Serum Alpha-fetoprotein (afp) And/or Ultrasound (us) for Hepatocellular Carcinoma (hcc) Screening PDF Download

Author:
Publisher:
ISBN: 9789670399362
Category : Liver
Languages : en
Pages : 56

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Author: Yujin Hoshida
Publisher: Springer
ISBN: 3030215407
Category : Medical
Languages : en
Pages : 366

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Book Description
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Author: Brian I. Carr
Publisher: Springer Science & Business Media
ISBN: 160327376X
Category : Medical
Languages : en
Pages : 752

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Book Description
Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of embolization, and the significance of portal vein thrombus. New chapters discuss the introduction into clinical practice of cell cycle growth inhibitors, an expanded knowledge of Genomics and Proteomics, and novel ways of delivering intra-hepatic chemotherapy. This cutting-edge text is a vital resource and must have for today’s hepatologists and medical and surgical oncologists.

Author: Feng Su
Publisher:
ISBN:
Category :
Languages : en
Pages : 30

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Background: Patients with chronic hepatitis B (CHB) infection often undergo screening for hepatocellular carcinoma (HCC), but the efficacy of such screening remains unclear. We aimed to evaluate the impact of screening with ultrasound (USS) and/or serum alpha-fetoprotein (AFP) on HCC-related mortality in Veterans Affairs (VA) patients with CHB. Methods: We performed a matched case-control study. Patients with CHB and at least 4 years of VA care after CHB diagnosis were identified. Cases were patients who died of HCC between 01/01/2004 and 12/31/2017, while controls were patients who did not die of HCC. Cases and controls were matched by CHB diagnosis date, age, sex, race/ethnicity, cirrhosis status, antiviral therapy exposure, hepatitis B e antigen status, and viral load. We identified screening USS and AFPs obtained in the 4 years preceding HCC diagnosis in cases and the equivalent index date in controls. Using conditional logistic regression, we compared cases and controls with respect to receipt of screening. A lower likelihood of screening in cases corresponds to an association between screening and reduced risk of HCC-related mortality. Results: We identified 169 cases, matched to 169 controls. Fewer cases than controls underwent screening with either screening modality (33.7% versus 58.6%) or both modalities (19.5% versus 34.4%). In multivariable conditional logistic regression, screening with either modality was associated with a lower risk of HCC-related mortality (adjusted odds ratio [aOR] 0.21, 95% confidence interval [CI] 0.09-0.50), as was screening with both modalities (aOR of 0.13, 95% CI 0.04-0.43). Conclusions: HCC screening was associated with a substantial reduction in HCC-related mortality in VA patients with CHB.

Author: Quyen D Chu
Publisher: Beaux Books Publishing, LLC
ISBN: 0997772182
Category : Medical
Languages : en
Pages : 1352

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This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.

Author:
Publisher: Academic Press
ISBN: 012817739X
Category : Science
Languages : en
Pages : 418

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Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Author: Edward L. Krawitt
Publisher: Elsevier Science Health Science Division
ISBN: 9780444828033
Category : Medical
Languages : en
Pages : 656

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The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.

Author: Byung Ihn Choi
Publisher: Springer Science & Business Media
ISBN: 364235825X
Category : Medical
Languages : en
Pages : 835

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Book Description
Radiology Illustrated: Hepatobiliary and Pancreatic Radiology is the first of two volumes that will serve as a clear, practical guide to the diagnostic imaging of abdominal diseases. This volume, devoted to diseases of the liver, biliary tree, gallbladder, pancreas, and spleen, covers congenital disorders, vascular diseases, benign and malignant tumors, and infectious conditions. Liver transplantation, evaluation of the therapeutic response of hepatocellular carcinoma, trauma, and post-treatment complications are also addressed. The book presents approximately 560 cases with more than 2100 carefully selected and categorized illustrations, along with key text messages and tables, that will allow the reader easily to recall the relevant images as an aid to differential diagnosis. At the end of each text message, key points are summarized to facilitate rapid review and learning. In addition, brief descriptions of each clinical problem are provided, followed by both common and uncommon case studies that illustrate the role of different imaging modalities, such as ultrasound, radiography, CT, and MRI.

Author: Tim Cross
Publisher: Springer
ISBN: 3319922165
Category : Medical
Languages : en
Pages : 312

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This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

Author: Kathleen Deska Pagana
Publisher: Elsevier Health Sciences
ISBN: 0323609686
Category : Medical
Languages : en
Pages : 1088

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Book Description
Get the latest research and easy access to today’s most important diagnostic and lab tests! Known for its accuracy, currency, and clear, easy-to-use format, Mosby’s Diagnostic & Laboratory Test Reference 14th Edition features concise test entries that are arranged alphabetically and reflect the latest in diagnostic and lab testing and research. This new edition adds 15 tests with vital information such as alternate or abbreviated test names, test explanation, normal and abnormal findings, possible critical values, and guidelines to patient care before, during, and after the test. Plus, all related tests are cross-referenced throughout the book to simplify lookup. A compact size, durable cover, and A-to-Z thumb tabs make this market-leading book ideal for everyday use in the classroom and on the job! Alphabetically organized tests offer quick reference with A-to-Z thumb tabs, so you will never have to search for a test by having to first determine its correct category or body system. Normal findings for adult, elderly, and pediatric patients are included where applicable. Abnormal findings are highlighted with directional arrows to show increased or decreased test results. Convenient appendix lists tests by body system and test type, making it easy to quickly locate related studies. A durable cover with rounded edges helps prevent the book from being damaged and makes it easier to handle. Each test entry begins on a new page, making tests easy to find. Possible critical values are highlighted to show situations requiring immediate intervention. Icon for patient teaching-related care indicates information that should be shared with patients and their families. User’s Guide to Test Preparation and Performance provides an overview and guidelines for each type of laboratory test and diagnostic procedure, so you can minimize worry about having to repeat a test due to an error. Abbreviations for tests are listed in the back of the book, and symbols and units of measurement are listed in an appendix. Cross-referencing of related tests makes them easy to find. NEW! Test entries include the latest diagnostic tests and laboratory procedures, featuring 10 new monographs and 15 additional tests. NEW! Content reflects the latest research on the diagnostic values of results, accuracy of testing, and patient care and education for each test. NEW! Common Reference Ranges section added to the Inside Front Cover material.