Skeletal Muscle Plasticity and Energy Metabolism PDF Download

Author: Leonidas S. Lundell
Publisher:
ISBN: 9789176769096
Category :
Languages : en
Pages :

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Author: Jose Antonio
Publisher: Springer Science & Business Media
ISBN: 1597453021
Category : Science
Languages : en
Pages : 689

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This volume is a comprehensive textbook for the undergraduate course in sports nutrition. Focusing on exercise physiology, this text is to be used in a certification course sponsored by the International Society of Sports Nutrition (ISSN).

Author: Roberto Bottinelli
Publisher: Springer Science & Business Media
ISBN: 1402051778
Category : Medical
Languages : en
Pages : 372

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Book Description
The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes and mechanisms which form the background of muscle adaptation. This book aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.

Author: José Magalhães
Publisher:
ISBN: 9788130803227
Category : Muscles
Languages : en
Pages : 299

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Biological systems have acquired efficient adaptive strategies to cope with physiological challenges and to maximize biochemical processes under imposed constraints. All living organisms possess the inherent ability to change the structural and functional properties of their tissues in accordance to several health or disease-related conditions. Plasticity is the word used since the late 1970 s to designate all the processes and mechanisms behind adaptation. Muscle plasticity, in particular, is an unequivocal example of this biological feature. In fact, muscle is a very specialized tissue with an amazingly high malleability to adapt to distinct functional and metabolic demands by altering key molecular pathways. Moreover, as proposed in this book, muscle plasticity could also be extended to the ability of skeletal muscle to interact with other organs and mediate some of the stimuli-induced changes in other organs. Muscle cells are able to detect mechanical, metabolic, neuronal and hormonal signals which are transduced over multiple pathways to the muscle genome. Examples of muscle plasticity abound, from exercise adaptations, to the effects of environmental stressors, to the aging process, and to an assortment of disease-related conditions. Therefore, muscle plasticity forms a major basis for biological adaptation to physiological and pathophysiological conditions and thus, as we will become aware from the several chapters presented in this book, it can have both beneficial and maladaptive consequences. The goal of this multi-author book is to examine the current understanding regarding some physiological and biochemical events known to be involved in muscle adaptive response to altered health or disease-related circumstances. Notwithstanding the importance of other key organelles in cellular metabolism and function, muscle stimuli-targeting alterations in mitochondrial structure, biochemistry and function assume particular relevance throughout some chapters of this book. Issues related to muscle remodelling by physical exercise/contractile activity including molecular mechanisms of altered muscle use and hypertrophy, muscle disuse, aging processes, conditions of caloric restriction, hypoxia, as well as by some pathophysiological states such as obesity, cachexia, insulin resistance, diabetes mellitus, ischemia and ischemia-reperfusion make the scientific agenda of this book. As free radicals are known as powerful signalling molecules in cellular metabolism, a special emphasis on muscle redox-based modulation is noticeable throughout this book. However, even though this book covers a wide range of knowledge, it does not examine all aspects of physiology and biochemistry of muscle plasticity. Among many others, these would include several issues, such as inflammation, atrophy, satellite cell function in regeneration, regulation of excitation-contraction coupling, muscle architecture, as well as the response of muscle to distinct pharmacological agents. Topics like these are approached in other expertise devoted reviews. We are delighted to be involved in this project and gratefully acknowledged to the outstanding contribution of the authors. We hope that this book will be of interest to a wide basic and applied biomedical science audience, from physiologists to biochemists, especially those that embrace with excitement the wonders of muscle plasticity. Lastly, we also hope that the fascinating scientific platform of muscle plasticity would foster a plasticity of mind in developing new hypotheses and approaching challenges.

Author: Kunihiro Sakuma
Publisher: Springer
ISBN: 9811032920
Category : Medical
Languages : en
Pages : 295

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This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis. The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered. It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle.

Author: Christopher Myers
Publisher: Springer Nature
ISBN: 3031470656
Category :
Languages : en
Pages : 325

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Author: Bruce Spiegelman
Publisher: Springer
ISBN: 3319727907
Category : Science
Languages : en
Pages : 108

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The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Author: Allen Leung
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Biological processes resulting in observable cell state changes, such as synaptic plasticity inneuronal dendritic spines and muscular hypertrophy in skeletal muscles, share common characteristics. Both are influenced by calcium signaling, metabolic networks, mitochondria, and protein kinase activation. This research presents computational models of these processes, offering insights into synaptic plasticity and the skeletal muscle response to exercise. The first model is a spatial representation of mitochondrial ATP generation during calcium signaling in neurons, emphasizing the role of mitochondrial ER contact sites in increasing calcium levels in the mitochondria, thus enhancing mitochondrial potential. This model underscores the importance of subcellular geometry, metabolic consumption rates, and transport processes in ATP production, in addition to enzymatic activity. The second model is a compartmental model exploring the role of signaling frequency in protein kinase activation in dendritic spines. This model analyzes the interaction between the canonical neuronal signaling cascade, the AMP-Activated Protein Kinase (AMPK) cascade, and the insulin signaling cascade in conditions of high neurotransmitter stimulation rates, which activate calcium signaling and consume significant cellular energy. The final model, a logic-based representation of skeletal muscle signaling in response to resistance, endurance, and sprint exercise, investigates potential mechanisms of exercise-induced changes in mitochondrial morphology. Together, these models deepen our understanding of the dynamic interplay between signaling and metabolism in synaptic plasticity and exercise physiology, laying the groundwork for further investigation and potential development of therapeutic strategies for neurological disorders and improvements in exercise efficiency.

Author: Mark Hargreaves
Publisher: Human Kinetics
ISBN: 9780736041034
Category : Energy metabolism
Languages : en
Pages : 320

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Book Description
A comprehensive reference for biochemists, sport nutritionists, exercise physiologists, and graduate students in those disciplines. Provides information on the metabolic processes that take place during exercise, examining in depth the mobilization and utilization of substrates during physical activity. Focuses primarily on the skeletal muscle, but also discusses the roles of the liver and adipose tissue. Annotation copyright by Book News, Inc., Portland, OR

Author: Karin Söderlund
Publisher:
ISBN:
Category :
Languages : en
Pages : 50

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