Author: James Whisstock
Publisher: Academic Press
ISBN: 0123859506
Category : Medical
Languages : en
Pages : 562
Book Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. This volume in the Methods in Enzymology series comprehensively covers the topic of serpins With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
Serpin Structure and Evolution
Biology of Serpins
Author: James Whisstock
Publisher: Academic Press
ISBN: 0123864712
Category : Medical
Languages : en
Pages : 461
Book Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.
Publisher: Academic Press
ISBN: 0123864712
Category : Medical
Languages : en
Pages : 461
Book Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.
Chemistry and Biology of Serpins
Author: Frank C. Church
Publisher: Springer Science & Business Media
ISBN: 1461553911
Category : Science
Languages : en
Pages : 363
Book Description
Proceedings of an International Symposium held in Chapel Hill, North Carolina, April 13-16, 1996
Publisher: Springer Science & Business Media
ISBN: 1461553911
Category : Science
Languages : en
Pages : 363
Book Description
Proceedings of an International Symposium held in Chapel Hill, North Carolina, April 13-16, 1996
Serpin Structure and Evolution
Author:
Publisher: Academic Press
ISBN: 0123859514
Category : Science
Languages : en
Pages : 562
Book Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. - This volume in the Methods in Enzymology series comprehensively covers the topic of serpins - With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
Publisher: Academic Press
ISBN: 0123859514
Category : Science
Languages : en
Pages : 562
Book Description
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. - This volume in the Methods in Enzymology series comprehensively covers the topic of serpins - With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity
Author: Gary A. Silverman
Publisher: World Scientific
ISBN: 9812707549
Category : Medical
Languages : en
Pages : 671
Book Description
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
Publisher: World Scientific
ISBN: 9812707549
Category : Medical
Languages : en
Pages : 671
Book Description
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
The Serpin Family
Author: Margarethe Geiger
Publisher: Springer
ISBN: 3319227114
Category : Science
Languages : en
Pages : 333
Book Description
The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.
Publisher: Springer
ISBN: 3319227114
Category : Science
Languages : en
Pages : 333
Book Description
The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.
The Serpin Family in the Cardiovascular System
Author: Marie-Christine Bouton
Publisher: Frontiers Media SA
ISBN: 2889745724
Category : Medical
Languages : en
Pages : 166
Book Description
Publisher: Frontiers Media SA
ISBN: 2889745724
Category : Medical
Languages : en
Pages : 166
Book Description
Proteases in Health and Disease
Author: Enrico Di Cera
Publisher: Academic Press
ISBN: 0123855047
Category : Medical
Languages : en
Pages : 336
Book Description
Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Publisher: Academic Press
ISBN: 0123855047
Category : Medical
Languages : en
Pages : 336
Book Description
Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Mechanisms of Catalysis
Author:
Publisher: Academic Press
ISBN: 0080865968
Category : Technology & Engineering
Languages : en
Pages : 471
Book Description
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
Publisher: Academic Press
ISBN: 0080865968
Category : Technology & Engineering
Languages : en
Pages : 471
Book Description
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
Serpins
Author: Alexandra Lucas
Publisher:
ISBN: 9781493986453
Category : Biochemistry
Languages : en
Pages : 276
Book Description
This volume explores the latest methods used to study and define serpin molecular structure, basic protease inhibition, serpin targets, and the roles of serpin in biology and disease using animal models. The chapters in this book cover topics such as crystallography and phage display, peptide design, phospholipid binding, and thrombus formation to microbiome analysis and development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Serpins: Methods and Protocols is a valuable resource for researchers and scientists interested in learning more about this evolving field.
Publisher:
ISBN: 9781493986453
Category : Biochemistry
Languages : en
Pages : 276
Book Description
This volume explores the latest methods used to study and define serpin molecular structure, basic protease inhibition, serpin targets, and the roles of serpin in biology and disease using animal models. The chapters in this book cover topics such as crystallography and phage display, peptide design, phospholipid binding, and thrombus formation to microbiome analysis and development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Serpins: Methods and Protocols is a valuable resource for researchers and scientists interested in learning more about this evolving field.