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Author: Luisa Salaris Publisher: Presses univ. de Louvain ISBN: 9782874631450 Category : Business & Economics Languages : en Pages : 200
Book Description
The scientific debate on longevity and its determinants is lively and involves researchers from different some people live longer than others is not an easy task. Variables that are shown to be significant for longer survival in certain populations are not always relevant to individuals of other populations. Recently, researchers have identified in Sardinia the Blue Zone (BZ), thus denominated due to the significant number of cases of centenarians recorded as well as a low sex ratio value. A village located in this area was selected for the carrying out of a more detailed analysis at individual level and socio-demographic determinants of longevity were examined. A family reconstructed database was created using a multi-source approach. Historical data was therefore used to study today's population, establishing a unique bridge between historical demography and the current level of longevity. The study focused on survival of newborns in the selected village during a period of 50 years – from 1866 to 1915 – and also took into consideration information on related family members. Each individual included in the database was followed from birth to death, as he/she went through marriage and family formation. Complete survival of all newborns was observed until the present. Based on careful review of the existing literature, the empirical model considered factors such as sex differential, the contribution of familial transmission both in terms of genes, biological, and shared environment, and the role played by environment operationalised considering early-life conditions. Concepts were organized into a life-course approach for survival analysis. The analysis of the data enabled to the estimation of mortality trajectories, which in turn confirmed the exceptional longevity of the population understudy and in particular of males. The investigation of differential survival among members of the same community brought to light the relevance of certain familial variables on survival, which are not exclusively genetic. The results achieved open the way to further studies.
Author: Luisa Salaris Publisher: Presses univ. de Louvain ISBN: 9782874631450 Category : Business & Economics Languages : en Pages : 200
Book Description
The scientific debate on longevity and its determinants is lively and involves researchers from different some people live longer than others is not an easy task. Variables that are shown to be significant for longer survival in certain populations are not always relevant to individuals of other populations. Recently, researchers have identified in Sardinia the Blue Zone (BZ), thus denominated due to the significant number of cases of centenarians recorded as well as a low sex ratio value. A village located in this area was selected for the carrying out of a more detailed analysis at individual level and socio-demographic determinants of longevity were examined. A family reconstructed database was created using a multi-source approach. Historical data was therefore used to study today's population, establishing a unique bridge between historical demography and the current level of longevity. The study focused on survival of newborns in the selected village during a period of 50 years – from 1866 to 1915 – and also took into consideration information on related family members. Each individual included in the database was followed from birth to death, as he/she went through marriage and family formation. Complete survival of all newborns was observed until the present. Based on careful review of the existing literature, the empirical model considered factors such as sex differential, the contribution of familial transmission both in terms of genes, biological, and shared environment, and the role played by environment operationalised considering early-life conditions. Concepts were organized into a life-course approach for survival analysis. The analysis of the data enabled to the estimation of mortality trajectories, which in turn confirmed the exceptional longevity of the population understudy and in particular of males. The investigation of differential survival among members of the same community brought to light the relevance of certain familial variables on survival, which are not exclusively genetic. The results achieved open the way to further studies.
Author: Owen O'Donnell Publisher: Emerald Group Publishing ISBN: 1781905541 Category : Business & Economics Languages : en Pages : 532
Book Description
This volume contains methodological and empirical research on the measurement and causes of health inequality from leading experts in health economics and economic inequality. It is essential reading for researchers working on health inequality and provides an immediate reconnaissance of the frontiers for those entering this exciting field.
Author: National Research Council Publisher: National Academies Press ISBN: 0309217105 Category : Social Science Languages : en Pages : 200
Book Description
During the last 25 years, life expectancy at age 50 in the United States has been rising, but at a slower pace than in many other high-income countries, such as Japan and Australia. This difference is particularly notable given that the United States spends more on health care than any other nation. Concerned about this divergence, the National Institute on Aging asked the National Research Council to examine evidence on its possible causes. According to Explaining Divergent Levels of Longevity in High-Income Countries, the nation's history of heavy smoking is a major reason why lifespans in the United States fall short of those in many other high-income nations. Evidence suggests that current obesity levels play a substantial part as well. The book reports that lack of universal access to health care in the U.S. also has increased mortality and reduced life expectancy, though this is a less significant factor for those over age 65 because of Medicare access. For the main causes of death at older ages-cancer and cardiovascular disease-available indicators do not suggest that the U.S. health care system is failing to prevent deaths that would be averted elsewhere. In fact, cancer detection and survival appear to be better in the U.S. than in most other high-income nations, and survival rates following a heart attack also are favorable. Explaining Divergent Levels of Longevity in High-Income Countries identifies many gaps in research. For instance, while lung cancer deaths are a reliable marker of the damage from smoking, no clear-cut marker exists for obesity, physical inactivity, social integration, or other risks considered in this book. Moreover, evaluation of these risk factors is based on observational studies, which-unlike randomized controlled trials-are subject to many biases.
