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Author: Marta Del Olmo Publisher: ISBN: 9783832554064 Category : Languages : en Pages : 234
Book Description
Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
Author: Marta Del Olmo Publisher: ISBN: 9783832554064 Category : Languages : en Pages : 234
Book Description
Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
Author: Paul Kelley Publisher: John Catt ISBN: 1398382558 Category : Psychology Languages : en Pages : 226
Book Description
Our body's clocks make the difference between happiness and depression, health and illness, and even life and death. The brilliant scientist Paul Kelley makes a compelling case for all organisations to allow people to work and study the hours that suit their personal circadian rhythms. That way, Paul argues, we would all be more productive, a great deal of ill health would be avoided and the world would be a better and happier place.
Author: Leon Kreitzman Publisher: Profile Books ISBN: 1847653723 Category : Science Languages : en Pages : 288
Book Description
Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.
Author: Michael Smolensky Publisher: Macmillan + ORM ISBN: 1466891467 Category : Health & Fitness Languages : en Pages : 679
Book Description
A medical breakthrough explained by the leading authority on the connection between health and your body clock Chronotherapy-adjusting the care of the body to coincide with the body's natural clock-is poised to be the next major revolution in medical science. An understanding and awareness of these rhythms will enable us to maximize the effects not only of medications and other treatments, but also of diets, exercise programs, and other daily routines. The Body Clock Guide to Better Health combines a detailed discussion of major issues such as sleep, exercise, and nutrition, with a comprehensive A-to-Z reference to specific disorders. Among the health concerns it addresses are AIDS, arthritis, asthma, ADD, backache, cancer, depression, diabetes, digestive problems, allergies, heart disease, chronic pain, sexual dysfunction, stroke, and complications from pregnancy. General chapters explore the big picture-including monthly cycles and life cycles-and provide invaluable advice on foods and dietary supplements, fitness, better sex, jet lag, and more. The first book to look at body rhythms from a practical perspective, The Body Clock Guide to Better Health offers readers the dual benefits of improving the treatment of specific conditions while boosting their overall health and wellness.
Author: Carol Orlock Publisher: Citadel Press ISBN: Category : Chronobiology Languages : en Pages : 216
Book Description
Crops. Like the animals and plants around us, we are tuned to the cycles of our planet. Time cycles, encoded into our cells, tell us when to sleep and wake, work and play. When we ignore them, we put both our health and our happiness at risk. The development of chronobiology represents a new era in our understanding of the universe. Like the discovery of the microscope, chronobiology is revolutionizing how we view ourselves and our world on every level. Inner Time.
Author: Till Roenneberg Publisher: Harvard University Press ISBN: 0674069692 Category : Science Languages : en Pages : 313
Book Description
Winner of a British Medical Association Book Award A Brain Pickings Best Science Book of the Year Early birds and night owls are born, not made. Sleep patterns may be the most obvious manifestation of the highly individualized biological clocks we inherit, but these clocks also regulate bodily functions from digestion to hormone levels to cognition. Living at odds with our internal timepieces, Till Roenneberg shows, can make us chronically sleep deprived and more likely to smoke, gain weight, feel depressed, fall ill, and fail geometry. By understanding and respecting our internal time, we can live better. “Internal Time is a cautionary tale—actually a series of 24 tales, not coincidentally. Roenneberg ranges widely from the inner workings of biological rhythms to their social implications, illuminating each scientific tutorial with an anecdote inspired by clinical research...Written with grace and good humor, Internal Time is a serious work of science incorporating the latest research in chronobiology...[A] compelling volume.” —A. Roger Ekirch, Wall Street Journal “This is a fascinating introduction to an important topic, which will appeal to anyone who wishes to delve deep into the world of chronobiology, or simply wonders why they struggle to get a good night’s sleep.” —Richard Wiseman, New Scientist
Author: J. M. Waterhouse Publisher: Oxford University Press, USA ISBN: 9780198510741 Category : Family & Relationships Languages : en Pages : 212
Book Description
Why am I always tired? Why can't I sleep at night? Why do I suffer from jetlag? We all have a body clock, a biological structure that controls how we feel, our mental and physical performance, and whether we are active or asleep. This is nature's response to our rhythmic environment, dominated by day and night. Though the body clock normally adjusts us to daytime activity andnight time sleep, it can go wrong or be tricked by lifestyle changes. This can result in jetlag, some forms of insomnia and even depression. Keeping in time with your body clock provides clear and accessible advice on how to live with, and not against, your body clock. In a clear and accessible style, it explains how the body clock works, how and why it can work against you, and the measures you can take to optimise your feeling ofhealth and wellbeing. It also explains the role of the body clock in illness, and how an understanding of this can increase your feeling of health. An essential book for anyone who wants to better understand their body and optimise their feeling of health and wellbeing.
Author: Lothar Ursinus Publisher: Simon and Schuster ISBN: 1644110377 Category : Health & Fitness Languages : en Pages : 128
Book Description
A reference guide to understanding the natural rhythm of our organs and learning to support them in a holistic way • Explains the Organ Body Clock from Traditional Chinese Medicine and which organs and meridians are dominant during different hours of the day • Describes exactly what happens inside the body during each organ’s active time and shows what we can do to support the organs with plant medicine, homeopathy, our behavior, and simple daily practices • Explores the mental and emotional states each organ is related to and their connections to the teeth, the other organs, and the Five Elements of TCM All of our organs are energetically interconnected. They each have regular rest and active cycles throughout the day, with different organs becoming dominant at different hours. In Traditional Chinese Medicine, this is known as the Organ Body Clock. In this accessible guide to the body clock in Traditional Chinese Medicine, the author shows how to support the body’s natural rhythms of activity, recognize the body’s signals of imbalance and find their sources, and achieve healing on the physical and energetic levels. He explains how the body clock can provide deep insight into our physical and energetic health. For example, if we always wake up at a certain time at night, we should look up which organ is associated with that time, which will lead us to discover the part of our body that needs special attention and help. The author explores the 12 major organs of the body, describing their active and rest hours, their function inside the body, the mental and emotional states they are related to, and their connections to the teeth, the other organs, and the Five Elements of TCM. The author describes exactly what happens inside the body during each organ’s active time and shows what we can do to support the organs with plant medicine, homeopathy, our behavior, and simple daily practices. By working with the body clock and better understanding our bodies’ rhythms, we more easily trace our ailments and conditions to their source for faster relief, sustainable healing, and energetic balance.
Author: Marta Del Olmo
Author: Marta Del Olmo
Author: Paul Kelley
Author: Leon Kreitzman
Author: Susan Perry
Author: Michael Smolensky
Author: Carol Orlock
Author: Till Roenneberg
Author: Carol Orlock
Author: J. M. Waterhouse
Author: Lothar Ursinus