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Author: T. Nagylaki Publisher: Springer Science & Business Media ISBN: 3642930611 Category : Medical Languages : en Pages : 216
Book Description
Most of these notes were presented as part of a two-quarter course on theoretical population genetics at The University of Chicago. Almost all the students were either undergraduates in mathematics or graduate students in the biological sciences. The only prerequisites were calculus and matrices. As is done in these notes, biological background and additional mathematical techniques were covered when they were required. I have included the relevant problems assigned in the course. My aim in these notes is to formulate the various models fairly generally, making the biological assumptions quite explicit, and to perform the analyses relatively rigorously. I hope the choice and treatment of topics will enable the reader to understand and evaluate detailed analyses of specific models and applications in the literature. No attempt has been made to review the literature or to assign credit. Most of the references are to papers directly germane to the subjects and approaches covered here. Frequency of reference is not intended to reflect proportionate contribution. I am very grateful to Professor James F. Crow for helpful comments and to Mrs. Adelaide Jaffe for her excellent typing. I thank the National Science Foundation for its support (Grant No. DEB76-01550).
Author: T. Nagylaki Publisher: Springer Science & Business Media ISBN: 3642930611 Category : Medical Languages : en Pages : 216
Book Description
Most of these notes were presented as part of a two-quarter course on theoretical population genetics at The University of Chicago. Almost all the students were either undergraduates in mathematics or graduate students in the biological sciences. The only prerequisites were calculus and matrices. As is done in these notes, biological background and additional mathematical techniques were covered when they were required. I have included the relevant problems assigned in the course. My aim in these notes is to formulate the various models fairly generally, making the biological assumptions quite explicit, and to perform the analyses relatively rigorously. I hope the choice and treatment of topics will enable the reader to understand and evaluate detailed analyses of specific models and applications in the literature. No attempt has been made to review the literature or to assign credit. Most of the references are to papers directly germane to the subjects and approaches covered here. Frequency of reference is not intended to reflect proportionate contribution. I am very grateful to Professor James F. Crow for helpful comments and to Mrs. Adelaide Jaffe for her excellent typing. I thank the National Science Foundation for its support (Grant No. DEB76-01550).
Author: National Research Council Publisher: National Academies Press ISBN: 0309134404 Category : Science Languages : en Pages : 270
Book Description
In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.
Author: Marion E. Reid Publisher: Academic Press ISBN: 0124158498 Category : Medical Languages : en Pages : 758
Book Description
The Blood Group Antigen FactsBook has been an essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990s.The third edition of The Blood Group Antigen FactsBook has been completely revised, updated and expanded to cover all 32 blood group systems. It blends scientific background and clinical applications and provides busy researchers and clinicians with at-a-glance information on over 330 blood group antigens, including history and information on terminology, expression, chromosomal assignment, carrier molecular description, functions, molecular bases of antigens and phenotypes, effect of enzymes/chemicals, clinical significance, disease associations and key references. Includes over 330 entries on blood group antigens in individual factsheetsOffers a logical and concise catalogue structure for each antigen in an improved interior design for quick reference. Written by 3 international experts from the field of immunohematology and transfusion medicine.
Author: Robert Trivers Publisher: Oxford University Press, USA ISBN: 0195130626 Category : Language Arts & Disciplines Languages : en Pages : 356
Book Description
From scholarly journals, Trivers (anthropology and biological sciences, Rutgers U.) has selected five of his papers published between 1971 and 1976, and another five published between 1982 and 2000. He has added accounts of how they were written, and short postscripts to bring readers up to date or at least point them to more recent work on the issues discussed. Annotation (c)2003 Book News, Inc., Portland, OR (booknews.com).
Author: A. Rus Hoelzel Publisher: John Wiley & Sons ISBN: 1444311336 Category : Science Languages : en Pages : 448
Book Description
This book provides a general introduction to the biology of marine mammals, and an overview of the adaptations that have permitted mammals to succeed in the marine environment. Each chapter, written by experts in their field, will provide an up-to-date review and present the major discoveries and innovations in the field. Important technical advances such as satellite telemetry and time-depth-recorders will be described in boxes.