Author: Bernard Jeune Publisher: ISBN: Category : Health & Fitness Languages : en Pages : 180
Book Description
States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.
Author: Giuseppina Rose Publisher: MDPI ISBN: 3039216783 Category : Science Languages : en Pages : 118
Book Description
In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, although a plethora of variants were indicated to be associated with human longevity, only very few were successfully replicated in different populations, probably because of population specificity, missing heritability as well as a complex interaction among genetic factors with lifestyle and cultural factors, which modulate the individual chance of living longer. Thus, many challenges remain to be addressed in the search for the genetic components of human longevity. This Special Issue is aimed to unify the progress in the analysis of the genetic determinants of human longevity, to take stock of the situation and point to future directions of the field. We invite submissions for reviews, research articles, short-communications dealing with genetic association studies in human longevity, including all types of genetic variation, as well as the characterization of longevity-related genes.
Author: Anne Newman Publisher: Springer Science & Business Media ISBN: 9400750617 Category : Medical Languages : en Pages : 611
Book Description
The average age of the world’s population is increasing at an unprecedented rate and this increase is changing the world. This “Silver tsunami” emphasizes the need to provide advanced training in epidemiology and increase the cadre of experts in the study of aging. This book is designed to summarize unique methodological issues relevant to the study of aging, biomarkers of aging and the biology/physiology of aging and in-depth discussions of the etiology and epidemiology of common geriatric syndromes and diseases. Contributing authors in the book represent many disciplines, not only epidemiology and clinical geriatrics, but also demography, health services, research, cardiovascular disease, diabetes, psychiatry, neurology, social services, musculoskeletal diseases and cancer. The aim of the book is to provide a broad multidisciplinary background for any student/researcher interested in aging. The material in the book is organized and comprehensive. It represents the most up-to-date information on the scientific issues in aging research written by academics who specialize in research and training in the broad field of aging. The structure and organization of the book reflects our course series in the Epidemiology of Aging starting with the broad issues of demography and methodology, and then addressing specific health conditions and geriatric conditions common to older persons.
Author: Serena Dato Publisher: ISBN: 9783039216796 Category : Electronic books Languages : en Pages : 1
Book Description
In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes.
Author: Joseph A. Knight M.D. Publisher: Author House ISBN: 1452067228 Category : Health & Fitness Languages : en Pages : 554
Book Description
Two thousand years ago, the average life expectancy from birth to death of a Roman citizen, an individual better off than most people at that time, was about 22 years (wars, infectious diseases, trauma, etc.). This progressively increased to about 47 years in the U.S. and most European countries by 1900. Today, the average life expectancy in the U.S. is 78 years (women about five years more than men). However, unless the obesity pandemic is reversed and lifestyles improved, the average life expectancy will likely decrease significantly. conversely, if our lifestyles improve, the average life expectancy could reach 85 or more years. Growing older does not necessarily mean growing sicker. Thus, "don't just add years to your life, add life to your years" (Hans Selve). Indeed, of the 15 major causes of death in the U.S., 65-70% are lifestyle-related. In this book, the following documented topics that are associated with diseases and mortality are discussed in detail: theories of aging; diseases and mortality associated with obesity, physical inactivity and poor nutrition; psychological stress (anxiety, depression); addiction (alcohol, tobacco, drugs); violence (suicide, homicide); food-borne and infectious diseases (viral, bacterial, parasitic); and various other conditions (air pollution, asbestosis, trace metals).
Author: Luisa Salaris
Author: Luisa Salaris
Author: Owen O'Donnell
Author: Arie Budovsky
Author: National Research Council
Author: Bernard Jeune
Author: Giuseppina Rose
Author: Anne Newman
Author: Luisa Salaris
Author: Serena Dato
Author: Joseph A. Knight M.D.