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Author: Kunal Mitra Publisher: Springer ISBN: 3319542532 Category : Technology & Engineering Languages : en Pages : 53
Book Description
This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as well as researchers, clinicians, and technicians. Short pulse laser systems are useful for both subsurface tissue imaging and laser induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performed to characterize the tissue optical properties needed to optimize the dose for thermal therapy. Experiments were then performed on animal models to characterize the heat affected zone for LITT. The experimental measurements were also validated using the computational models.
Author: Kunal Mitra Publisher: Springer ISBN: 3319542532 Category : Technology & Engineering Languages : en Pages : 53
Book Description
This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as well as researchers, clinicians, and technicians. Short pulse laser systems are useful for both subsurface tissue imaging and laser induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performed to characterize the tissue optical properties needed to optimize the dose for thermal therapy. Experiments were then performed on animal models to characterize the heat affected zone for LITT. The experimental measurements were also validated using the computational models.
Author: Stefan Nolte Publisher: Springer ISBN: 3319176595 Category : Science Languages : en Pages : 365
Book Description
Ultrashort laser pulses with durations in the femtosecond range up to a few picoseconds provide a unique method for precise materials processing or medical applications. Paired with the recent developments in ultrashort pulse lasers, this technology is finding its way into various application fields. The book gives a comprehensive overview of the principles and applications of ultrashort pulse lasers, especially applied to medicine and production technology. Recent advances in laser technology are discussed in detail. This covers the development of reliable and cheap low power laser sources as well as high average power ultrashort pulse lasers for large scale manufacturing. The fundamentals of laser-matter-interaction as well as processing strategies and the required system technology are discussed for these laser sources with respect to precise materials processing. Finally, different applications within medicine, measurement technology or materials processing are highlighted.
Author: Publisher: ISBN: Category : Languages : en Pages :
Book Description
During the three year LDRD funding period, we studied the ablation characteristics of biological tissues using ultrashort pulse lasers (USPL) with pulse widths varying from 100 femtoseconds to tens of picoseconds. During the first year, we performed extensive theoretical studies to develop an improved understanding of the USPL ablation process. Two optical signals were tested for feasibility of use in real-time feedback systems during high repetition rate ablation. In the second year, we devised a real-time, feedback-controlled USPL ablation system, based on luminescence, which may be useful for sensitive micro-spinal surgeries. Effective laser parameters were identified to reduce collateral damage. The final year of the project focused on quantification of the pressure pulse induced by USPL ablation of water surfaces representing biological tissues. Results of these studies were presented in invited talks at domestic and international conferences and numerous journal articles were published (see bibliography). This effort has increased our scientific understanding of physical processes important for the therapeutic biomedical application of ultrashort pulse lasers, and has taken the first steps toward practical realization of such applications.
Author: Joseph Neev Publisher: ISBN: 9780071627320 Category : Technology & Engineering Languages : en Pages : 0
Book Description
Handbook of ultra-short pulse lasers for biomedical and medical applications is written for biophotonics scientists and engineers who are collaborating with medical professions in developing the medical tools which utilizes ultra-short pulse lasers. This book illustrates fundamental physics of USPLs and how they interact with human tissues through ample examples of practical applications. Medical professionals who are interested in the latest updates of laser surgery and diagnosis through laser imaging will also benefit from this book.
Author: Leon Goldman Publisher: Springer Science & Business Media ISBN: 1461259223 Category : Technology & Engineering Languages : en Pages : 341
Book Description
The laser's range of application is extraordinary. Arthur Schawlow says, "What instrument can shuck a bucket of oysters, correct typing errors, fuse atoms, lay a straight line for a garden bed, repair detached retinas, and drill holes in dia monds?"O The laser's specifically biomedical uses cover a similarly broad and interesting spectrum. In this book, I have endeavored to convey some of the fas cination that the laser has long held for me. It is my hope that both clinicians and researchers in the various medical and surgical specialties will find the book a use ful introduction. Biologists, particularly molecular biologists, should also find a great deal of relevant information herein. This volume's distinguished contributors provide admirably lucid discussions of laser principles, instrumentation, and current practice in their respective special ties. Safety, design, capabilities, and costs of various lasers are also reviewed. We have aimed to create a practical text that is comprehensive but not exhaustive. Our emphasis on the practical, rather than the esoteric, is dictated not only by the short history of biomedical laser use, but by the extent of the community to which this information will appeal.
Author: Leon Goldman Publisher: Springer Science & Business Media ISBN: 3642857973 Category : Medical Languages : en Pages : 241
Book Description
This book is a review of past and current studies and future plans of the Laser Laboratory in Cincinnati and some of the contributions of laser research groups in other medical centers. Special thanks are due to the Directing Physicist of the Laser Labora tory, R. James Rockwell. Without his advice, constant supervision and corrections, this enthusiastic investigator would continue to upset even many more people than he has done already. The excuse, of course, is to stimulate much needed interest and controlled research and development of the laser for biology and medicine. The Associate Research Physicist, Ralph Schooley, has worked with many phases of laser research but especially in Q spoiling, Raman spectroscopy, and the almost alchemy of holography. Holography, as of now, provides many opportunities for Gumperson's Law, "If anything can go wrong, it will. " Sincere appreciation is expressed to the Surgeons in the Laser Labora tory, who have supplied clinical and investigative surgical supervision often under great difficulties, Dr. V. E. Siler and Dr. Bruce Henderson. We are grateful for help from the Directing Biologist of the Laser Labo ratory, Edmond Ritter, the Director of Laser Neurosurgery, Dr. Thomas Brown and the Professor of Neurosurgery, Dr. Robert McLaurin, for important and basic work in laser neurosurgery. Special thanks are given to Robert Meyer, who has given most of the treatments in careful and skillful fashion, and his associate, Robert Otten.
Author: Markus Braun Publisher: Springer Science & Business Media ISBN: 3540735666 Category : Science Languages : en Pages : 326
Book Description
Learn about the many biological and medical applications of ultrashort laser pulses. The authors highlight and explain how the briefness of these laser pulses permits the tracing of even the fastest processes in photo-active bio-systems. They also present a variety of applications that rely on the high peak intensity of ultrashort laser pulses. Easy-to-follow examples cover non-linear imaging techniques, optical tomography, and laser surgery.
Author: Kunal Mitra
Author: Kunal Mitra
Author: 
Author: Stefan Nolte
Author: 
Author: Joseph Neev
Author: Leon Goldman
Author: Richard F. Haglund
Author: Glenn S. Edwards
Author: Leon Goldman
Author: Markus Braun