Author: Bruce Walsh Publisher: Oxford University Press ISBN: 0192566644 Category : Science Languages : en Pages : 1504
Book Description
Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.
Author: Warren J. Ewens Publisher: Springer Science & Business Media ISBN: 9780387201917 Category : Science Languages : en Pages : 448
Book Description
This is the first of a planned two-volume work discussing the mathematical aspects of population genetics with an emphasis on evolutionary theory. This volume draws heavily from the author’s 1979 classic, but it has been revised and expanded to include recent topics which follow naturally from the treatment in the earlier edition, such as the theory of molecular population genetics.
Author: Jean Peccoud Publisher: Humana Press ISBN: 9781617795633 Category : Medical Languages : en Pages : 297
Book Description
The de novo fabrication of custom DNA molecules is a transformative technology that significantly affects the biotechnology industry. Basic genetic engineering techniques for manipulating DNA in vitro opened an incredible field of opportunity in the life sciences. In, Gene Synthesis: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to fabricate DNA . These include methods and techniques for the assembly of oligonucleotide, cloning of synthons into larger fragments, protocols and software applications, and educational and biosecurity impacts of gene synthesis. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Gene Synthese: Methods and Protocols aids scientists in understanding all the different stages of a complex gene synthesis process, while refining their understanding of gene synthesis and determine what part of the process they can or should do in their laboratory and what parts should be contracted to a specialized service provider.
Author: Costas B. Krimbas Publisher: CRC Press ISBN: 9780849365478 Category : Science Languages : en Pages : 680
Book Description
Inversion polymorphism in Drosophila has long served as a research subject for a variety of evolutionary studies and continues to be extremely important in understanding evolutionary principles today. Until now, no single volume has ever been assembled as a summary of this work. Drosophila Inversion Polymorphism provides background information, explores new and rigorous approaches to reconstructing phylogenetic relationships from inversion variation, and discusses inversion polymorphism in the six most studied species groups. Some chapters examine general principles and conclusions, some present detailed data sets (many of which have never before been published), and others offer detailed chromosome maps for identification. The book is a one-of-a-kind source of summary discussions and data ripe for analysis. Geneticists, evolutionary biologists, biologists, and all investigators researching inversion polymorphisms should consider Drosophila Inversion Polymorphism a "must-have" volume.
Author: Thomas Nagylaki Publisher: Springer Science & Business Media ISBN: 364276214X Category : Science Languages : en Pages : 381
Book Description
This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. I have tried to formulate the various models fairly generally and to state the biological as sumptions quite explicitly. I hope the choice and treatment of topics will en able the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. Models in population genetics are highly idealized, often even over idealized, and their connection with observation is frequently remote. Further more, it is not practicable to measure the parameters and variables in these models with high accuracy. These regrettable circumstances amply justify the use of appropriate, lucid, and rigorous approximations in the analysis of our models, and such approximations are often illuminating even when exact solu tions are available. However, our empirical and theoretical limitations justify neither opaque, incomplete formulations nor unconvincing, inadequate analy ses, for these may produce uninterpretable, misleading, or erroneous results. Intuition is a principal source of ideas for the construction and investigation of models, but it can replace neither clear formulation nor careful analysis. Fisher (1930; 1958, pp. x, 23-24, 38) not only espoused similar ideas, but he recognized also that our concepts of intuition and rigor must evolve in time. The book is neither a review of the literature nor a compendium of results. The material is almost entirely self-contained. The first eight chapters are a thoroughly revised and greatly extended version of my published lecture notes (Nagylaki, 1977a).
Author: T. Nagylaki
Author: T. Nagylaki
Author: National Research Council
Author: Marion E. Reid
Author: Robert Trivers
Author: A. Rus Hoelzel
Author: Bruce Walsh
Author: Warren J. Ewens
Author: Jean Peccoud
Author: Costas B. Krimbas
Author: Thomas Nagylaki