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Author: Floris P. J. T. Rutjes Publisher: Thieme ISBN: 3132442151 Category : Science Languages : en Pages : 750
Book Description
This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.
Author: Floris P. J. T. Rutjes Publisher: Thieme ISBN: 3132442151 Category : Science Languages : en Pages : 750
Book Description
This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.
Author: Srinivasan Chandrasekaran Publisher: John Wiley & Sons ISBN: 3527694188 Category : Science Languages : de Pages : 360
Book Description
This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
Author: Joerg Lahann Publisher: John Wiley & Sons ISBN: 9780470748855 Category : Technology & Engineering Languages : en Pages : 432
Book Description
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.
Author: Srinivasan Chandrasekaran Publisher: John Wiley & Sons ISBN: 3527694153 Category : Science Languages : en Pages : 360
Book Description
This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
Author: Gopinathan Anilkumar Publisher: John Wiley & Sons ISBN: 3527347372 Category : Technology & Engineering Languages : en Pages : 504
Book Description
The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products.
Author: Chen Yu Publisher: ISBN: 9781536119039 Category : Biocompatibility Languages : en Pages : 0
Book Description
Click chemistry, which is also referred to as linkage chemistry, dynamic, combinatorial chemistry or quick linking combinatorial chemistry describes the reaction that joins molecular fragments as simply, efficient and versatile as clicking a mouse. The two units with specific click structures can be linked by a click reaction no matter what is attached to the structure, and only the specific click structures can be joined. It emphasises the development of new combinatorial chemistries on the basis of the synthesis of efficient and highly selective carbon-heteroatom bonds (C-X-C), and effectively prepares molecules with high diversity via these simple reactions. It significantly simplified and promoted the development of synthesis chemistry. Click chemistry has become one of the most useful and attractive synthetic strategies in many fields. In this book, the definition of click chemistry is explained, the characteristics and types of click chemistry are introduced, and some specific reaction types are focused on. The progress for using click chemistry for the synthesis and functionalisation of hydrogels, elastomers, surface modifications, membrane preparations, assemble polyaromatic structures, biomedical fields and optical sensing in biological analyses are described in detail. The problems and challenges for using click chemistry in different fields are analysed.
Author: Joerg Lahann Publisher: John Wiley & Sons ISBN: 0470699701 Category : Technology & Engineering Languages : en Pages : 437
Book Description
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.
Author: Ram K. Gupta Publisher: CRC Press ISBN: 1040127320 Category : Technology & Engineering Languages : en Pages : 295
Book Description
Click chemistry involves highly efficient, reliable, and stereoselective reactions that can synthesize new materials cost-effectively. The first volume entitled “Click Chemistry: Fundamentals and Synthesis” covers the fundamentals, mechanisms, kinetics, and various approaches to synthesizing new materials making it suitable for synthetic chemists and researchers working in nanoscience and technology. The main objective of this book is to provide information about current, state-of-the-art development in click chemistry as well as challenges. Experts from around the world have contributed towards this book, making this a suitable textbook for students and providing new guidelines to researchers and industries working in these areas.
Author: E. Fernández Publisher: Thieme ISBN: 3132429732 Category : Science Languages : en Pages : 582
Book Description
The widespread use of organoboron compounds justifies the efforts devoted to their synthesis, as well as toward developing an understanding of their reactivity. The nature of the mono- or diboron species is of paramount importance in determining the reversible covalent binding properties of the boron atom with both nucleophiles and electrophiles. By wedding the rich chemical potential of organoboron compounds to the ubiquity of organic scaffolds, advanced borylation reactions have the potential to open unprecedented synthetic alternatives, and new knowledge in the field should encourage chemists to use organoboron compounds. In this volume, the main objective is to provide a collection of the most useful, practical, and reliable methods, reported mainly within the last decade, for boron activation and boron reactivity. The volume covers the main concepts of organoboron compounds and includes experimental procedures, enabling newcomers to the field the instant and reliable application of the new tools in synthesis. Rather than aiming for a comprehensive coverage, the most advanced solutions for challenging transformations are introduced. To this end, a team of pioneers and leaders in the field have been assembled who discuss both the practical and conceptual aspects of this rapidly growing field.
Author: Janez Košmrlj Publisher: Springer ISBN: 3642294294 Category : Science Languages : en Pages : 245
Book Description
B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles.
Author: Floris P. J. T. Rutjes
Author: Floris P. J. T. Rutjes
Author: Srinivasan Chandrasekaran
Author: Joerg Lahann
Author: Srinivasan Chandrasekaran
Author: Gopinathan Anilkumar
Author: Chen Yu
Author: Joerg Lahann
Author: Ram K. Gupta
Author: E. Fernández
Author: Janez Košmrlj