Author: Publisher:
ISBN:
Category :
Languages : en
Pages : 196
Book Description
Screening of Doping Substances in Human Urine with Gas and Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
Author: Mass Spectrometry in Sports Drug Testing
Author: Mario ThevisPublisher: John Wiley & Sons
ISBN: 1118035143
Category : Science
Languages : en
Pages : 294
Book Description
Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.
Urine Testing for Drugs of Abuse
Author: The Application of Liquid Chromatography Coupled to Mass Spectrometry to Drug Screening in Sport
Author: Karl WoodwardCritical Issues in Alcohol and Drugs of Abuse Testing
Author: Amitava DasguptaPublisher: Academic Press
ISBN: 0128156082
Category : Science
Languages : en
Pages : 560
Book Description
Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians
Liquid Chromatography
Author: Salvatore FanaliPublisher: Elsevier
ISBN: 0128093447
Category : Science
Languages : en
Pages : 840
Book Description
Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making
The Simultaneous Detection of Narcotic Analgesics and Non-steroidal Anti-inflammatory Drugs in Human Urine Using High Performance Liquid Chromatography - Tandem Mass Spectrometry
Author: Andre CoetzeePublisher:
ISBN:
Category : Doping in sports
Languages : en
Pages : 190
Book Description
Liquid-solid Extraction, Immunoaffinity Extraction, and High Performance Liquid Chromatography Combined with Tandem Mass Spectrometry Applied to Doping Control and Ultra-trace Analysis
Author: Karen Ann BeanEuropean Drug Report 2016
Author: Mass Spectrometry for the Detection of Endogenous Steroids and Steroid Abuse in (Race) Horses and Human Athletes
Author: Decloedt AnneleenPublisher:
ISBN:
Category : Science
Languages : en
Pages :
Book Description
The higher the pressure to win, the more athletes are inclined to take steps to improve one's performance through questionable means. To minimize this, strict anti-doping and medication rules are being enforced. All human and equine athletes are regularly subjected to doping analysis to prevent abuse of forbidden substances from affecting their performance. Anabolic-androgenic steroids (AASs) have been part of the forbidden substances list for years, because of their muscle building and performance-enhancing capacities and possible side effects. For most of the AAS, zero-tolerance is held. However, some AASs can be endogenous to the athletes, such as for example testosterone in males. These endogenous steroids can render it very difficult to reveal steroid abuse. Specific mass spectrometric (MS) methods, including ultra-high performance liquid chromatography-MS (UHPLC-MS/MS), high resolution mass spectrometry (HRMS) and gas chromatography-combustion-isotope ratio MS (GC-C-IRMS), have been put forward to overcome these analytical difficulties. Currently, high-tech metabolomic methods are being used to build athlete specific biological passports. In the near future, these passports might allow putting a stop to abuse, by staying ahead of the cheats. These are bright prospects, leading towards clean and fair sports competitions worldwide.