Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Conquering RAS PDF full book. Access full book title Conquering RAS by Asfar Azmi. Download full books in PDF and EPUB format.
Author: Asfar Azmi Publisher: Academic Press ISBN: 0128035412 Category : Medical Languages : en Pages : 296
Book Description
Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
Author: Asfar Azmi Publisher: Academic Press ISBN: 0128035412 Category : Medical Languages : en Pages : 296
Book Description
Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
Author: Publisher: Academic Press ISBN: 0128127384 Category : Medical Languages : en Pages : 294
Book Description
Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. - Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research - Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms - Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment
Author: Goli Samimi Publisher: Academic Press ISBN: 9780128198407 Category : Science Languages : en Pages : 188
Book Description
Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field
Author: Courtney C. Coile Publisher: University of Chicago Press ISBN: 022661929X Category : Business & Economics Languages : en Pages : 347
Book Description
In developed countries, men’s labor force participation at older ages has increased in recent years, reversing a decades-long pattern of decline. Participation rates for older women have also been rising. What explains these patterns, and the differences in them across countries? The answers to these questions are pivotal as countries face fiscal and retirement security challenges posed by longer life-spans. This eighth phase of the International Social Security project, which compares the social security and retirement experiences of twelve developed countries, documents trends in participation and employment and explores reasons for the rising participation rates of older workers. The chapters use a common template for analysis, which facilitates comparison of results across countries. Using within-country natural experiments and cross-country comparisons, the researchers study the impact of improving health and education, changes in the occupation mix, the retirement incentives of social security programs, and the emergence of women in the workplace, on labor markets. The findings suggest that social security reforms and other factors such as the movement of women into the labor force have played an important role in labor force participation trends.
Author: Christian Reynolds Publisher: Routledge ISBN: 0429870701 Category : Technology & Engineering Languages : en Pages : 557
Book Description
This comprehensive handbook represents a definitive state of the current art and science of food waste from multiple perspectives. The issue of food waste has emerged in recent years as a major global problem. Recent research has enabled greater understanding and measurement of loss and waste throughout food supply chains, shedding light on contributing factors and practical solutions. This book includes perspectives and disciplines ranging from agriculture, food science, industrial ecology, history, economics, consumer behaviour, geography, theology, planning, sociology, and environmental policy among others. The Routledge Handbook of Food Waste addresses new and ongoing debates around systemic causes and solutions, including behaviour change, social innovation, new technologies, spirituality, redistribution, animal feed, and activism. The chapters describe and evaluate country case studies, waste management, treatment, prevention, and reduction approaches, and compares research methodologies for better understanding food wastage. This book is essential reading for the growing number of food waste scholars, practitioners, and policy makers interested in researching, theorising, debating, and solving the multifaceted phenomenon of food waste.
Author: Publisher: Academic Press ISBN: 9780124167490 Category : Science Languages : en Pages : 364
Book Description
This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Author: David A. Wise Publisher: University of Chicago Press ISBN: 022644287X Category : Business & Economics Languages : en Pages : 417
Book Description
In recent years, the retirement age for public pensions has increased across many countries, and additional increases are in progress or under discussion in many more. The seventh stage of an ongoing research project studying the relationship between social security programs and labor force participation, Social Security Programs and Retirement around the World: The Capacity to Work at Older Ages explores people’s capacity to work beyond the current retirement age. It brings together an international team of scholars from twelve countries—Belgium, Canada, Denmark, France, Germany, Italy, Japan, the Netherlands, Spain, Sweden, the United Kingdom, and the United States—to analyze this issue. Contributors find that many—but not all—individuals have substantial capacity to work at older ages. However, they also consider how policymakers might divide gains in life expectancy between years of work and retirement, as well as the main impediments to longer work life. They consider factors that influence the demand for older workers, as well as the evolution of health and disability status, which may affect labor supply from the older population.
Author: Paul Osterman Publisher: MIT Press ISBN: 0262357372 Category : Business & Economics Languages : en Pages : 337
Book Description
Experts discuss improving job quality in low-wage industries including retail, residential construction, hospitals and long-term healthcare, restaurants, manufacturing, and long-haul trucking. Americans work harder and longer than our counterparts in other industrialized nations. Yet prosperity remains elusive to many. Workers in such low-wage industries as retail, restaurants, and home construction live from paycheck to paycheck, juggling multiple jobs with variable schedules, few benefits, and limited prospects for advancement. These bad outcomes are produced by a range of industry-specific factors, including intense competition, outsourcing and subcontracting, failure to enforce employment standards, overt discrimination, outmoded production and management systems, and inadequate worker voice. In this volume, experts look for ways to improve job quality in the low-wage sector. They offer in-depth examinations of specific industries—long-term healthcare, hospitals and outpatient care, retail, residential construction, restaurants, manufacturing, and long-haul trucking—that together account for more than half of all low-wage jobs. The book's sector view allows the contributors to address industry-specific variations that shape operational choices about work. Drawing on deep industry knowledge, they consider important distinctions within and between these industries; the financial, institutional, and structural incentives that shape the choices employers make; and what it would take to make more jobs better jobs. Contributors Eileen Appelbaum, Rosemary Batt, Dale Belman, Julie Brockman, Françoise Carré, Susan Helper, Matt Hinkel, Tashlin Lakhani, JaeEun Lee, Raphael Martins, Russell Ormiston, Paul Osterman, Can Ouyang, Chris Tilly, Steve Viscelli
Author: Food and Agriculture Organization of the United Nations Publisher: Fao ISBN: Category : Business & Economics Languages : en Pages : 172
Book Description
At the World Food Summit in 1996, governments acknowledged the fundamental contribution of women to food security, and agreed to promote women's' full and equal participation in the economy. This documents provides an overview of the roles of women as key actors for sustainable rural development, as food producers and consumers, in the context of global and regional agricultural trends.
Author: Asfar Azmi
Author: Asfar Azmi
Author: 
Author: Goli Samimi
Author: Courtney C. Coile
Author: Christian Reynolds
Author: Jaume Garcia
Author: 
Author: David A. Wise
Author: Paul Osterman
Author: Food and Agriculture Organization of the United Nations