book Description
The book provides a comprehensive overview of the different forms of muscular dystrophy (MD), including potential therapeutic interventions and the advantages associated with repurposing pharmaceuticals for treating these conditions. In addition, the book examines the effects of physical training on improving symptoms as well as patient quality of life and life span. The target audience of this book comprises students, researchers, and doctors with an interest in the field of muscular dystrophy.
Author: Wayne S. Sossin Publisher: Oxford University Press ISBN: 0190686324 Category : Science Languages : en Pages : 512
Book Description
Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.
Author: Nahum Sonenberg Publisher: CSHL Press ISBN: 9780879696184 Category : Gene expression Languages : en Pages : 1034
Book Description
Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Author: Judith Campisi Publisher: ISBN: Category : Medical Languages : en Pages : 384
Book Description
Provides excellent overviews highlighting the research results of leading scientists as well as young investigators in the field of cellular and molecular regulatory mechanisms. How each cell grows and develops at the appropriate time and place is thoroughly covered along with such issues as culturing the types of cells which represent excellent model systems for studies on tumor formation, proliferation and differentiation; cell cycle control; molecular control of DNA replication and repair and much more.
Author: Adèle Coriati
Author: Adèle Coriati
Author: Adele Coriati
Author: Gisela Gaina
Author: Wayne S. Sossin
Author: Nahum Sonenberg
Author: Judith Campisi