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Author: Manuel A. Garrido-Ramos Publisher: Karger Medical and Scientific Publishers ISBN: 3318021490 Category : Medical Languages : en Pages : 239
Book Description
The experimental data that have been generated using new molecular techniques associated with the completion of genome projects have changed our perception of the structural features, functional implications and evolutionary dynamics of repetitive DNA sequences. This volume of Genome Dynamics provides a valuable update on recent developments in research into multigene families, centromeres, telomeres, microsatellite DNA, satellite DNA, and transposable elements. Each chapter presents a review by distinguished experts and analyzes repetitive DNA diversity and abundance, as well as the impact on genome structure, function and evolution. This publication is targeted at scientists and scholars at every level, from students to faculty members, and, indeed, anyone involved or interested in genetics, molecular evolution, molecular biology as well as genomics will find it a valuable source of up-to-date information.
Author: Manuel A. Garrido-Ramos Publisher: Karger Medical and Scientific Publishers ISBN: 3318021490 Category : Medical Languages : en Pages : 239
Book Description
The experimental data that have been generated using new molecular techniques associated with the completion of genome projects have changed our perception of the structural features, functional implications and evolutionary dynamics of repetitive DNA sequences. This volume of Genome Dynamics provides a valuable update on recent developments in research into multigene families, centromeres, telomeres, microsatellite DNA, satellite DNA, and transposable elements. Each chapter presents a review by distinguished experts and analyzes repetitive DNA diversity and abundance, as well as the impact on genome structure, function and evolution. This publication is targeted at scientists and scholars at every level, from students to faculty members, and, indeed, anyone involved or interested in genetics, molecular evolution, molecular biology as well as genomics will find it a valuable source of up-to-date information.
Author: Ðurðica Ugarković Publisher: Springer Nature ISBN: 3030748898 Category : Science Languages : en Pages : 234
Book Description
This book gives a comprehensive overview of the unique roles that non-coding repetitive elements such as satellite DNAs play in different physiological and evolutionary processes. It presents the gene-regulatory aspect of satellite DNAs in different model systems including mammals, insects and plants. In addition, evolutionary aspects of activation of satellite DNAs in terms of transcription and proliferation are highlighted, revealing the role of satellite DNAs in the process of adaptation to changing environment and in the speciation process. Finally, the book discusses satellite DNA activation during pathological transformation and the mechanisms by which they affect disease progression. Namely, some satellite DNAs promote the oncogenic processes by affecting genome epigenetic regulation as well as genome integrity. Readers get a full overview of the latest research on satellite DNA.
Author: Andrew G. Clark Publisher: MDPI ISBN: 3039283669 Category : Science Languages : en Pages : 206
Book Description
Repetitive DNA is ubiquitous in eukaryotic genomes, and, in many species, comprises the bulk of the genome. Repeats include transposable elements that can self-mobilize and disperse around the genome, and tandemly-repeated satellite DNAs that increase in copy number due to replication slippage and unequal crossing over. Despite their abundance, repetitive DNA is often ignored in genomic studies due to technical challenges in their identification, assembly, and quantification. New technologies and methods are now providing the unprecedented power to analyze repetitive DNAs across diverse taxa. Repetitive DNA is of particular interest because it can represent distinct modes of genome evolution. Some repetitive DNA forms essential genome structures, such as telomeres and centromeres, which are required for proper chromosome maintenance and segregation, whereas others form piRNA clusters that regulate transposable elements; thus, these elements are expected to evolve under purifying selection. In contrast, other repeats evolve selfishly and produce genetic conflicts with their host species that drive adaptive evolution of host defense systems. However, the majority of repeats likely accumulate in eukaryotes in the absence of selection due to mechanisms of transposition and unequal crossing over. Even these neutral repeats may indirectly influence genome evolution as they reach high abundance. In this Special Issue, the contributing authors explore these questions from a range of perspectives.
Author: Thengiz Beridze Publisher: Springer Science & Business Media ISBN: 3642707718 Category : Science Languages : en Pages : 160
Book Description
The organization of genomes in higher organisms has been studied extensively in recent years. With current achievements in gene engineering, it seems quite realistic that they will be specifically modified in the nearest future to produce new, economi cally valuable forms of animals and plants. The success of these experiments will depend greatly on the level of our knowledge of the structural features of plant and animal DNAs. Comparative studies of DNA from different organisms began with discovery of its genetic significance in the late 1950's. A few years later it was found that nuclear DNA, the main storage of genetic information,~an consist of several fractions differ ing in some physical and chemical properties. Along with the "major" DNA, bearing the main load during the genotype functioning, the so-called satellite DNAs were discovered. T. G. Beridze, the author of this book, is one of the pioneers in the study of these extraordinary DNAs. The results of his experiments with plant satellite DNAs have essentially influenced the formation of our current ideas on their structure and prop erties.
Author: Godfrey M. Hewitt Publisher: Springer Science & Business Media ISBN: 3642839622 Category : Science Languages : en Pages : 404
Book Description
Taxonomy is fundamental to understanding the variety of life forms, and exciting expansions in molecular biology are re- volutionising the obtained data. This volume reviews the ma- jor molecular biological techniques that are applied in ta- xonomy. The chapters are arranged in three main sections:1) Overviews of important topics in molecular taxonomy; 2) Case studies of the successful application of molecular methods to taxonomic and evolutionary questions; 3) Protocols for a range of generally applicable methods. The described techni- ques include DNA-DNA hybridization, DNA fingerprinting, RFLP analysis, and PCR sequencing.
Author: Tengiz Beridze Publisher: Springer ISBN: 9783642707728 Category : Science Languages : en Pages : 149
Book Description
The organization of genomes in higher organisms has been studied extensively in recent years. With current achievements in gene engineering, it seems quite realistic that they will be specifically modified in the nearest future to produce new, economi cally valuable forms of animals and plants. The success of these experiments will depend greatly on the level of our knowledge of the structural features of plant and animal DNAs. Comparative studies of DNA from different organisms began with discovery of its genetic significance in the late 1950's. A few years later it was found that nuclear DNA, the main storage of genetic information,~an consist of several fractions differ ing in some physical and chemical properties. Along with the "major" DNA, bearing the main load during the genotype functioning, the so-called satellite DNAs were discovered. T. G. Beridze, the author of this book, is one of the pioneers in the study of these extraordinary DNAs. The results of his experiments with plant satellite DNAs have essentially influenced the formation of our current ideas on their structure and prop erties.
Author: Ram Sagar Verma Publisher: Cambridge University Press ISBN: 9780521334808 Category : Science Languages : en Pages : 324
Book Description
'The material included in Heterochromatin is impressively comprehensive and provides timely, authoritative information that would otherwise be difficult to obtain.' BioScience
Author: Publisher: Academic Press ISBN: 0128178205 Category : Medical Languages : en Pages : 290
Book Description
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery
Author: Manuel A. Garrido-Ramos
Author: Manuel A. Garrido-Ramos
Author: Ðurðica Ugarković
Author: Andrew G. Clark
Author: Thengiz Beridze
Author: Godfrey M. Hewitt
Author: Eva Hörandl
Author: Tengiz Beridze
Author: V.M. Dirsh
Author: Ram Sagar Verma
Author: