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Author: Claude Martin Publisher: Springer Science & Business Media ISBN: 9782287220722 Category : Medical Languages : fr Pages : 348
Book Description
Le sepsis sévère et le choc septique sont des maladies fréquentes et grevées d’une mortalité importante allant de 30 à plus de 70 %. Seule une bonne connaissance de la physiopathologie permet de choisir les bonnes stratégies thérapeutiques afin de limiter la mortalité. Cet ouvrage, le plus complet sur le sujet, présente en détails, mais de façon compréhensible les éléments majeurs de la physiopathologie. Il intègre les définitions actualisées du sepsis, du sepsis sévère et du choc septique. Il rassemble des données habituellement éparses sur la réanimation du sepsis grave ainsi que sur le traitement antibiotique et fait le point sur les avancées thérapeutiques récentes : corticothérapie, protéine C activée, vasopressine et terlipressine.
Author: Claude Martin Publisher: Springer Science & Business Media ISBN: 9782287220722 Category : Medical Languages : fr Pages : 348
Book Description
Le sepsis sévère et le choc septique sont des maladies fréquentes et grevées d’une mortalité importante allant de 30 à plus de 70 %. Seule une bonne connaissance de la physiopathologie permet de choisir les bonnes stratégies thérapeutiques afin de limiter la mortalité. Cet ouvrage, le plus complet sur le sujet, présente en détails, mais de façon compréhensible les éléments majeurs de la physiopathologie. Il intègre les définitions actualisées du sepsis, du sepsis sévère et du choc septique. Il rassemble des données habituellement éparses sur la réanimation du sepsis grave ainsi que sur le traitement antibiotique et fait le point sur les avancées thérapeutiques récentes : corticothérapie, protéine C activée, vasopressine et terlipressine.
Author: George H. Sakorafas Publisher: Nova Publishers ISBN: 9781594541681 Category : Medical Languages : en Pages : 128
Book Description
Sepsis is one of the most frequent complications in the surgical patient and one of the leading causes of mortality in intensive care units. During the past two decades, a great deal has been learned about surgical bacteriology, antibiotic prophylaxis, supportive management, and the host response to microbial invasion. Sepsis can be caused by infection with gram-negative bacteria, gram-positive bacteria, fungi (and particularly Candida), or viruses. Sepsis may also occur in the absence of detectable bacterial invasion, and in these cases, microbial toxins, particularly gram-negative bacterial endotoxin (lipopolysaccharide, LPS), and endogenous cytokine production have been implicated as initiators and mediators. Although activation of the immune system during microbial invasion is generally protective, septic shock develops in a significant number of patients as a consequence of a poorly regulated immune response to the offending organism. Sepsis can be presented with a spectrum of severity. Septic shock represents the most severe form of host response to infection. The aim of this monograph is to summarise the currently available data regarding epidemiology, pathogenesis, and optimal management of septic shock, with a particular emphasis on the role of source control in sepsis. Emerging therapies for septic shock are also discussed.
Author: Peter Q. Eichacker Publisher: Springer Science & Business Media ISBN: 1461515815 Category : Medical Languages : en Pages : 214
Book Description
Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.
Author: H. Redl Publisher: Springer ISBN: 3034887558 Category : Medical Languages : en Pages : 377
Book Description
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.
Author: Jordi Rello Publisher: Springer Science & Business Media ISBN: 3642035191 Category : Medical Languages : en Pages : 243
Book Description
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.
Author: Jean-Louis Vincent Publisher: Springer Science & Business Media ISBN: 0306476649 Category : Medical Languages : en Pages : 848
Book Description
This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.
Author: Derek J. Chadwick Publisher: John Wiley & Sons ISBN: 0470059583 Category : Medical Languages : en Pages : 304
Book Description
Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.
Author: Günther Schlag Publisher: Springer Science & Business Media ISBN: 3642586309 Category : Medical Languages : en Pages : 461
Book Description
At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.
Author: Jean-Marc Cavaillon Publisher: John Wiley & Sons ISBN: 9783527319350 Category : Science Languages : en Pages : 456
Book Description
Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.
Author: Claude Martin
Author: Claude Martin
Author: George H. Sakorafas
Author: Peter Q. Eichacker
Author: H. Redl
Author: Jordi Rello
Author: Jean-Louis Vincent
Author: Derek J. Chadwick
Author: Günther Schlag
Author: Jean-Marc Cavaillon
Author: Emmanuelle Dubois